Regional Brain Enlargement in Autism: A Magnetic Resonance Imaging Study

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 35, Issue 4, 1996, Pages 530-536

  Piven, Joseph ^a,b   Arndt, Stephan ^a   Bailey, James ^a   Andreasen, Nancy ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Autism; Brain; Development; Magnetic resonance imaging

Indexed keywords

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ARTICLE; AUTISM; BRAIN CORTEX; CASE CONTROL STUDY; FEMALE; HUMAN; IMAGE PROCESSING; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; UNITED STATES;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; AUTISTIC DISORDER; CASE-CONTROL STUDIES; CEREBRAL CORTEX; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IOWA; MAGNETIC RESONANCE IMAGING; MALE;

EID: 0030113118     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004583-199604000-00020     Document Type: Article

References (39)

1. American Psychiatric Association (1987), Diagnostic and Statistical Manual of Mental Disorders, 3rd edition-revised (DSM-III-R). Washington, DC: American Psychiatric Association
2. Andreasen NC, Cizadlo T, Harris G et al. (1993), Voxel processing techniques for the antemortem study of neuroanatomy and neuropathology using magnetic resonance imaging. J Neuropsychiatry Clin Neurosci 5:121-130
3. Andreasen NC, Cohen G, Harris G et al. (1992a), Image processing for the study of brain structure and function: problems and programs. J Neuropsychiatry Clin Neurosci 4:125-133
4. Andreasen NC, Flashman L, Flaum M et al. (1994a), Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 272:1763-1769
5. Andreasen NC, Flaum M, Arndt SV (1992b), The Comprehensive Assessment of Symptoms and History (CASH): an instrument for assessing psychopathology and diagnosis. Arch Gen Psychiatry 49:515-623
6. Andreasen NC, Harris G, Cizadlo T et al. (1994b), Techniques for measuring sulcal/gyral patterns in the brain as visualized through MR scanning: BRAINPLOT and BRIANMAP. Proc Natl Acad Sci U S A 900:93-97
7. Andreasen NC, Rajaprabhakaran R, Cizadlo T, eds (1994c), Automated Atlas-Based Dissection of Human Brain from MR Images. San Francisco, CA: Society of Magnetic Resonance in Medicine
8. Andreasen NC, Swayze V, Flaum M, Yates WR, Arndt S, McChesney C (1990), Ventricular enlargement in schizophrenia evaluated with CT scanning: ejects of gender, age, and stage of illness. Arch Gen Psychiafry 47:1054-1059
9. Arndt S, Swayze V, Cizadlo T et al. (1994), Evaluating and validating two methods for estimating brain structure volumes: tessellation and simple pixel counting. Neuroimage 1:191-198
10. Arthur G (1952), The Arthur Adaptation of the Leiter International Performance Scale. Chicago: Psychological Service Center Press
11. Bailey A, LeCouteur A, Gottesman I et al. (1995), Autism as a strongly genetic disorder: evidence from a Brirish twin study. Psychol Med 25:63-77
12. Bailey A, Luthert P, Bolton P, LeCouteur A, Rutter M (1993), Autism and megalencephaly. Lancet 34:1225-1226
13. Bauman ML, Kemper TL (1994), Neuroanatomic observations of the brain in autism. In: The Neurobiology of Autism, Bauman ML, Kemper TL, eds. Baltimore: Johns Hopkins University Press, pp 119-145
14. Castellanos XF, Giedd JN, Eckburg P et al. (1994), Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder. Am J Psychiatry 151:1791-1796
15. Cizadlo T, Andreasen NC, Zeien G et al. (1994), Image registration issues in the analysis of multiple-injection 150H20 PET studies: BRAINFIT. Presented at Society Photo-Optical Instrumentation Engineers, International Society for Optical Engineering, 2168:423-430
16. Cohen G, Andreasen NC, Alliger R et al. (1992), Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Res Neuroimaging 46:33-51
17. Coleman PD, Romano J, Lapham L, Simon W (1985), Cell counts in cerebral cortex of an autistic patient. J Autism Dev Disord 15:245-255
18. Damasio AR, Mauer RG (1978), A neurological model for childhood autism. Arch Neurol 35:777-863
19. Filipek PA, Richelme C, Kennedy DN et al. (1992), Morphometric analysis of the brain in developmental language disorders and autism (abstract). Ann Neurol 32:475
20. Flaum M, Arndt S, Andreasen NC (1990), The role of gender in studies of ventricular enlargement in schizophrenia: a predominantly male effect. Am J Psychiatry 147:1327-1332
21. LeCouteur A, Rutter M, Lord C et al. (1989), Autism Diagnostic Interview: a standardized investigator-based instrument. J Autism Dev Disord 19:363-387
22. Lord C, Schopler E (1987), Neurobiological implications of sex differences in autism. In: Neurobiological Issues in Autism, Schopler E, Mesibov BG, eds. New York: Plenum Press, pp 191-211
23. Lotter V (1966), Epidemiology of autistic conditions in young children: I. Prevalence. Soc Psychiatry 1:124-137
24. Minshew NJ, Dombrowski SM (1994), In vivo neuroanatomy of autism: neuroimagmg studies. In: The Neurobiology of Autism, Bauman ML, Kemper TL, eds. Baltimore: Johns Hopkins University Press, pp 66-85
25. Ozonoff S, Pennington BF, Rogers SJ (1991), Executive function deficits in high-functioning autistic individuals: relationship to theory of mind. J Child Psychol Psychiatry 32:1081-1105
26. Piven J, Arndt S, Bailey J, Havercamp S, Andreasen N, Palmer P (1995), An MRI study of brain size in autism. Am J Psychiatry 152:1145-1149
27. Piven J, Folstein S (1994), The genetics of autism. In: The Neurobiology of Autism, Bauman ML, Kemper TL, eds. Baltimore: Johns Hopkins University Press, pp 18-44
28. Piven J, Nehme E, Simon J, Barta P, Pearlson G, Folstein SE (1992), Magnetic resonance imaging in autism: measurement of the cerebellum, pons, and fourth ventricle. Biol Psychiatry 31:491-504
29. Ritvo ER, Jorde LB, Mason-Brothers A et al. (1989), The UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counseling. Am J Psychiatry 146:1032-1036
30. SAS Institute Inc (1992), SAS/STAT User's Guide, Version (6), 4th ed, Vol 2. Cary, NC: SAS Institute Inc
31. Schultz RT, Cho NK, Staib LH et al. (1994), Brain morphology in normal and dyslexic children: the influence of sex and age. Ann Neurol 35:732-742
32. Shaywitz BA, Shaywitz SE, Pugh KR et al. (1995), Sex differences in the functional organization of the brain for language. Nature 373:607-609
33. Steg JP, Rapoport JL (1975), Minor physical anomalies in normal, neurotic learning disabled, and severely disturbed children. J Autism Child Schizophr 5:299-307
34. Talairach H, Tournoux P, eds (1988), Co-Planar Stereotaxic Atlas of the Human Brain. New York: Thieme Medical Publishers
35. Walker HA (1977), Incidence of minor physical anomaly in autism. J Autism Child Schizophr 7:165-176
36. Wechsler D (1981), Wechsler Adult Intelligence Scale-Revised. San Antonio, TX: The Psychological Corporation
37. Wechsler D (1991), Wechsler Intelligence Scale for Children-III. San Antonio, TX: The Psychological Corporation
38. World Health Organization (1992), Categories F00-F99 mental and behavioural disorders (including disorders of psychological development). Clinical descriptions and diagnostic guidelines. In: International Classification of Diseases, 10 revision. Geneva: World Health Organization
39. Zilbovicius M, Garreau B, Samson Y et al. (1995), Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 158:248-252