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Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4839-4845

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

(6) Noha, Stefan M a Fischer, Katrin b Koeberle, Andreas b Garscha, Ulrike b Werz, Oliver b Schuster, Daniela a

a UNIVERSITY OF INNSBRUCK (Austria)

b FRIEDRICH SCHILLER UNIVERSITY JENA (Germany)

Author keywords

3D pharmacophore; Inflammation; Kruskal Wallis test; mPGES 1; Virtual screening

Indexed keywords

ENZYME INHIBITOR; MICROSOMAL PROSTAGLANDIN E2 SYNTHASE 1 INHIBITOR; UNCLASSIFIED DRUG; ISOMERASE; PROSTAGLANDIN E SYNTHASE; PROTEIN BINDING; PTGES PROTEIN, HUMAN;

ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MOLECULAR DOCKING; MULTISTEP VIRTUAL SCREENING PROTOCOL; PHARMACOPHORE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; METABOLISM; MICROSOME; PRECLINICAL STUDY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

BINDING SITES; CELL LINE, TUMOR; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MICROSOMES; MOLECULAR DOCKING SIMULATION; PROSTAGLANDIN-E SYNTHASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84937518562 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.05.045 Document Type: Article

Times cited : (19)

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