Original 2-(3-alkoxy-1 H -pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

Journal of Medicinal Chemistry

Volumn 58, Issue 2, 2015, Pages 860-877

  Munier Lehmann, Hélène ^a,b   Lucas Hourani, Marianne ^a,b   Guillou, Sandrine ^a,b   Helynck, Olivier ^a,b   Zanghi, Gigliola ^a,b   Noel, Anne ^a,b   Tangy, Frédéric ^a,b   Vidalain, Pierre Olivier ^a,b   Janin, Yves L ^a,b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 ALKOXY 1H PYRAZOL 1 YL)PYRIMIDINE DERIVATIVE; 2 (3 ETHOXY 4 (2 FLUOROPHENOXY) 5 METHYL 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (3 ETHOXY 4 IODO 5 METHYL 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (3 ETHOXY 5 METHYL 4 (2 (TRIFLUOROMETHYL)PHENOXY) 1H PYRAZOL 1 TL) 5 ETHYLPYRIMIDINE; 2 (3 ETHOXY 5 METHYL 4 PHENOXY 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (4 (2 BROMOPHENOXY)3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (4 (2 CHLOROPHENOXY)3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (4 BENZYL 3 (2 (BENZYLOXY)ETHOXY) 5 METHYL 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 BROMOPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 CYCLOPROPYLPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 ETHYLPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 METHOXYPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 METHYLPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 PENTYLPYRIMIDINE; 2 (4 BENZYL 3 ETHOXY 5 METHYL 1H PYRAZOL 1 YL) 5 PROPYLPYRIMIDINE; 2 (4 BENZYL 3 ISOPROPOXY 5 METHYL 1H PYRAZOL 1 YL) 5 CYCLOPROPYLPYRIMIDINE; 4 BENZYL 1 (5 CYCLOPROPYLPYRIMIDIN 2 YL) 5 METHYL 1H PYRAZOL 3 OL; 4 BENZYL 1 (5 ETHYLPYRIMIDIN 2 YL) 5 METHYL 1H PYRAZOL 3 OL; 5 CYCLOPROPYL 2 (4 (2 FLUOROBENZYL) 3 ISOPROPOXY 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; 5 ETHYL 2 (3 ISOPROPOXY 4 (2 METHOXYBENZYL) 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; 5 ETHYL 2 (3 ISOPROPOXY 4 (3 METHOXYBENZYL) 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; 5 ETHYL 2 (3 ISOPROPOXY 4 (4 METHOXYBENZYL) 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; 5 ETHYL 2 (4 (2 FLUOROBENZYL) 3 ISOPROPOXY 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; 5 ETHYL 2 (4 (3 FLUOROBENZYL) 3 ISOPROPOXY 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; 5 ETHYL 2 (4 (4 FLUOROBENZYL) 3 ISOPROPOXY 5 METHYL 1H PYRAZOL 1 YL)PYRIMIDINE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; PYRIMIDINE DERIVATIVE; UBIDECARENONE; UBIQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIVIRUS AGENT; DIHYDROOROTATE DEHYDROGENASE; ENZYME INHIBITOR; OXIDOREDUCTASE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; SYNTHESIS;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; HUMANS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84921499016     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501446r     Document Type: Article

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