Original 2-(3-Alkoxy-1 H -pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Journal of Medicinal Chemistry

Volumn 58, Issue 14, 2015, Pages 5579-5598

  Lucas Hourani, Marianne ^a,b   Munier Lehmann, Hélène ^b,c   El Mazouni, Farah ^d   Malmquist, Nicholas A ^a,b,e   Harpon, Jane ^a,b,e   Coutant, Eloi P ^b,c   Guillou, Sandrine ^b,c   Helynck, Olivier ^b,c   Noel, Anne ^b,c   Scherf, Artur ^a,b,e   Phillips, Margaret A ^d   Tangy, Frédéric ^a,b   Vidalain, Pierre Olivier ^a,b   Janin, Yves L ^b,c  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c Unité de Chimie et Biocatalyse Département de Biologie Structurale et Chimie   (France)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 ALKOXY 1H PYRAZOL 1 YL)AZINE DERIVATIVE; 5 CYCLOPROPYL 2 [4 (2,6 DIFLUOROPHENOXY) 3 ISOPROPOXY 5 METHYL 1H PYRAZOL 1 YL] 3 FLUOROPYRIDINE; ANTIVIRUS AGENT; BREQUINAR; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; TERIFLUNOMIDE; UNCLASSIFIED DRUG; DIHYDROOROTATE DEHYDROGENASE; ENZYME INHIBITOR; OXIDOREDUCTASE; PYRAZOLE; PYRAZOLE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INHIBITION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; JURKAT CELL LINE; MEASLES VIRUS; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; IC50; PHYSIOLOGY; SYNTHESIS;

ANTIVIRAL AGENTS; DRUG DESIGN; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MEASLES VIRUS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; PYRAZOLES; VIRUS REPLICATION;

EID: 84937705300     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00606     Document Type: Article

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