Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain

Neurobiology of Disease

Volumn 9, Issue 1, 2002, Pages 88-93

  Mesulam, Marsel ^a   Guillozet, Angela ^a   Shaw, Pamela ^a   Quinn, Bruce ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Acetylcholinesterase; Aging; Cholinergic; Dementia; Neuroglia

Indexed keywords

ACETYLCHOLINE; CHOLINESTERASE; GLUTAMINE;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CASE REPORT; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLIA; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; NEOCORTEX; NEUROPATHOLOGY; PRIORITY JOURNAL;

EID: 0036183539     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2001.0462     Document Type: Article

References (22)

1. The cholinergic deficit coincides with A/3 deposition at the earliest histopathologic stages of Alzheimer disease
2. Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue
3. Compartmentation of brain glutamate metabolism in neurons and glia
4. Cholinergic systems in Alzheimer's disease
5. Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study
6. Cholinesterase inhibitors: From the Calabar bean to Alzheimer therapy
7. Acetylcholinesterase fiber staining in the human hippocampus and parahippocampal gyrus
8. Conversion of acetylcholinesterase to butyrylcholinesterase: Modeling and mutagenesis
9. A "direct coloring" thiocholine method for cholinesterases
10. A histochemical method for localizing cholinesterase activity
11. The systems-level organization of cholinergic innervation in the cerebral cortex and its alterations in Alzheimer's disease
12. Neuroanatomy of cholinesterases in the normal human brain and in Alzheimer's disease
13. Acetylcholinesterase-rich neurons of the human cerebral cortex: Cytoarchitectonic and ontogenetic patterns of distribution
14. Overlap between acetylcholinesterase-rich and choline acetyltransferase-positive (cholinergic) axons in human cerebral cortex
15. Anatomy of cholinesterase inhibition in Alzheimer's disease: Effect of physostigmine and tetrahydroaminoacridine on plaques and tangles
16. Preservation of cholinergic systems in AChE knockouts and the role of BChE in acetylcholme hydrolysis
17. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
18. Degradation of acetylcholine in human airways: Role of butyrylcholinesterase
19. Acetylcholinesterase: Structure and use as a model for specific cation-protein interactions
20. Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability
21. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase