Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 623-630

  Asadipour, Ali ^a   Alipour, Masoumeh ^b   Jafari, Mona ^b   Khoobi, Mehdi ^b   Emami, Saeed ^c   Nadri, Hamid ^d   Sakhteman, Amirhossein ^d   Moradi, Alireza ^d   Sheibani, Vahid ^a   Homayouni Moghadam, Farshad ^d   Shafiee, Abbas ^b   Foroumadi, Alireza ^a,b  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Coumarin; Docking; Keywords; Kinetic study; N Benzylpiperidine

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; DONEPEZIL; N(1 BENZYLPIPERIDIN 4 YL) 6 BROMO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(1 BENZYLPIPERIDIN 4 YL) 6 NITRO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(1 BENZYLPIPERIDIN 4 YL) 7 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(1 BENZYLPIPERIDIN 4 YL) 8 METHOXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N(BENZYLPIPERIDIN 4 YL) 2 OXO CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 6 BROMO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 6 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 6 NITRO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 7 HYDROXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 7 METHOXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 8 METHOXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; NERVE CELL; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; ALZHEIMER'S DISEASE; BUTYRYLCHOLINESTERASE; COUMARIN; DOCKING; KINETIC STUDY; N-BENZYLPIPERIDINE;

ACETYLCHOLINESTERASE; AMIDES; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORUS; HORSES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887060922     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.024     Document Type: Article

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