-
1
-
-
0030978351
-
β-Catenin is a target for the ubiquitin-proteasome pathway
-
CrossRef Medline
-
Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16:3797-3804. CrossRef Medline
-
(1997)
EMBO J
, vol.16
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
2
-
-
19944413626
-
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS
-
CrossRef Medline
-
Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD (2004) bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306: 2111-2115. CrossRef Medline
-
(2004)
Science
, vol.306
, pp. 2111-2115
-
-
Arnett, H.A.1
Fancy, S.P.2
Alberta, J.A.3
Zhao, C.4
Plant, S.R.5
Kaing, S.6
Raine, C.S.7
Rowitch, D.H.8
Franklin, R.J.9
Stiles, C.D.10
-
3
-
-
0035733762
-
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
-
CrossRef Medline
-
Backman SA, Stambolic V, Suzuki A, Haight J, Elia A, Pretorius J, Tsao MS, Shannon P, Bolon B, Ivy GO, MakTW (2001) Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 29:396-403. CrossRef Medline
-
(2001)
Nat Genet
, vol.29
, pp. 396-403
-
-
Backman, S.A.1
Stambolic, V.2
Suzuki, A.3
Haight, J.4
Elia, A.5
Pretorius, J.6
Tsao, M.S.7
Shannon, P.8
Bolon, B.9
Ivy, G.O.10
Mak, T.W.11
-
4
-
-
79959681732
-
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
-
CrossRef Medline
-
Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP, Sun GJ, Ming GL, Song H (2011) In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell 145:1142-1155. CrossRef Medline
-
(2011)
Cell
, vol.145
, pp. 1142-1155
-
-
Bonaguidi, M.A.1
Wheeler, M.A.2
Shapiro, J.S.3
Stadel, R.P.4
Sun, G.J.5
Ming, G.L.6
Song, H.7
-
5
-
-
33845296559
-
Modeling early cortical serotonergic deficits in autism
-
CrossRef Medline
-
Boylan CB, Blue ME, Hohmann CF (2007) Modeling early cortical serotonergic deficits in autism. Behav Brain Res 176:94 -108. CrossRef Medline
-
(2007)
Behav Brain Res
, vol.176
, pp. 94-108
-
-
Boylan, C.B.1
Blue, M.E.2
Hohmann, C.F.3
-
6
-
-
0035034603
-
Inactivation of the betacatenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
-
Medline
-
Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R (2001) Inactivation of the betacatenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128: 1253-1264. Medline
-
(2001)
Development
, vol.128
, pp. 1253-1264
-
-
Brault, V.1
Moore, R.2
Kutsch, S.3
Ishibashi, M.4
Rowitch, D.H.5
McMahon, A.P.6
Sommer, L.7
Boussadia, O.8
Kemler, R.9
-
7
-
-
20244367771
-
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
-
CrossRef Medline
-
Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C (2005) Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet 42:318 -321. CrossRef Medline
-
(2005)
J Med Genet
, vol.42
, pp. 318-321
-
-
Butler, M.G.1
Dasouki, M.J.2
Zhou, X.P.3
Talebizadeh, Z.4
Brown, M.5
Takahashi, T.N.6
Miles, J.H.7
Wang, C.H.8
Stratton, R.9
Pilarski, R.10
Eng, C.11
-
8
-
-
34250812575
-
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
-
CrossRef Medline
-
Buxbaum JD, Cai G, Chaste P, Nygren G, Goldsmith J, Reichert J, Anckarsater H, Rastam M, Smith CJ, Silverman JM, Anckarsäter H, Rastam M, Smith CJ, Silverman JM, Hollander E, Leboyer M, Gillberg C, Verloes A, Betancur C (2007) Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am J Med Genet B Neuropsychiatr Genet 144B:484-491. CrossRef Medline
-
(2007)
Am J Med Genet B Neuropsychiatr Genet
, vol.144 B
, pp. 484-491
-
-
Buxbaum, J.D.1
Cai, G.2
Chaste, P.3
Nygren, G.4
Goldsmith, J.5
Reichert, J.6
Anckarsater, H.7
Rastam, M.8
Smith, C.J.9
Silverman, J.M.10
Anckarsäter, H.11
Rastam, M.12
Smith, C.J.13
Silverman, J.M.14
Hollander, E.15
Leboyer, M.16
Gillberg, C.17
Verloes, A.18
Betancur, C.19
-
9
-
-
11844251366
-
Localized enlargement of the frontal cortex in early autism
-
CrossRef Medline
-
Carper RA, Courchesne E (2005) Localized enlargement of the frontal cortex in early autism. Biol Psychiatry 57:126 -133. CrossRef Medline
-
(2005)
Biol Psychiatry
, vol.57
, pp. 126-133
-
-
Carper, R.A.1
Courchesne, E.2
-
10
-
-
0036677965
-
Cerebral lobes in autism: Early hyperplasia and abnormal age effects
-
CrossRef Medline
-
Carper RA, Moses P, Tigue ZD, Courchesne E (2002) Cerebral lobes in autism: early hyperplasia and abnormal age effects. Neuroimage 16:1038- 1051. CrossRef Medline
-
(2002)
Neuroimage
, vol.16
, pp. 1038-1051
-
-
Carper, R.A.1
Moses, P.2
Tigue, Z.D.3
Courchesne, E.4
-
11
-
-
0037135177
-
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
-
CrossRef Medline
-
Chenn A, WalshCA (2002) Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297:365-369. CrossRef Medline
-
(2002)
Science
, vol.297
, pp. 365-369
-
-
Chenn, A.1
Walsh, C.A.2
-
12
-
-
84859220108
-
Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages
-
CrossRef Medline
-
Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E (2012) Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet 8:e1002592. CrossRef Medline
-
(2012)
PLoS Genet
, vol.8
-
-
Chow, M.L.1
Pramparo, T.2
Winn, M.E.3
Barnes, C.C.4
Li, H.R.5
Weiss, L.6
Fan, J.B.7
Murray, S.8
April, C.9
Belinson, H.10
Fu, X.D.11
Wynshaw-Boris, A.12
Schork, N.J.13
Courchesne, E.14
-
13
-
-
24944568790
-
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
-
CrossRef Medline
-
Chung JH, Eng C (2005) Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 65:8096-8100. CrossRef Medline
-
(2005)
Cancer Res
, vol.65
, pp. 8096-8100
-
-
Chung, J.H.1
Eng, C.2
-
14
-
-
84861986053
-
Wnt/beta-catenin signaling and disease
-
CrossRef Medline
-
Clevers H, Nusse R (2012) Wnt/beta-catenin signaling and disease. Cell 149: 1192-1205. CrossRef Medline
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
15
-
-
84902344967
-
Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests
-
CrossRef Medline
-
Clipperton-Allen AE, Page DT (2014) Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests. Hum Mol Genet 23:3490 -3505. CrossRef Medline
-
(2014)
Hum Mol Genet
, vol.23
, pp. 3490-3505
-
-
Clipperton-Allen, A.E.1
Page, D.T.2
-
16
-
-
0036348598
-
Abnormal early brain development in autism
-
Courchesne E (2002) Abnormal early brain development in autism. Mol Psychiatry 7[Suppl 2]:S21-S23.
-
(2002)
Mol Psychiatry
, vol.7
, pp. S21-S23
-
-
Courchesne, E.1
-
17
-
-
50849130596
-
Mapping early brain development in autism
-
CrossRef Medline
-
Courchesne E, Pierce K, Schumann CM, Redcay E, Buckwalter JA, Kennedy DP, Morgan J (2007) Mapping early brain development in autism. Neuron 56:399-413. CrossRef Medline
-
(2007)
Neuron
, vol.56
, pp. 399-413
-
-
Courchesne, E.1
Pierce, K.2
Schumann, C.M.3
Redcay, E.4
Buckwalter, J.A.5
Kennedy, D.P.6
Morgan, J.7
-
18
-
-
80755130317
-
Neuron number and size in prefrontal cortex of children with autism
-
CrossRef Medline
-
Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K (2011) Neuron number and size in prefrontal cortex of children with autism. JAMA 306:2001-2010. CrossRef Medline
-
(2011)
JAMA
, vol.306
, pp. 2001-2010
-
-
Courchesne, E.1
Mouton, P.R.2
Calhoun, M.E.3
Semendeferi, K.4
Ahrens-Barbeau, C.5
Hallet, M.J.6
Barnes, C.C.7
Pierce, K.8
-
19
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
CrossRef Medline
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789. CrossRef Medline
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
20
-
-
84868686559
-
Diagnostic exome sequencing in persons with severe intellectual disability
-
CrossRef Medline
-
de Ligt J, Willemsen MH, van Bon BW, Kleefstra T, Yntema HG, Kroes T, Vulto-van Silfhout AT, Koolen DA, de Vries P, Gilissen C, del Rosario M, Hoischen A, Scheffer H, de Vries BB, Brunner HG, Veltman JA, Vissers LE (2012) Diagnostic exome sequencing in persons with severe intellectual disability. N Engl J Med 367:1921-1929. CrossRef Medline
-
(2012)
N Engl J Med
, vol.367
, pp. 1921-1929
-
-
de Ligt, J.1
Willemsen, M.H.2
van Bon, B.W.3
Kleefstra, T.4
Yntema, H.G.5
Kroes, T.6
Vulto-Van Silfhout, A.T.7
Koolen, D.A.8
de Vries, P.9
Gilissen, C.10
del Rosario, M.11
Hoischen, A.12
Scheffer, H.13
de Vries, B.B.14
Brunner, H.G.15
Veltman, J.A.16
Vissers, L.E.17
-
21
-
-
34247398258
-
PTEN, a general negative regulator of cyclin D expression
-
CrossRef Medline
-
Diao L, Chen YG (2007) PTEN, a general negative regulator of cyclin D expression. Cell Res 17:291-292. CrossRef Medline
-
(2007)
Cell Res
, vol.17
, pp. 291-292
-
-
Diao, L.1
Chen, Y.G.2
-
22
-
-
84899933811
-
A new intellectual disability syndrome caused by CTNNB1 haploinsufficiency
-
CrossRef Medline
-
Dubruc E, Putoux A, Labalme A, Rougeot C, Sanlaville D, Edery P (2014) A new intellectual disability syndrome caused by CTNNB1 haploinsufficiency. Am J Med Genet A 164A:1571-1575. CrossRef Medline
-
(2014)
Am J Med Genet A
, vol.164 A
, pp. 1571-1575
-
-
Dubruc, E.1
Putoux, A.2
Labalme, A.3
Rougeot, C.4
Sanlaville, D.5
Edery, P.6
-
23
-
-
7144223432
-
PTEN mutations in gliomas and glioneuronal tumors
-
CrossRef Medline
-
Duerr EM, Rollbrocker B, Hayashi Y, Peters N, Meyer-Puttlitz B, Louis DN, Schramm J, Wiestler OD, Parsons R, Eng C, von Deimling A (1998) PTEN mutations in gliomas and glioneuronal tumors. Oncogene 16: 2259-2264. CrossRef Medline
-
(1998)
Oncogene
, vol.16
, pp. 2259-2264
-
-
Duerr, E.M.1
Rollbrocker, B.2
Hayashi, Y.3
Peters, N.4
Meyer-Puttlitz, B.5
Louis, D.N.6
Schramm, J.7
Wiestler, O.D.8
Parsons, R.9
Eng, C.10
von Deimling, A.11
-
24
-
-
84892406594
-
Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum
-
CrossRef Medline
-
Edmonson C, Ziats MN, Rennert OM (2014) Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum. Mol Autism 5:3. CrossRef Medline
-
(2014)
Mol Autism
, vol.5
, pp. 3
-
-
Edmonson, C.1
Ziats, M.N.2
Rennert, O.M.3
-
25
-
-
84915783802
-
Overproduction of upper-layer neurons in the neocortex leads to autismlike features in mice
-
CrossRef Medline
-
Fang WQ, Chen WW, Jiang L, Liu K, Yung WH, Fu AK, Ip NY (2014) Overproduction of upper-layer neurons in the neocortex leads to autismlike features in mice. Cell Rep 9:1635-1643. CrossRef Medline
-
(2014)
Cell Rep
, vol.9
, pp. 1635-1643
-
-
Fang, W.Q.1
Chen, W.W.2
Jiang, L.3
Liu, K.4
Yung, W.H.5
Fu, A.K.6
Ip, N.Y.7
-
26
-
-
78650255796
-
A sensitive and bright single-cell resolution live imaging reporter of Wnt/β-catenin signaling in the mouse
-
CrossRef Medline
-
Ferrer-Vaquer A, Piliszek A, Tian G, Aho RJ, Dufort D, Hadjantonakis AK (2010) A sensitive and bright single-cell resolution live imaging reporter of Wnt/β-catenin signaling in the mouse.BMCDev Biol 10:121. CrossRef Medline
-
(2010)
BMCDev Biol
, vol.10
, pp. 121
-
-
Ferrer-Vaquer, A.1
Piliszek, A.2
Tian, G.3
Aho, R.J.4
Dufort, D.5
Hadjantonakis, A.K.6
-
27
-
-
7444264727
-
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
-
CrossRef Medline
-
Fraser MM, Zhu X, Kwon CH, Uhlmann EJ, Gutmann DH, Baker SJ (2004) Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res 64:7773-7779. CrossRef Medline
-
(2004)
Cancer Res
, vol.64
, pp. 7773-7779
-
-
Fraser, M.M.1
Zhu, X.2
Kwon, C.H.3
Uhlmann, E.J.4
Gutmann, D.H.5
Baker, S.J.6
-
28
-
-
84940434964
-
Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism
-
Advance online publication. Accessed Oct. 7, 2014. CrossRef Medline
-
Frazier TW, Embacher R, Tilot AK, Koenig K, Mester J, Eng C (2014) Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism. Mol Psychiatry. Advance online publication. Accessed Oct. 7, 2014. doi: 10.1038/mp.2014.125. CrossRef Medline
-
(2014)
Mol Psychiatry.
-
-
Frazier, T.W.1
Embacher, R.2
Tilot, A.K.3
Koenig, K.4
Mester, J.5
Eng, C.6
-
29
-
-
0033572644
-
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
-
CrossRef Medline
-
Goberdhan DC, Paricio N, Goodman EC, Mlodzik M, Wilson C (1999) Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev 13: 3244-3258. CrossRef Medline
-
(1999)
Genes Dev
, vol.13
, pp. 3244-3258
-
-
Goberdhan, D.C.1
Paricio, N.2
Goodman, E.C.3
Mlodzik, M.4
Wilson, C.5
-
30
-
-
0036703466
-
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage
-
Medline
-
Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein JL, Jones KR (2002) Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22:6309-6314. Medline
-
(2002)
J Neurosci
, vol.22
, pp. 6309-6314
-
-
Gorski, J.A.1
Talley, T.2
Qiu, M.3
Puelles, L.4
Rubenstein, J.L.5
Jones, K.R.6
-
31
-
-
0035824396
-
Negative regulation of neural stem/ progenitor cell proliferation by the Pten tumor suppressor gene in vivo
-
CrossRef Medline
-
Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H (2001) Negative regulation of neural stem/ progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294:2186 -2189. CrossRef Medline
-
(2001)
Science
, vol.294
, pp. 2186-2189
-
-
Groszer, M.1
Erickson, R.2
Scripture-Adams, D.D.3
Lesche, R.4
Trumpp, A.5
Zack, J.A.6
Kornblum, H.I.7
Liu, X.8
Wu, H.9
-
32
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
CrossRef Medline
-
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11:859-871. CrossRef Medline
-
(2006)
Dev Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
33
-
-
28544442720
-
Magnetic resonance imaging and head circumference study of brain size in autism: Birth through age 2 years
-
CrossRef Medline
-
Hazlett HC, Poe M, Gerig G, Smith RG, Provenzale J, Ross A, Gilmore J, Piven J (2005) Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Arch Gen Psychiatry 62: 1366-1376. CrossRef Medline
-
(2005)
Arch Gen Psychiatry
, vol.62
, pp. 1366-1376
-
-
Hazlett, H.C.1
Poe, M.2
Gerig, G.3
Smith, R.G.4
Provenzale, J.5
Ross, A.6
Gilmore, J.7
Piven, J.8
-
34
-
-
14944342993
-
Isotropic fractionator: A simple, rapid method for the quantification of total cell and neuron numbers in the brain
-
CrossRef Medline
-
Herculano-Houzel S, Lent R (2005) Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J Neurosci 25:2518 -2521. CrossRef Medline
-
(2005)
J Neurosci
, vol.25
, pp. 2518-2521
-
-
Herculano-Houzel, S.1
Lent, R.2
-
35
-
-
34247171828
-
GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN
-
CrossRef Medline
-
Huang W, Chang HY, Fei T, Wu H, Chen YG (2007) GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene 26:2471-2482. CrossRef Medline
-
(2007)
Oncogene
, vol.26
, pp. 2471-2482
-
-
Huang, W.1
Chang, H.Y.2
Fei, T.3
Wu, H.4
Chen, Y.G.5
-
36
-
-
0030601207
-
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
-
CrossRef Medline
-
Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S (1996) A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys ResCommun 224:855- 862. CrossRef Medline
-
(1996)
Biochem Biophys ResCommun
, vol.224
, pp. 855-862
-
-
Imai, Y.1
Ibata, I.2
Ito, D.3
Ohsawa, K.4
Kohsaka, S.5
-
37
-
-
0000984981
-
Autistic disturbances of affective contact
-
Kanner L (1943) Autistic disturbances of affective contact. Nervous Child 2:217-250.
-
(1943)
Nervous Child
, vol.2
, pp. 217-250
-
-
Kanner, L.1
-
38
-
-
84866273318
-
Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse
-
CrossRef Medline
-
Kazdoba TM, Sunnen CN, Crowell B, Lee GH, Anderson AE, D'Arcangelo G (2012) Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse. Dev Neurosci 34:198- 209. CrossRef Medline
-
(2012)
Dev Neurosci
, vol.34
, pp. 198-209
-
-
Kazdoba, T.M.1
Sunnen, C.N.2
Crowell, B.3
Lee, G.H.4
Anderson, A.E.5
D'Arcangelo, G.6
-
39
-
-
84874097245
-
Macrocephaly as a clinical indicator of genetic subtypes in autism
-
CrossRef Medline
-
Klein S, Sharifi-Hannauer P, Martinez-Agosto JA (2013) Macrocephaly as a clinical indicator of genetic subtypes in autism. Autism Res 6:51-56. CrossRef Medline
-
(2013)
Autism Res
, vol.6
, pp. 51-56
-
-
Klein, S.1
Sharifi-Hannauer, P.2
Martinez-Agosto, J.A.3
-
40
-
-
67651036549
-
The glial nature of embryonic and adult neural stem cells
-
CrossRef Medline
-
Kriegstein A, Alvarez-Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32:149-184. CrossRef Medline
-
(2009)
Annu Rev Neurosci
, vol.32
, pp. 149-184
-
-
Kriegstein, A.1
Alvarez-Buylla, A.2
-
41
-
-
0035734381
-
Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
-
CrossRef Medline
-
KwonCH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ (2001) Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 29:404-411. CrossRef Medline
-
(2001)
Nat Genet
, vol.29
, pp. 404-411
-
-
Kwon, C.H.1
Zhu, X.2
Zhang, J.3
Knoop, L.L.4
Tharp, R.5
Smeyne, R.J.6
Eberhart, C.G.7
Burger, P.C.8
Baker, S.J.9
-
42
-
-
0036195102
-
Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene
-
CrossRef Medline
-
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Sun H, Liu X,WuH (2002) Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32:148 -149. CrossRef Medline
-
(2002)
Genesis
, vol.32
, pp. 148-149
-
-
Lesche, R.1
Groszer, M.2
Gao, J.3
Wang, Y.4
Messing, A.5
Sun, H.6
Liu, X.7
Wu, H.8
-
43
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
CrossRef Medline
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947. CrossRef Medline
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
44
-
-
0036279763
-
PTENin neural precursor cells: Regulation of migration, apoptosis, and proliferation
-
CrossRef Medline
-
Li L, Liu F, Salmonsen RA, Turner TK, Litofsky NS, Di Cristofano A, Pandolfi PP, Jones SN, Recht LD, RossAH (2002) PTENin neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol Cell Neurosci 20:21-29. CrossRef Medline
-
(2002)
Mol Cell Neurosci
, vol.20
, pp. 21-29
-
-
Li, L.1
Liu, F.2
Salmonsen, R.A.3
Turner, T.K.4
Litofsky, N.S.5
Di Cristofano, A.6
Pandolfi, P.P.7
Jones, S.N.8
Recht, L.D.9
Ross, A.H.10
-
45
-
-
77955626857
-
Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly
-
CrossRef Medline
-
McBride KL, Varga EA, Pastore MT, Prior TW, Manickam K, Atkin JF, Herman GE (2010) Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly. Autism Res 3:137-141. CrossRef Medline
-
(2010)
Autism Res
, vol.3
, pp. 137-141
-
-
McBride, K.L.1
Varga, E.A.2
Pastore, M.T.3
Prior, T.W.4
Manickam, K.5
Atkin, J.F.6
Herman, G.E.7
-
46
-
-
0033547879
-
S-100beta protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis
-
CrossRef Medline
-
Migheli A, Cordera S, Bendotti C, Atzori C, Piva R, Schiffer D (1999) S-100beta protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis. Neurosci Lett 261:25-28. CrossRef Medline
-
(1999)
Neurosci Lett
, vol.261
, pp. 25-28
-
-
Migheli, A.1
Cordera, S.2
Bendotti, C.3
Atzori, C.4
Piva, R.5
Schiffer, D.6
-
47
-
-
77955684004
-
Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
-
CrossRef Medline
-
Morgan JT, Chana G, Pardo CA, Achim C, Semendeferi K, Buckwalter J, Courchesne E, Everall IP (2010) Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol Psychiatry 68:368 -376. CrossRef Medline
-
(2010)
Biol Psychiatry
, vol.68
, pp. 368-376
-
-
Morgan, J.T.1
Chana, G.2
Pardo, C.A.3
Achim, C.4
Semendeferi, K.5
Buckwalter, J.6
Courchesne, E.7
Everall, I.P.8
-
48
-
-
0028784940
-
Apoptosis in the developing CNS
-
CrossRef Medline
-
Naruse I, KeinoH (1995) Apoptosis in the developing CNS. Prog Neurobiol 47:135-155. CrossRef Medline
-
(1995)
Prog Neurobiol
, vol.47
, pp. 135-155
-
-
Naruse, I.1
Keino, H.2
-
49
-
-
0033824729
-
Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia
-
Medline
-
Ohsawa K, Imai Y, Kanazawa H, Sasaki Y, Kohsaka S (2000) Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci 113:3073-3084. Medline
-
(2000)
J Cell Sci
, vol.113
, pp. 3073-3084
-
-
Ohsawa, K.1
Imai, Y.2
Kanazawa, H.3
Sasaki, Y.4
Kohsaka, S.5
-
50
-
-
84871448593
-
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders
-
CrossRef Medline
-
O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG, Carvill G, Kumar A, Lee C, Ankenman K, Munson J, Hiatt JB, Turner EH, Levy R, O'Day DR, Krumm N, Coe BP, Martin BK, Borenstein E, Nickerson DA, et al. (2012) Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science 338:1619 -1622. CrossRef Medline
-
(2012)
Science
, vol.338
, pp. 1619-1622
-
-
O'Roak, B.J.1
Vives, L.2
Fu, W.3
Egertson, J.D.4
Stanaway, I.B.5
Phelps, I.G.6
Carvill, G.7
Kumar, A.8
Lee, C.9
Ankenman, K.10
Munson, J.11
Hiatt, J.B.12
Turner, E.H.13
Levy, R.14
O'Day, D.R.15
Krumm, N.16
Coe, B.P.17
Martin, B.K.18
Borenstein, E.19
Nickerson, D.A.20
more..
-
51
-
-
60549116652
-
Haploinsufficiency for Pten and serotonin transporter cooperatively influences brain size and social behavior
-
CrossRef Medline
-
Page DT, Kuti OJ, Prestia C, SurM (2009) Haploinsufficiency for Pten and serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A 106:1989 -1994. CrossRef Medline
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1989-1994
-
-
Page, D.T.1
Kuti, O.J.2
Prestia, C.3
Sur, M.4
-
52
-
-
0030113118
-
Regional brain enlargement in autism: A magnetic resonance imaging study
-
CrossRef Medline
-
Piven J, Arndt S, Bailey J, Andreasen N (1996) Regional brain enlargement in autism: a magnetic resonance imaging study. J AmAcad Child Adolesc Psychiatry 35:530 -536. CrossRef Medline
-
(1996)
J AmAcad Child Adolesc Psychiatry
, vol.35
, pp. 530-536
-
-
Piven, J.1
Arndt, S.2
Bailey, J.3
Andreasen, N.4
-
53
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
CrossRef Medline
-
Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R (1999) Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A 96:1563-1568. CrossRef Medline
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
54
-
-
0042971700
-
PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1
-
CrossRef Medline
-
Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM (2003) PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol 23:6139-6149. CrossRef Medline
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6139-6149
-
-
Radu, A.1
Neubauer, V.2
Akagi, T.3
Hanafusa, H.4
Georgescu, M.M.5
-
55
-
-
84884671852
-
Compared to what? Early brain overgrowth in autism and the perils of population norms
-
CrossRef Medline
-
Raznahan A, Wallace GL, Antezana L, Greenstein D, Lenroot R, Thurm A, Gozzi M, Spence S, Martin A, Swedo SE, Giedd JN (2013) Compared to what? Early brain overgrowth in autism and the perils of population norms. Biol Psychiatry 74:563-575. CrossRef Medline
-
(2013)
Biol Psychiatry
, vol.74
, pp. 563-575
-
-
Raznahan, A.1
Wallace, G.L.2
Antezana, L.3
Greenstein, D.4
Lenroot, R.5
Thurm, A.6
Gozzi, M.7
Spence, S.8
Martin, A.9
Swedo, S.E.10
Giedd, J.N.11
-
56
-
-
74049088121
-
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
-
CrossRef Medline
-
Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand-Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauché S, Hantaï D, Mueller M, Kozma SC, et al. (2009) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J Cell Biol 187:859 - 874. CrossRef Medline
-
(2009)
J Cell Biol
, vol.187
, pp. 859-874
-
-
Risson, V.1
Mazelin, L.2
Roceri, M.3
Sanchez, H.4
Moncollin, V.5
Corneloup, C.6
Richard-Bulteau, H.7
Vignaud, A.8
Baas, D.9
Defour, A.10
Freyssenet, D.11
Tanti, J.F.12
Le-Marchand-Brustel, Y.13
Ferrier, B.14
Conjard-Duplany, A.15
Romanino, K.16
Bauché, S.17
Hantaï, D.18
Mueller, M.19
Kozma, S.C.20
more..
-
57
-
-
77949826586
-
Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism
-
CrossRef Medline
-
Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E (2010) Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci 30:4419-4427. CrossRef Medline
-
(2010)
J Neurosci
, vol.30
, pp. 4419-4427
-
-
Schumann, C.M.1
Bloss, C.S.2
Barnes, C.C.3
Wideman, G.M.4
Carper, R.A.5
Akshoomoff, N.6
Pierce, K.7
Hagler, D.8
Schork, N.9
Lord, C.10
Courchesne, E.11
-
58
-
-
0036499716
-
PTEN: A new twist on beta-catenin?
-
CrossRef Medline
-
Stambolic V (2002) PTEN: a new twist on beta-catenin? Trends Pharmacol Sci 23:104 -106. CrossRef Medline
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 104-106
-
-
Stambolic, V.1
-
59
-
-
84896829795
-
A genotype-first approach to defining the subtypes of a complex disease
-
CrossRef Medline
-
Stessman HA, Bernier R, Eichler EE (2014) A genotype-first approach to defining the subtypes of a complex disease. Cell 156:872- 877. CrossRef Medline
-
(2014)
Cell
, vol.156
, pp. 872-877
-
-
Stessman, H.A.1
Bernier, R.2
Eichler, E.E.3
-
60
-
-
4344698040
-
PTENless means more
-
CrossRef Medline
-
Stiles B, Groszer M, Wang S, Jiao J, Wu H (2004) PTENless means more. Dev Biol 273:175-184. CrossRef Medline
-
(2004)
Dev Biol
, vol.273
, pp. 175-184
-
-
Stiles, B.1
Groszer, M.2
Wang, S.3
Jiao, J.4
Wu, H.5
-
61
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/ protein kinase B signaling pathway
-
CrossRef Medline
-
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/ protein kinase B signaling pathway. Proc Natl Acad Sci U S A 96:6199- 6204. CrossRef Medline
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.M.3
Liliental, J.4
Zhang, H.5
Gao, J.6
Gavrilova, N.7
Mueller, B.8
Liu, X.9
Wu, H.10
-
62
-
-
84871939639
-
Microglial activation in young adults with autism spectrum disorder
-
CrossRef Medline
-
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N (2013) Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry 70:49 -58. CrossRef Medline
-
(2013)
JAMA Psychiatry
, vol.70
, pp. 49-58
-
-
Suzuki, K.1
Sugihara, G.2
Ouchi, Y.3
Nakamura, K.4
Futatsubashi, M.5
Takebayashi, K.6
Yoshihara, Y.7
Omata, K.8
Matsumoto, K.9
Tsuchiya, K.J.10
Iwata, Y.11
Tsujii, M.12
Sugiyama, T.13
Mori, N.14
-
63
-
-
14444269482
-
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
-
Medline
-
Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, et al. (1997) MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 57:5221-5225. Medline
-
(1997)
Cancer Res
, vol.57
, pp. 5221-5225
-
-
Teng, D.H.1
Hu, R.2
Lin, H.3
Davis, T.4
Iliev, D.5
Frye, C.6
Swedlund, B.7
Hansen, K.L.8
Vinson, V.L.9
Gumpper, K.L.10
Ellis, L.11
El-Naggar, A.12
Frazier, M.13
Jasser, S.14
Langford, L.A.15
Lee, J.16
Mills, G.B.17
Pershouse, M.A.18
Pollack, R.E.19
Tornos, C.20
more..
-
64
-
-
44949144048
-
CHD8 is an ATPdependent chromatin remodeling factor that regulates beta-catenin target genes
-
CrossRef Medline
-
Thompson BA, Tremblay V, Lin G, Bochar DA (2008) CHD8 is an ATPdependent chromatin remodeling factor that regulates beta-catenin target genes. Mol Cell Biol 28:3894 -3904. CrossRef Medline
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3894-3904
-
-
Thompson, B.A.1
Tremblay, V.2
Lin, G.3
Bochar, D.A.4
-
65
-
-
62149104335
-
The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly
-
CrossRef Medline
-
Varga EA, Pastore M, Prior T, Herman GE, McBride KL (2009) The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly. Genet Med 11: 111-117. CrossRef Medline
-
(2009)
Genet Med
, vol.11
, pp. 111-117
-
-
Varga, E.A.1
Pastore, M.2
Prior, T.3
Herman, G.E.4
McBride, K.L.5
-
66
-
-
11144230769
-
Neuroglial activation and neuroinflammation in the brain of patients with autism
-
CrossRef Medline
-
Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA (2005) Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 57:67- 81. CrossRef Medline
-
(2005)
Ann Neurol
, vol.57
, pp. 67-81
-
-
Vargas, D.L.1
Nascimbene, C.2
Krishnan, C.3
Zimmerman, A.W.4
Pardo, C.A.5
-
67
-
-
79959262465
-
Transcriptomic analysis of autistic brain reveals convergent molecular pathology
-
CrossRef Medline
-
Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH (2011) Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 474:380- 384. CrossRef Medline
-
(2011)
Nature
, vol.474
, pp. 380-384
-
-
Voineagu, I.1
Wang, X.2
Johnston, P.3
Lowe, J.K.4
Tian, Y.5
Horvath, S.6
Mill, J.7
Cantor, R.M.8
Blencowe, B.J.9
Geschwind, D.H.10
-
68
-
-
34249935820
-
Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism
-
CrossRef Medline
-
Wassink TH, Hazlett HC, Epping EA, Arndt S, Dager SR, Schellenberg GD, Dawson G, Piven J (2007) Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. Arch Gen Psychiatry 64:709 -717. CrossRef Medline
-
(2007)
Arch Gen Psychiatry
, vol.64
, pp. 709-717
-
-
Wassink, T.H.1
Hazlett, H.C.2
Epping, E.A.3
Arndt, S.4
Dager, S.R.5
Schellenberg, G.D.6
Dawson, G.7
Piven, J.8
-
69
-
-
1942437399
-
Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas
-
CrossRef Medline
-
Yokoo H, Nobusawa S, Takebayashi H, Ikenaka K, Isoda K, Kamiya M, Sasaki A, Hirato J, Nakazato Y (2004) Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. Am J Pathol 164:1717-1725. CrossRef Medline
-
(2004)
Am J Pathol
, vol.164
, pp. 1717-1725
-
-
Yokoo, H.1
Nobusawa, S.2
Takebayashi, H.3
Ikenaka, K.4
Isoda, K.5
Kamiya, M.6
Sasaki, A.7
Hirato, J.8
Nakazato, Y.9
-
70
-
-
84891629372
-
The glial perspective of autism spectrum disorders
-
CrossRef Medline
-
Zeidán-Chuliá F, Salmina AB, Malinovskaya NA, Noda M, Verkhratsky A, Moreira JC (2014) The glial perspective of autism spectrum disorders. Neurosci Biobehav Rev 38:160 -172. CrossRef Medline
-
(2014)
Neurosci Biobehav Rev
, vol.38
, pp. 160-172
-
-
Zeidán-Chuliá, F.1
Salmina, A.B.2
Malinovskaya, N.A.3
Noda, M.4
Verkhratsky, A.5
Moreira, J.C.6
-
71
-
-
84868198811
-
PTEN signaling in autism spectrum disorders
-
CrossRef Medline
-
Zhou J, Parada LF (2012) PTEN signaling in autism spectrum disorders. Curr Opin Neurobiol 22:873- 879. CrossRef Medline
-
(2012)
Curr Opin Neurobiol
, vol.22
, pp. 873-879
-
-
Zhou, J.1
Parada, L.F.2
-
72
-
-
0028814248
-
Delayed maturation of the frontal cortex in childhood autism
-
CrossRef Medline
-
Zilbovicius M, Garreau B, Samson Y, Remy P, Barthélémy C, Syrota A, Lelord G (1995) Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 152:248 -252. CrossRef Medline
-
(1995)
Am J Psychiatry
, vol.152
, pp. 248-252
-
-
Zilbovicius, M.1
Garreau, B.2
Samson, Y.3
Remy, P.4
Barthélémy, C.5
Syrota, A.6
Lelord, G.7
|