-
1
-
-
84921499016
-
Original 2-(3-alkoxy-1 H -pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)
-
Munier-Lehmann, H.; Lucas-Hourani, M.; Guillou, S.; Helynck, O.; Zanghi, G.; Noel, A.; Tangy, F.; Vidalain, P. O.; Janin, Y. L. Original 2-(3-alkoxy-1 H -pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH) J. Med. Chem. 2015, 58, 860-877
-
(2015)
J. Med. Chem.
, vol.58
, pp. 860-877
-
-
Munier-Lehmann, H.1
Lucas-Hourani, M.2
Guillou, S.3
Helynck, O.4
Zanghi, G.5
Noel, A.6
Tangy, F.7
Vidalain, P.O.8
Janin, Y.L.9
-
2
-
-
84870056690
-
Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles
-
Ermolenko, M. S.; Guillou, S.; Janin, Y. L. Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles Tetrahedron 2013, 69, 257-263
-
(2013)
Tetrahedron
, vol.69
, pp. 257-263
-
-
Ermolenko, M.S.1
Guillou, S.2
Janin, Y.L.3
-
3
-
-
84857043767
-
Few unexpected results from a Suzuki-Miyaura reaction
-
Salanouve, E.; Retailleau, P.; Janin, Y. L. Few unexpected results from a Suzuki-Miyaura reaction Tetrahedron 2012, 68, 2135-2140
-
(2012)
Tetrahedron
, vol.68
, pp. 2135-2140
-
-
Salanouve, E.1
Retailleau, P.2
Janin, Y.L.3
-
4
-
-
84858700639
-
3-Methoxypyrazoles from 1,1-dimethoxyethene, few original results
-
Salanouve, E.; Guillou, S.; Bizouarne, M.; Bonhomme, F. J.; Janin, Y. L. 3-Methoxypyrazoles from 1,1-dimethoxyethene, few original results Tetrahedron 2012, 68, 3165-3171
-
(2012)
Tetrahedron
, vol.68
, pp. 3165-3171
-
-
Salanouve, E.1
Guillou, S.2
Bizouarne, M.3
Bonhomme, F.J.4
Janin, Y.L.5
-
5
-
-
80053277975
-
Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks
-
Guillou, S.; Bonhomme, F. J.; Ermolenko, M. S.; Janin, Y. L. Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks Tetrahedron 2011, 67, 8451-8457
-
(2011)
Tetrahedron
, vol.67
, pp. 8451-8457
-
-
Guillou, S.1
Bonhomme, F.J.2
Ermolenko, M.S.3
Janin, Y.L.4
-
6
-
-
77950812005
-
5-Iodo-3-ethoxypyrazoles, an entry point to new chemical entities
-
Guillou, S.; Janin, Y. L. 5-Iodo-3-ethoxypyrazoles, an entry point to new chemical entities Chem-Eur. J. 2010, 16, 4669-4677
-
(2010)
Chem.-Eur. J.
, vol.16
, pp. 4669-4677
-
-
Guillou, S.1
Janin, Y.L.2
-
7
-
-
77649239355
-
N-Arylation of 3-alkoxypyrazoles, the case of the pyridines
-
Guillou, S.; Bonhomme, F. J.; Chahine, D.; Nesme, O.; Janin, Y. L. N-Arylation of 3-alkoxypyrazoles, the case of the pyridines Tetrahedron 2010, 66, 2654-2663
-
(2010)
Tetrahedron
, vol.66
, pp. 2654-2663
-
-
Guillou, S.1
Bonhomme, F.J.2
Chahine, D.3
Nesme, O.4
Janin, Y.L.5
-
8
-
-
62549095878
-
Carbon-4 arylation of 3-alkoxypyrazoles
-
Guillou, S.; Nesme, O.; Ermolenko, M. S.; Janin, Y. L. Carbon-4 arylation of 3-alkoxypyrazoles Tetrahedron 2009, 65, 3529-3535
-
(2009)
Tetrahedron
, vol.65
, pp. 3529-3535
-
-
Guillou, S.1
Nesme, O.2
Ermolenko, M.S.3
Janin, Y.L.4
-
9
-
-
60649111305
-
Nitrogen's reactivity of various 3-alkoxypyrazoles
-
Guillou, S.; Bonhomme, F. J.; Janin, Y. L. Nitrogen's reactivity of various 3-alkoxypyrazoles Tetrahedron 2009, 65, 2660-2668
-
(2009)
Tetrahedron
, vol.65
, pp. 2660-2668
-
-
Guillou, S.1
Bonhomme, F.J.2
Janin, Y.L.3
-
10
-
-
56249118348
-
An improved preparation of 3-alkoxypyrazoles
-
Guillou, S.; Bonhomme, F. J.; Janin, Y. L. An improved preparation of 3-alkoxypyrazoles Synthesis 2008, 3504-3508
-
(2008)
Synthesis
, pp. 3504-3508
-
-
Guillou, S.1
Bonhomme, F.J.2
Janin, Y.L.3
-
11
-
-
84961291827
-
A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles
-
Coutant, E. P.; Janin, Y. L. A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles Synthesis 2015, 47, 511-516
-
(2015)
Synthesis
, vol.47
, pp. 511-516
-
-
Coutant, E.P.1
Janin, Y.L.2
-
12
-
-
84922661326
-
High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses
-
Lucas-Hourani, M.; Munier-Lehmann, H.; Helynck, O.; Komarova, A.; Despres, P.; Tangy, F.; Vidalain, P. O. High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses J. Vis. Exp. 2014, 87, e51222
-
(2014)
J. Vis. Exp.
, vol.87
, pp. 51222
-
-
Lucas-Hourani, M.1
Munier-Lehmann, H.2
Helynck, O.3
Komarova, A.4
Despres, P.5
Tangy, F.6
Vidalain, P.O.7
-
13
-
-
77956123412
-
Characterization of dengue virus resistance to brequinar in cell culture
-
Qing, M.; Zou, G.; Wang, Q.-Y.; Xu, H. Y.; Dong, H.; Yuan, Z.; Shi, P.-Y. Characterization of dengue virus resistance to brequinar in cell culture Antimicrob. Agents Chemother. 2010, 54, 3686-3695
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3686-3695
-
-
Qing, M.1
Zou, G.2
Wang, Q.-Y.3
Xu, H.Y.4
Dong, H.5
Yuan, Z.6
Shi, P.-Y.7
-
14
-
-
79955032440
-
Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis
-
Hoffmann, H.-H.; Kunz, A.; Simon, V. A.; Palese, P.; Shaw, M. L. Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 5777-5782
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 5777-5782
-
-
Hoffmann, H.-H.1
Kunz, A.2
Simon, V.A.3
Palese, P.4
Shaw, M.L.5
-
15
-
-
79955559702
-
Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)
-
Bonavia, A.; Franti, M.; Keaney, E. P.; Kuhen, K.; Seepersaud, M.; Radetica, B.; Shao, J.; Honda, A.; Dewhurst, J.; Balabanis, K.; Monroe, J.; Wolff, K.; Osborne, C.; Lanieri, L.; Hoffmaster, K.; Amin, A.; Markovits, J.; Broome, M.; Skuba, E.; Cornella-Taracido, I.; Joberty, G.; Bouwmeester, T.; Hamann, L.; Tallarico, J. A.; Tommasi, R.; Compton, T.; Bushell, S. M. Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV) Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 6739-6744
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 6739-6744
-
-
Bonavia, A.1
Franti, M.2
Keaney, E.P.3
Kuhen, K.4
Seepersaud, M.5
Radetica, B.6
Shao, J.7
Honda, A.8
Dewhurst, J.9
Balabanis, K.10
Monroe, J.11
Wolff, K.12
Osborne, C.13
Lanieri, L.14
Hoffmaster, K.15
Amin, A.16
Markovits, J.17
Broome, M.18
Skuba, E.19
Cornella-Taracido, I.20
Joberty, G.21
Bouwmeester, T.22
Hamann, L.23
Tallarico, J.A.24
Tommasi, R.25
Compton, T.26
Bushell, S.M.27
more..
-
16
-
-
80051822664
-
Inhibition of dengue virus through suppression of host pyrimidine biosynthesis
-
Wang, Q.-Y.; Bushell, S.; Qing, M.; Xu, H. A.; Bonavia, A.; Nunes, S.; Zhou, J.; Poh, M. K.; Florez de Sessions, P.; Niyomrattanakit, P.; Dong, H.; Hoffmaster, K.; Goh, A.; Nilar, S.; Schul, W.; Jones, S.; Kramer, L.; Compton, T.; Shi, P.-Y. Inhibition of dengue virus through suppression of host pyrimidine biosynthesis J. Virol. 2011, 6548-6556
-
(2011)
J. Virol.
, pp. 6548-6556
-
-
Wang, Q.-Y.1
Bushell, S.2
Qing, M.3
Xu, H.A.4
Bonavia, A.5
Nunes, S.6
Zhou, J.7
Poh, M.K.8
Florez De Sessions, P.9
Niyomrattanakit, P.10
Dong, H.11
Hoffmaster, K.12
Goh, A.13
Nilar, S.14
Schul, W.15
Jones, S.16
Kramer, L.17
Compton, T.18
Shi, P.-Y.19
-
17
-
-
84887297004
-
Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity
-
Lucas-Hourani, M.; Dauzonne, D.; Jorda, P.; Cousin, G.; Lupan, A.; Helynck, O.; Caignard, G.; Janvier, G.; André-Leroux, G.; Khiar, S.; Escriou, N.; Desprès, P.; Jacob, Y.; Munier-Lehmann, H.; Tangy, F.; Vidalain, P. O. Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity PLOS Pathog. 2013, 9, e1003678
-
(2013)
PLOS Pathog.
, vol.9
, pp. 1003678
-
-
Lucas-Hourani, M.1
Dauzonne, D.2
Jorda, P.3
Cousin, G.4
Lupan, A.5
Helynck, O.6
Caignard, G.7
Janvier, G.8
André-Leroux, G.9
Khiar, S.10
Escriou, N.11
Desprès, P.12
Jacob, Y.13
Munier-Lehmann, H.14
Tangy, F.15
Vidalain, P.O.16
-
18
-
-
84887058080
-
Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis
-
Marschall, M.; Niemann, I.; Kosulin, K.; Bootz, A.; Wagner, S.; Dobner, T.; Herz, T.; Kramer, B.; Leban, J.; Vitt, D.; Stamminger, T.; Hutterer, C.; Strobl, S. Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis Antiviral Res. 2013, 100, 640-648
-
(2013)
Antiviral Res.
, vol.100
, pp. 640-648
-
-
Marschall, M.1
Niemann, I.2
Kosulin, K.3
Bootz, A.4
Wagner, S.5
Dobner, T.6
Herz, T.7
Kramer, B.8
Leban, J.9
Vitt, D.10
Stamminger, T.11
Hutterer, C.12
Strobl, S.13
-
19
-
-
84937688863
-
-
Collaborative Drug Discovery: Burlingame, CA, July 14.
-
Navre, M. Why Using pIC50 Instead of IC50 Will Change Your Life; Collaborative Drug Discovery: Burlingame, CA, July 14, 2014; https://www.collaborativedrug.com/buzz/2014/07/14/why-using-pic50-instead-of-ic50-will-change-your-life/.
-
(2014)
Why Using pIC50 Instead of IC50 Will Change Your Life
-
-
Navre, M.1
-
20
-
-
83055163850
-
Proteomic analysis of virus-host interactions in an infectious context using recombinant viruses
-
Komarova, A. V.; Combredet, C.; Meyniel-Schicklin, L.; Chapelle, M.; Caignard, G.; Camadro, J. M.; Lotteau, V.; Vidalain, P. O.; Tangy, F. Proteomic analysis of virus-host interactions in an infectious context using recombinant viruses Mol. Cell Proteomics 2011, 10, M110.007443
-
(2011)
Mol. Cell Proteomics
, vol.10
, pp. 110007443
-
-
Komarova, A.V.1
Combredet, C.2
Meyniel-Schicklin, L.3
Chapelle, M.4
Caignard, G.5
Camadro, J.M.6
Lotteau, V.7
Vidalain, P.O.8
Tangy, F.9
-
21
-
-
1642479421
-
Mild conditions for copper-catalysed N-arylation of pyrazoles
-
Cristau, H. J.; Cellier, P. P.; Spindler, J. F.; Taillefer, M. Mild conditions for copper-catalysed N-arylation of pyrazoles Eur. J. Org. Chem. 2004, 4, 695-709
-
(2004)
Eur. J. Org. Chem.
, vol.4
, pp. 695-709
-
-
Cristau, H.J.1
Cellier, P.P.2
Spindler, J.F.3
Taillefer, M.4
-
22
-
-
33748805474
-
Efficient synthesis of functionalized organozinc compounds by the direct insertion of zinc into organic iodides and bromides
-
Krasovskiy, A.; Malakhov, V.; Gavryushin, A.; Knochel, P. Efficient synthesis of functionalized organozinc compounds by the direct insertion of zinc into organic iodides and bromides Angew. Chem., Int. Ed. 2006, 45, 6040-6044
-
(2006)
Angew. Chem., Int. Ed.
, vol.45
, pp. 6040-6044
-
-
Krasovskiy, A.1
Malakhov, V.2
Gavryushin, A.3
Knochel, P.4
-
23
-
-
34247857460
-
Highly diastereoselective synthesis of homoallylic alcohols bearing adjacent quaternary centers using substituted allylic zinc reagents
-
Ren, H.; Dunet, G.; Mayer, P.; Knochel, P. Highly diastereoselective synthesis of homoallylic alcohols bearing adjacent quaternary centers using substituted allylic zinc reagents J. Am. Chem. Soc. 2007, 129, 5376-5377
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 5376-5377
-
-
Ren, H.1
Dunet, G.2
Mayer, P.3
Knochel, P.4
-
24
-
-
35348943330
-
Directed ortho insertion (DoI): A new approach to functionalized aryl and heteroaryl Zinc reagents
-
Boudet, N.; Sase, S.; Sinha, P.; Liu, C.-Y.; Krasovskiy, A.; Knochel, P. Directed ortho insertion (DoI): a new approach to functionalized aryl and heteroaryl Zinc reagents J. Am. Chem. Soc. 2007, 129, 12358-12359
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 12358-12359
-
-
Boudet, N.1
Sase, S.2
Sinha, P.3
Liu, C.-Y.4
Krasovskiy, A.5
Knochel, P.6
-
25
-
-
67650566611
-
Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides
-
Han, C.; Buchwald, S. L. Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides J. Am. Chem. Soc. 2009, 131, 7532-7533
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 7532-7533
-
-
Han, C.1
Buchwald, S.L.2
-
26
-
-
0037420766
-
Copper promoted C-N and C-O bond cross-coupling with phenyl and pyridylboronates
-
Chan, D. M. T.; Monaco, K. L.; Li, R.; Bonne, D.; Clark, C. G.; Lam, P. Y. S. Copper promoted C-N and C-O bond cross-coupling with phenyl and pyridylboronates Tetrahedron Lett. 2003, 44, 3863-3865
-
(2003)
Tetrahedron Lett.
, vol.44
, pp. 3863-3865
-
-
Chan, D.M.T.1
Monaco, K.L.2
Li, R.3
Bonne, D.4
Clark, C.G.5
Lam, P.Y.S.6
-
27
-
-
84876522392
-
On dihydroorotate dehydrogenases, their inhibitors and uses
-
Munier-Lehmann, H.; Vidalain, P.-O.; Tangy, F.; Janin, Y. L. On dihydroorotate dehydrogenases, their inhibitors and uses J. Med. Chem. 2013, 56, 3148-3167
-
(2013)
J. Med. Chem.
, vol.56
, pp. 3148-3167
-
-
Munier-Lehmann, H.1
Vidalain, P.-O.2
Tangy, F.3
Janin, Y.L.4
-
28
-
-
0029793899
-
Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme
-
Knecht, W.; Bergjohann, U.; Gonski, S.; Kirschbaum, B.; Löffler, M. Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme Eur. J. Biochem. 1996, 240, 292-301
-
(1996)
Eur. J. Biochem.
, vol.240
, pp. 292-301
-
-
Knecht, W.1
Bergjohann, U.2
Gonski, S.3
Kirschbaum, B.4
Löffler, M.5
-
29
-
-
0344653661
-
Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives
-
Knecht, W.; Löffler, M. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives Biochem. Pharmacol. 1998, 56, 1259-1264
-
(1998)
Biochem. Pharmacol.
, vol.56
, pp. 1259-1264
-
-
Knecht, W.1
Löffler, M.2
-
30
-
-
0025980747
-
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection
-
Bartlett, R. A.; Dinitrijevic, M.; Mattar, T.; Aielinski, T.; Germann, T.; Rude, E.; Thoenes, G. H.; Küchle, C. C. A.; Schorlemmer, H.-U.; Bremmer, E.; Finnegan, A.; Schleyerbach, R. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection Agents Actions 1991, 32, 10-21
-
(1991)
Agents Actions
, vol.32
, pp. 10-21
-
-
Bartlett, R.A.1
Dinitrijevic, M.2
Mattar, T.3
Aielinski, T.4
Germann, T.5
Rude, E.6
Thoenes, G.H.7
Küchle, C.C.A.8
Schorlemmer, H.-U.9
Bremmer, E.10
Finnegan, A.11
Schleyerbach, R.12
-
31
-
-
0029052321
-
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
-
Xu, X.; Williams, J. W.; Bremer, E. G.; Finnegan, A.; Chong, A. S. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide J. Biol. Chem. 1995, 270 (21) 12398-12403
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.21
, pp. 12398-12403
-
-
Xu, X.1
Williams, J.W.2
Bremer, E.G.3
Finnegan, A.4
Chong, A.S.5
-
32
-
-
0030014489
-
Two activities of the immunosuppressive metabolite of Leflunomide, a77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation
-
Xu, X.; Williams, J. W.; Haihua, G.; Finnegan, A.; Chong, A. S.-F. Two activities of the immunosuppressive metabolite of Leflunomide, a77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation Biochem. Pharmacol. 1996, 52, 527-534
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 527-534
-
-
Xu, X.1
Williams, J.W.2
Haihua, G.3
Finnegan, A.4
Chong, A.S.-F.5
-
33
-
-
0025157969
-
Phase II trial with Brequinar (DUP-785, NSC 368390) in patients with metastatic colorectal cancer: A study of the early clinical trials group of the EORTC
-
Dodion, P. F.; Wagener, T. H.; Stoter, G.; Drozd, A.; Lev, L. M.; Skovsgaard, T.; Renard, J.; Cavalli, F. Phase II trial with Brequinar (DUP-785, NSC 368390) in patients with metastatic colorectal cancer: a study of the early clinical trials group of the EORTC Ann. Oncol. 1990, 1, 79-80
-
(1990)
Ann. Oncol.
, vol.1
, pp. 79-80
-
-
Dodion, P.F.1
Wagener, T.H.2
Stoter, G.3
Drozd, A.4
Lev, L.M.5
Skovsgaard, T.6
Renard, J.7
Cavalli, F.8
-
34
-
-
0026707791
-
Multicenter phase II trial of brequinar sodium in patients with advanced melanoma
-
Natale, R.; Wheeler, R.; Moore, M.; Dallaire, B.; Lynch, W.; Carlson, R.; Grillo-Lopez, A.; Gyves, J. Multicenter phase II trial of brequinar sodium in patients with advanced melanoma Ann. Oncol. 1992, 3, 659-660
-
(1992)
Ann. Oncol.
, vol.3
, pp. 659-660
-
-
Natale, R.1
Wheeler, R.2
Moore, M.3
Dallaire, B.4
Lynch, W.5
Carlson, R.6
Grillo-Lopez, A.7
Gyves, J.8
-
35
-
-
0027333360
-
Multicenter phase II study of brequinar sodium in patients with advanced breast cancer
-
Cody, R.; Stewart, D.; DeForni, M.; Moore, M.; Dallaire, B.; Azarnia, N.; Gyves, J. Multicenter phase II study of brequinar sodium in patients with advanced breast cancer Am. J. Clin. Oncol. 1993, 16, 526-528
-
(1993)
Am. J. Clin. Oncol.
, vol.16
, pp. 526-528
-
-
Cody, R.1
Stewart, D.2
Deforni, M.3
Moore, M.4
Dallaire, B.5
Azarnia, N.6
Gyves, J.7
-
36
-
-
0027223547
-
Multicenter phase II study of brequinar sodium in patients with advanced gastrointestinal cancer
-
Moore, M.; Maroun, J.; Robert, F.; Natale, R.; Neidhart, J.; Dallaire, B.; Sisk, R.; Gyves, J. Multicenter phase II study of brequinar sodium in patients with advanced gastrointestinal cancer Invest. New Drugs 1993, 11, 61-65
-
(1993)
Invest. New Drugs
, vol.11
, pp. 61-65
-
-
Moore, M.1
Maroun, J.2
Robert, F.3
Natale, R.4
Neidhart, J.5
Dallaire, B.6
Sisk, R.7
Gyves, J.8
-
37
-
-
0027462415
-
Multicenter phase II study of brequinar sodium in patients with advanced lung cancer
-
Maroun, J.; Ruckdeschel, J.; Natale, R.; Morgan, R.; Dallaire, B.; Sisk, R.; Gyves, J. Multicenter phase II study of brequinar sodium in patients with advanced lung cancer Cancer Chemother. Pharmacol. 1993, 32, 64-66
-
(1993)
Cancer Chemother. Pharmacol.
, vol.32
, pp. 64-66
-
-
Maroun, J.1
Ruckdeschel, J.2
Natale, R.3
Morgan, R.4
Dallaire, B.5
Sisk, R.6
Gyves, J.7
-
38
-
-
84867863583
-
Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC
-
Contreras-Sanz, A.; Scott-Ward, T. S.; Gill, H. S.; Jacoby, J. C.; Birch, R. E.; Malone-Lee, J.; Taylor, K. M.; Peppiatt-Wildman, C. M.; Wildman, S. S. Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC Purinergic Signalling 2012, 8, 741-751
-
(2012)
Purinergic Signalling
, vol.8
, pp. 741-751
-
-
Contreras-Sanz, A.1
Scott-Ward, T.S.2
Gill, H.S.3
Jacoby, J.C.4
Birch, R.E.5
Malone-Lee, J.6
Taylor, K.M.7
Peppiatt-Wildman, C.M.8
Wildman, S.S.9
-
39
-
-
84888338846
-
The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro
-
Li, L.; Liu, J.; Delohery, T.; Zhang, D.; Arendt, C.; Jones, C. The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro J. Neuroimmunol. 2013, 265, 82-90
-
(2013)
J. Neuroimmunol.
, vol.265
, pp. 82-90
-
-
Li, L.1
Liu, J.2
Delohery, T.3
Zhang, D.4
Arendt, C.5
Jones, C.6
-
40
-
-
0035821602
-
Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection
-
Papageorgiou, C.; von Matt, A.; Joergensen, J.; Andersen, E.; Wagner, K.; Beerli, C.; Than, T.; Borer, X.; Florineth, A.; Rihs, G.; Schreier, M. H.; Weckbecker, G.; Heusser, C. Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection J. Med. Chem. 2001, 44, 1986-1992
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1986-1992
-
-
Papageorgiou, C.1
Von Matt, A.2
Joergensen, J.3
Andersen, E.4
Wagner, K.5
Beerli, C.6
Than, T.7
Borer, X.8
Florineth, A.9
Rihs, G.10
Schreier, M.H.11
Weckbecker, G.12
Heusser, C.13
-
41
-
-
77956061618
-
An N -(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model
-
Chen, J.; Xia, J.; Axelsson, B.; Fritzon, I.; Ekberg, H.; Törngren, M.; Qi, Z. An N -(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model Transplant Immunol. 2010, 23, 180-184
-
(2010)
Transplant Immunol.
, vol.23
, pp. 180-184
-
-
Chen, J.1
Xia, J.2
Axelsson, B.3
Fritzon, I.4
Ekberg, H.5
Törngren, M.6
Qi, Z.7
-
42
-
-
77953773127
-
Plasmodium dihydroorotate dehydrogenase: A promising target for novel anti-malarial chemotherapy
-
Phillips, M. A.; Rathod, P. K. Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy Infect. Disord. Drug Targets 2010, 10, 226-239
-
(2010)
Infect. Disord. Drug Targets
, vol.10
, pp. 226-239
-
-
Phillips, M.A.1
Rathod, P.K.2
-
43
-
-
80052624721
-
Optimization of potent inhibitors of P. Falciparum dihydroorotate dehydrogenase for the treatment of malaria
-
Skerlj, R. T.; Bastos, C. M.; Booker, M. L.; Kramer, M. L.; Barker, R. H.; Celatka, C. A.; O'Shea, T. G.; Munoz, B.; Sidhu, A. B.; Cortese, J. F.; Wittlin, S.; Papastogiannidis, P.; Angulo-Barturen, I.; Jimenez-Diaz, M. B.; Sybertz, E. Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria ACS Med. Chem. Lett. 2011, 2, 708-713
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 708-713
-
-
Skerlj, R.T.1
Bastos, C.M.2
Booker, M.L.3
Kramer, M.L.4
Barker, R.H.5
Celatka, C.A.6
O'Shea, T.G.7
Munoz, B.8
Sidhu, A.B.9
Cortese, J.F.10
Wittlin, S.11
Papastogiannidis, P.12
Angulo-Barturen, I.13
Jimenez-Diaz, M.B.14
Sybertz, E.15
Skerlj, R.T.16
Bastos, C.M.17
Booker, M.L.18
Kramer, M.L.19
Barker, R.H.20
Celatka, C.A.21
O'Shea, T.G.22
Munoz, B.23
Sidhu, A.B.24
Cortese, J.F.25
Wittlin, S.26
Papastogiannidis, P.27
Angulo-Barturen, I.28
Jimenez-Diaz, M.B.29
Sybertz, E.30
more..
-
44
-
-
79961223551
-
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
-
Coteron, J. M.; Marco, M.; Esquivias, J.; Deng, X.; White, K. L.; White, J.; Koltun, M.; El Mazouni, F.; Kokkonda, S.; Katneni, K.; Bhamidipati, R.; Shackleford, D. M.; Angulo-Barturen, I.; Ferrer, S. B.; Jiménez-Díaz, M. B.; Gamo, F. J.; Goldsmith, E. J.; Charman, W. N.; Bathurst, I.; Floyd, D.; Matthews, D.; Burrows, J. N.; Rathod, P. K.; Charman, S. A.; Phillips, M. A. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential J. Med. Chem. 2011, 54, 5540-5561
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5540-5561
-
-
Coteron, J.M.1
Marco, M.2
Esquivias, J.3
Deng, X.4
White, K.L.5
White, J.6
Koltun, M.7
El Mazouni, F.8
Kokkonda, S.9
Katneni, K.10
Bhamidipati, R.11
Shackleford, D.M.12
Angulo-Barturen, I.13
Ferrer, S.B.14
Jiménez-Díaz, M.B.15
Gamo, F.J.16
Goldsmith, E.J.17
Charman, W.N.18
Bathurst, I.19
Floyd, D.20
Matthews, D.21
Burrows, J.N.22
Rathod, P.K.23
Charman, S.A.24
Phillips, M.A.25
more..
-
45
-
-
84876685433
-
Recent advances in malaria drug discovery
-
Biamonte, M. A.; Wanner, J.; Le Roch, K. G. Recent advances in malaria drug discovery Bioorg. Med. Chem. Lett. 2013, 23, 2829-2843
-
(2013)
Bioorg. Med. Chem. Lett.
, vol.23
, pp. 2829-2843
-
-
Biamonte, M.A.1
Wanner, J.2
Le Roch, K.G.3
-
46
-
-
84903523660
-
In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth
-
Ross, L. S.; Gamo, F. J.; Lafuente-Monasterio, M. J.; Singh, O. M.; Rowland, P.; Wiegand, R. C.; Wirth, D. F. In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth J. Biol. Chem. 2014, 289, 17980-17995
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 17980-17995
-
-
Ross, L.S.1
Gamo, F.J.2
Lafuente-Monasterio, M.J.3
Singh, O.M.4
Rowland, P.5
Wiegand, R.C.6
Wirth, D.F.7
-
47
-
-
65649152331
-
Structure-based design, synthesis; Characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
-
Davies, M.; Heikkila, T.; McConkey, G. A.; Fishwick, C. W.; Parsons, M. R.; Johnson, A. P. Structure-based design, synthesis; characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J. Med. Chem. 2009, 52, 2683-2693
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2683-2693
-
-
Davies, M.1
Heikkila, T.2
McConkey, G.A.3
Fishwick, C.W.4
Parsons, M.R.5
Johnson, A.P.6
-
48
-
-
84865808746
-
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases
-
Bedingfield, P. T. P.; Cowen, D.; Acklam, P.; Cunningham, F.; Parsons, M. R.; McConkey, G. A.; Fishwick, C. W. G.; Johnson, A. P. Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases J. Med. Chem. 2012, 55, 5841-5850
-
(2012)
J. Med. Chem.
, vol.55
, pp. 5841-5850
-
-
Bedingfield, P.T.P.1
Cowen, D.2
Acklam, P.3
Cunningham, F.4
Parsons, M.R.5
McConkey, G.A.6
Fishwick, C.W.G.7
Johnson, A.P.8
-
49
-
-
84903513282
-
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors
-
Deng, X.; Kokkonda, S.; El Mazouni, F.; White, J.; Burrows, J. N.; Kaminsky, W.; Charman, S. A.; Matthews, D.; Rathod, P. K.; Phillips, M. A. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors J. Med. Chem. 2014, 57, 5381-5394
-
(2014)
J. Med. Chem.
, vol.57
, pp. 5381-5394
-
-
Deng, X.1
Kokkonda, S.2
El Mazouni, F.3
White, J.4
Burrows, J.N.5
Kaminsky, W.6
Charman, S.A.7
Matthews, D.8
Rathod, P.K.9
Phillips, M.A.10
-
50
-
-
84922770542
-
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole-derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase
-
Zhu, J.; Han, L.; Diao, Y.; Ren, X.; Xu, M.; Xu, L. X.; Li, S.; Li, Q.; Dong, D.; Huang, J.; Liu, X.; Zhao, Z.; Wang, R.; Zhu, L.; Xu, Y.; Qian, X.; Li, H. Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole-derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase J. Med. Chem. 2015, 58, 1123-1139
-
(2015)
J. Med. Chem.
, vol.58
, pp. 1123-1139
-
-
Zhu, J.1
Han, L.2
Diao, Y.3
Ren, X.4
Xu, M.5
Xu, L.X.6
Li, S.7
Li, Q.8
Dong, D.9
Huang, J.10
Liu, X.11
Zhao, Z.12
Wang, R.13
Zhu, L.14
Xu, Y.15
Qian, X.16
Li, H.17
-
51
-
-
0032804664
-
Mechanism of action for leflunomide in rheumatoid arthritis
-
Fox, R. I.; Herrmann, M. L.; Frangou, C. G.; Wahl, G. M.; Morris, R. E.; Strand, V.; Kirschbaum, B. J. Mechanism of action for leflunomide in rheumatoid arthritis Clin. Immunol. 1999, 93, 198-208
-
(1999)
Clin. Immunol.
, vol.93
, pp. 198-208
-
-
Fox, R.I.1
Herrmann, M.L.2
Frangou, C.G.3
Wahl, G.M.4
Morris, R.E.5
Strand, V.6
Kirschbaum, B.J.7
-
52
-
-
84858336657
-
Leflunomide in dermatology
-
Boyd, A. S. Leflunomide in dermatology J. Am. Acad. Dermatol. 2012, 66, 673-679
-
(2012)
J. Am. Acad. Dermatol.
, vol.66
, pp. 673-679
-
-
Boyd, A.S.1
-
53
-
-
0346256826
-
Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement
-
Leban, J.; Saeb, W.; Garcia, G.; Baumgartner, R.; Kramer, B. Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement Bioorg. Med. Chem. Lett. 2004, 14, 55-58
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 55-58
-
-
Leban, J.1
Saeb, W.2
Garcia, G.3
Baumgartner, R.4
Kramer, B.5
-
54
-
-
25144446841
-
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors
-
Leban, J.; Kralik, M.; Mies, J.; Gassen, M.; Tentschaert, K.; Baumgartner, R. SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors Bioorg. Med. Chem. Lett. 2005, 15, 4854-4857
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 4854-4857
-
-
Leban, J.1
Kralik, M.2
Mies, J.3
Gassen, M.4
Tentschaert, K.5
Baumgartner, R.6
-
55
-
-
27944451743
-
Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors
-
Leban, J.; Kralik, M.; Mies, J.; Baumgartner, R.; Gassen, M.; Tasler, S. Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors Bioorg. Med. Chem. Lett. 2006, 16, 267-270
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 267-270
-
-
Leban, J.1
Kralik, M.2
Mies, J.3
Baumgartner, R.4
Gassen, M.5
Tasler, S.6
-
56
-
-
33144458560
-
Dual binding mode of a novel series of DHODH inhibitors
-
Baumgartner, R.; Walloschek, M.; Kralik, M.; Gotschlich, A.; Tasler, S.; Mies, J.; Leban, J. Dual binding mode of a novel series of DHODH inhibitors J. Med. Chem. 2006, 49, 1239-1247
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1239-1247
-
-
Baumgartner, R.1
Walloschek, M.2
Kralik, M.3
Gotschlich, A.4
Tasler, S.5
Mies, J.6
Leban, J.7
-
57
-
-
77953227262
-
4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice
-
Kulkarni, O. P.; Sayyed, S. G.; Kantner, C.; Ryu, M.; Schnurr, M.; Sárdy, M.; Leban, J.; Jankowsky, R.; Ammendola, A.; Doblhofer, R.; Anders, H. J. 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice Am. J. Pathol. 2010, 176, 2840-2847
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2840-2847
-
-
Kulkarni, O.P.1
Sayyed, S.G.2
Kantner, C.3
Ryu, M.4
Schnurr, M.5
Sárdy, M.6
Leban, J.7
Jankowsky, R.8
Ammendola, A.9
Doblhofer, R.10
Anders, H.J.11
-
58
-
-
84862299279
-
Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation
-
Rusai, K.; Schmaderer, C.; Baumann, M.; Chmielewski, S.; Prókai, A.; Kis, E.; Szabó, A. J.; Leban, J.; Doblhofer, R.; Ammendola, A.; Lutz, J.; Heemann, U. Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation Transplantation 2012, 93, 1101-1107
-
(2012)
Transplantation
, vol.93
, pp. 1101-1107
-
-
Rusai, K.1
Schmaderer, C.2
Baumann, M.3
Chmielewski, S.4
Prókai, A.5
Kis, E.6
Szabó, A.J.7
Leban, J.8
Doblhofer, R.9
Ammendola, A.10
Lutz, J.11
Heemann, U.12
-
60
-
-
77950647749
-
Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N -(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection
-
Fritzson, I.; Svensson, B.; Al-Karadaghi, S.; Walse, B.; Wellmar, U.; Nilsson, U. J.; da Graça Thrige, D.; Jönsson, S. Inhibition of human DHODH by 4-hydroxycoumarins, fenamic acids, and N -(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection ChemMedChem 2010, 5, 608-617
-
(2010)
ChemMedChem
, vol.5
, pp. 608-617
-
-
Fritzson, I.1
Svensson, B.2
Al-Karadaghi, S.3
Walse, B.4
Wellmar, U.5
Nilsson, U.J.6
Da Graça Thrige, D.7
Jönsson, S.8
-
62
-
-
77955418807
-
Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles
-
Lemoine, R. C.; Petersen, A. C.; Setti, L.; Jekle, A.; Heilek, G.; deRosier, A.; Ji, C.; Berry, P.; Rotstein, D. M. Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles Bioorg. Med. Chem. Lett. 2010, 20, 4753-4756
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 4753-4756
-
-
Lemoine, R.C.1
Petersen, A.C.2
Setti, L.3
Jekle, A.4
Heilek, G.5
Derosier, A.6
Ji, C.7
Berry, P.8
Rotstein, D.M.9
-
63
-
-
2142640849
-
Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening
-
Smilkstein, M.; Sriwilaijaroen, N.; Kelly, J. X.; Wilairat, P.; Riscoe, M. Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening Antimicrob. Agents Chemother. 2004, 48, 1803-1806
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 1803-1806
-
-
Smilkstein, M.1
Sriwilaijaroen, N.2
Kelly, J.X.3
Wilairat, P.4
Riscoe, M.5
-
64
-
-
70350385202
-
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
-
Deng, X.; Gujjar, R.; El Mazouni, F.; Kaminsky, W.; Malmquist, N. A.; Goldschmidt, E. J.; Rathod, P. K.; Phillips, M. A. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds J. Biol. Chem. 2009, 284, 26999-27009
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26999-27009
-
-
Deng, X.1
Gujjar, R.2
El Mazouni, F.3
Kaminsky, W.4
Malmquist, N.A.5
Goldschmidt, E.J.6
Rathod, P.K.7
Phillips, M.A.8
-
65
-
-
30444439687
-
-
WO 2005028444.
-
Fink, C. A.; Perez, L. B.; Ramsey, T.; Yusuff, N.; Versace, R. W.; Batt, D. B.; Sabio, M. L.; Kim, S. 1,4-Disubstituted isoquinilone derivatives as Raf-kinase inhibitors useful for the treatment of proliferative diseases. WO 2005028444, 2005.
-
(2005)
1,4-Disubstituted Isoquinilone Derivatives As Raf-kinase Inhibitors Useful for the Treatment of Proliferative Diseases
-
-
Fink, C.A.1
Perez, L.B.2
Ramsey, T.3
Yusuff, N.4
Versace, R.W.5
Batt, D.B.6
Sabio, M.L.7
Kim, S.8
-
66
-
-
84937717892
-
-
WO 2007017114.
-
Orchard, M. G.; Benghezal, M.; Braillard, S.; Burn, C.; Cosson, P.; Deuschel, C.; Lucas, A.; Pacaud, J. P.; Valentino, E. New substituted azathymidine derivatives and their use in the treatment of bacterial infectious diseases. WO 2007017114, 2007.
-
(2007)
New Substituted Azathymidine Derivatives and Their Use in the Treatment of Bacterial Infectious Diseases
-
-
Orchard, M.G.1
Benghezal, M.2
Braillard, S.3
Burn, C.4
Cosson, P.5
Deuschel, C.6
Lucas, A.7
Pacaud, J.P.8
Valentino, E.9
-
67
-
-
2942708137
-
Synthesis of imidazolo[5,4- b ]carbazole-4,10-quinones
-
Desforges, G.; Bossert, C.; Montagne, C.; Joseph, B. Synthesis of imidazolo[5,4- b ]carbazole-4,10-quinones Synlett 2004, 1306-1308
-
(2004)
Synlett
, pp. 1306-1308
-
-
Desforges, G.1
Bossert, C.2
Montagne, C.3
Joseph, B.4
-
68
-
-
1642528362
-
A general and mild Ullmann-type synthesis of diaryl ethers
-
Cristau, H. J.; Cellier, P. P.; Hamada, S.; Spindler, J. F.; Taillefer, M. A general and mild Ullmann-type synthesis of diaryl ethers Org. Lett. 2004, 6, 913-916
-
(2004)
Org. Lett.
, vol.6
, pp. 913-916
-
-
Cristau, H.J.1
Cellier, P.P.2
Hamada, S.3
Spindler, J.F.4
Taillefer, M.5
-
69
-
-
33644924126
-
Convenient titration method for organometallic zinc, magnesium, and lanthanide reagents
-
Krasovskiy, A.; Knochel, P. Convenient titration method for organometallic zinc, magnesium, and lanthanide reagents Synthesis 2006, 890-891
-
(2006)
Synthesis
, pp. 890-891
-
-
Krasovskiy, A.1
Knochel, P.2
|