Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 1, 2004, Pages 55-58

  Leban, Johann ^a   Saeb, Wael ^a   Garcia, Gabriel ^a   Baumgartner, Roland ^a   Kramer, Bernd ^a  

^a 4SC AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BREQUINAR; DIHYDROFOLATE REDUCTASE INHIBITOR; TERIFLUNOMIDE;

ARTICLE; CRYSTALLIZATION; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR DYNAMICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS;

EID: 0346256826     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.021     Document Type: Article

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15. All compounds were characterized by MS and NMR (300 MHz) and exhibited satisfactory properties. Examples are given for a few compounds.