Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection

Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2001, Pages 1986-1992

  Papageorgiou, C ^a   Von Matt, A ^a   Joergensen, J ^a   Andersen, E ^a   Wagner, K ^a   Beerli, C ^a   Than, T ^a   Borer, X ^a   Florineth, A ^a   Rihs, G ^a   Schreier, M H ^a   Weckbecker, G ^a   Heusser, C ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; N [4 (TRIFLUOROMETHYL)PHENYL]QUINOLINE 8 CARBOXAMIDE; N [5 (TRIFLUOROMETHYL)PYRIDIN 2 YL]QUINOLE 8 CARBOXAMIDE; QUINOLINE 8 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; DRUG CONFORMATION; DRUG EFFICACY; DRUG STRUCTURE; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; MALE; MOUSE; NONHUMAN; STRUCTURE ANALYSIS; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; CRICETINAE; DRUG DESIGN; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; LIPOPOLYSACCHARIDES; MESOCRICETUS; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS;

EID: 0035821602     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010822m     Document Type: Article

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