Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5298-5307

  Pérez Areales, F Javier ^a   Di Pietro, Ornella ^a   Espargaró, Alba ^a   Vallverdú Queralt, Anna ^a,b   Galdeano, Carles ^a   Ragusa, Ilaria M ^a   Viayna, Elisabet ^a   Guillou, Catherine ^c   Clos, M Victòria ^d   Pérez, Belén ^d   Sabaté, Raimon ^a   Lamuela Raventós, Rosa M ^a,b   Luque, F Javier ^a   Muñoz Torrero, Diego ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^d INSTITUT DE NEUROCIÈNCIES   (Spain)

Author keywords

A aggregation inhibitors; Dual binding site AChE inhibitors; Multitarget compounds; Phenolic antioxidants; Tau aggregation inhibitors

Indexed keywords

1 [4 [[(3 CHLORO 6,7,10,11 TETRAHYDRO 9 METHYL 7,11 METHANOCYCLOOCTA[B]QUINOLIN 12 YL)AMINO]METHYL]PHENYL] 5 (4 HYDROXY 3 METHOXYPHENYL)PENT 1 EN 3 ONE; 1 [4 [[(3 CHLORO 6,7,10,11 TETRAHYDRO 9 METHYL 7,11 METHANOCYCLOOCTA[B]QUINOLIN 12 YL)AMINO]METHYL]PHENYL] 5 [3 (DIMETHYLAMINO)METHYL 4 HYDROXY 5 METHOXYPHENYL]PENT 1 EN 3 ONE; 8 [(3 CHLORO 6,7,10,11 TETRAHYDRO 9 METHYL 7,11 METHANOCYCLOOCTA[B]QUINOLIN 12 YL)AMINO] 1 (4 HYDROXY 3 METHOXYPHENYL)OCT 4 EN 3 ONE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CIMETIDINE; CLONIDINE; CORTICOSTERONE; DESIPRAMINE; GALLIC ACID; HUPRINE Y; HYDROCORTISONE; IMIPRAMINE; LOMEFLOXACIN; NORFLOXACIN; OFLOXACIN; PIROXICAM; PROGESTERONE; PROMAZINE; SHOGAOL; SHOGAOL HUPRINE HYBRID; TAU PROTEIN; TESTOSTERONE; UNCLASSIFIED DRUG; VERAPAMIL;

ABTS RADICAL SCAVENGING ASSAY; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; ASSAY; BACTERIAL CELL; BLOOD BRAIN BARRIER; CELL INCLUSION; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; FOLIN CIOCALTEU ASSAY; IC50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; OXIDATIVE STRESS; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PROTEIN AGGREGATION;

EID: 84907532602     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.053     Document Type: Article

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