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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4753-4756

Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles

(9) Lemoine, Rémy C a Petersen, Ann C a Setti, Lina a Jekle, Andreas a Heilek, Gabrielle a Derosier, André a Ji, Changhua a Berry, Pamela a Rotstein, David M a

a ROCHE BIOSCIENCE (United States)

Author keywords

CCR5 antagonists; Pyrazoles

Indexed keywords

CHEMOKINE RECEPTOR CCR5 ANTAGONIST; PYRAZOLE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; LIPOPHILICITY; NONHUMAN; REACTION ANALYSIS; CHEMISTRY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-HIV AGENTS; HUMANS; PYRAZOLES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; CCR5 RECEPTOR ANTAGONISTS;

EID: 77955418807 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.06.135 Document Type: Article

Times cited : (8)

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