PTEN: A new twist on β-catenin?

Trends in Pharmacological Sciences

Volumn 23, Issue 3, 2002, Pages 104-106

  Stambolic, Vuk ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

CANCER; CARCINOGENESIS; CELL ADHESION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; COLORECTAL CANCER; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; SKIN CANCER; TUMOR SUPPRESSOR GENE;

EID: 0036499716     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01984-2     Document Type: Review

References (19)

1. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
2. PTEN: Life as a tumor suppressor
3. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
4. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
5. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
6. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
7. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
8. Genetic control of cell size
9. Tumor suppressor PTEN inhibits nuclear accumulation of β-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation
10. Wnt signaling and cancer
11. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
12. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
13. Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
14. Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
15. Integrin-linked kinase and PINCH: Partners in regulation of cell-extracellular matrix interaction and signal transduction
16. Differential regulation of glycogen synthase kinase 3β by insulin and Wnt signaling
17. Structure of GSK3β reveals a primed phosphorylation mechanism
18. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β)
19. Regulation of PTEN transcription by p53