Inhibition of human dhodh by 4-hydroxycoumarins, fenamic acids, and n-(alkylcarbonyl)anthranilic acids identified by structure-guided fragment selection

ChemMedChem

Volumn 5, Issue 4, 2010, Pages 608-617

  Fritzson, Ingela ^a   Svensson, Bo ^b   Al Karadaghi, Salam ^c   Walse, Björn ^b   Wellmar, Ulf ^a   Nilsson, Ulf J ^c   Da Graça Thrige, Dorthe ^a   Jönsson, Stig ^d  

^a Active Biotech Research AB   (Sweden)

^b SARomics AB   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d MIP Technologies AB   (Sweden)

Author keywords

Dihydroorotate dehydrogenase; Drug discovery; Fragment screening; Inhibitors; Structure activity relationships

Indexed keywords

4 HYDROXY 3 (4 TRIFLUOROMETHYLBENZYL)COUMARIN; 4,5 DIHYDROXY 3 (4 BIPHENYL)COUMARIN; ANTHRANILIC ACID; BENZOIC ACID; BREQUINAR; COUMARIN DERIVATIVE; DICOUMAROL; DIHYDROOROTATE DEHYDROGENASE; FENAMIC ACID DERIVATIVE; REDOXAL; TERIFLUNOMIDE; UBIQUINONE; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

4-HYDROXYCOUMARINS; ANTHRANILIC ACIDS; BINDING SITES; COMPUTER SIMULATION; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950647749     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900454     Document Type: Article

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