Evaluation of anxiolytic-like, anticonvulsant, antidepressant-like and antinociceptive properties of new 2-substituted 4-hydroxybutanamides with affinity for GABA transporters in mice

Pharmacology Biochemistry and Behavior

Volumn 110, Issue , 2013, Pages 145-153

  Sałat, Kinga ^a   Kulig, Katarzyna ^a   Gajda, Justyna ^a   Wieckowski, Krzysztof ^a   Filipek, Barbara ^a   Malawska, Barbara ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

2 Substituted 4 hydroxybutanamides; Anxiety; Mice; Motor impairments; Pain; Plasma membrane GABA transporters

Indexed keywords

1 (2 CHLOROMETHYL 1 PYRROLIDINYL) 4 (2 OXO 1 PYRROLIDINYL) 2 BUTYNE; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID CARRIER 1; 4 AMINOBUTYRIC ACID CARRIER 2; 4 AMINOBUTYRIC ACID CARRIER 3; ACETIC ACID; ALCOHOL; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTINOCICEPTIVE AGENT; ANXIOLYTIC AGENT; BM 131; FORMALDEHYDE; INDOMETACIN; TIAGABINE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTIDEPRESSANT ACTIVITY; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CHIMNEY; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FORCED SWIMMING TEST; IMMOBILITY; IN VIVO STUDY; LATENT PERIOD; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PAIN; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY; WRITHING TEST;

ANIMALIA; MUS;

2-SUBSTITUTED 4-HYDROXYBUTANAMIDES; ANXIETY; ECT; ELECTROCONVULSIVE THRESHOLD; GABA; GAMMA AMINOBUTYRIC ACID; GATS; MAXIMAL ELECTROSHOCK SEIZURES; MC; MES; METHYLCELLULOSE; MICE; MOTOR IMPAIRMENTS; PAIN; PLASMA MEMBRANE GABA TRANSPORTERS; ROTATIONS PER MINUTE; RPM;

AMIDES; ANALGESICS; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; DRUG EVALUATION, PRECLINICAL; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HYDROXYBUTYRATES; LOCOMOTION; MALE; MICE;

EID: 84886878597     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.06.013     Document Type: Article

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