Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 12, 2014, Pages 5381-5394

  Deng, Xiaoyi ^a   Kokkonda, Sreekanth ^b   El Mazouni, Farah ^a   White, John ^b   Burrows, Jeremy N ^d   Kaminsky, Werner ^b   Charman, Susan A ^c   Matthews, David ^d   Rathod, Pradipsinh K ^b   Phillips, Margaret A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c MONASH UNIVERSITY   (Australia)

^d Medicines for Malaria Venture   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE INHIBITOR; FLUORINE; TRIAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG SELECTIVITY; ENTROPY; FLUORINATION; HYDROGEN BOND; HYDROPHOBICITY; PLASMODIUM FALCIPARUM; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS;

ANIMALS; ANTIMALARIALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOGS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; PYRIMIDINES; RATS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THIAZOLES;

EID: 84903513282     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500481t     Document Type: Article

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