1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol- 2-one: A selective high-affinity antagonist for the human dopamine D4 receptor with excellent selectivity over ion channels

Journal of Medicinal Chemistry

Volumn 42, Issue 14, 1999, Pages 2706-2715

  Carling, Robert W ^a   Moore, Kevin W ^a   Moyes, Christopher R ^a   Jones, Elizabeth A ^a   Bonner, Katrine ^a   Emms, Frances ^a   Marwood, Rosemary ^a   Patel, Shil ^a   Patel, Smita ^a   Fletcher, Alan E ^a   Beer, Margaret ^a   Sohal, Bindi ^a   Pike, Andrew ^a   Leeson, Paul D ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 CHLOROBENZYLPIPERIDIN 4 YL) 5 METHYL 4 PHENYL 1,3 DIHYDROIMIDAZOL 2 ONE; 1 (3 CYANOBENZYLPIPERIDIN 4 YL) 5 METHYL 4 PHENYL 1,3 DIHYDROIMIDAZOL 2 ONE; 1 (3 METHOXYBENZYLPIPERIDIN 4 YL) 5 METHYL 4 PHENYL 1,3 DIHYDROIMIDAZOL 2 ONE; 1 (BENZYLPIPERIDIN 4 YL) 5 METHYL 4 PHENYL 1,3 DIHYDROIMIDAZOL 2 ONE; BATRACHOTOXIN; DILTIAZEM; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; ION CHANNEL; SPIPERONE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; SCHIZOPHRENIA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; CHO CELLS; CRICETINAE; DOPAMINE ANTAGONISTS; HUMANS; IMIDAZOLES; ION CHANNELS; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033566220     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991029k     Document Type: Article

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