Structural basis for induced formation of the inflammatory mediator prostaglandin E2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 32, 2008, Pages 11110-11115

  Jegerschöld, Caroline ^a   Pawelzik, Sven Christian ^b   Purhonen, Pasi ^a   Bhakat, Priyaranjan ^a,e   Gheorghe, Karina Roxana ^a   Gyobu, Nobuhiko ^c   Mitsuoka, Kaoru ^d   Morgenstern, Ralf ^b   Jakobsson, Per Johan ^b   Hebert, Hans ^a  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Japan Biological Information Research Center   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^e CSIRO   (Australia)

Author keywords

Electron crystallography; Inflammation; MAPEG; Membrane protein

Indexed keywords

ARACHIDONIC ACID; GLUTATHIONE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; PROTEIN SUBUNIT;

ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; HUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACID; ARTHRITIS, RHEUMATOID; CATALYSIS; DINOPROSTONE; FEVER; GLUTATHIONE; HUMANS; INFLAMMATION MEDIATORS; INTRAMOLECULAR OXIDOREDUCTASES; LIPID BILAYERS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PAIN; PHOSPHOLIPIDS; PROSTAGLANDIN H2; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49649104307     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802894105     Document Type: Article

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