Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 2, 2006, Pages 267-270

  Leban, Johann ^a   Kralik, Martin ^a   Mies, Jan ^a   Baumgartner, Roland ^a   Gassen, Michael ^a   Tasler, Stefan ^a  

^a 4SC AG   (Germany)

Author keywords

DHODH inhibitors

Indexed keywords

BREQUINAR; CARBOXYLIC ACID DERIVATIVE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; ISOMER; METALLATION; PERIPHERAL BLOOD MONONUCLEAR CELL;

BIPHENYL COMPOUNDS; CARBAMATES; CARBOXYLIC ACIDS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 27944451743     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.011     Document Type: Article

References (8)

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8. 50 values were determined using a fitting function.