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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 285-288

Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E 2 synthase-1 inhibitors

(7) Shiro, Tomoya a Takahashi, Hirotada a Kakiguchi, Keisuke a Inoue, Yoshifumi a Masuda, Keiki a Nagata, Hidetaka a Tobe, Masanori a

a DAINIPPON SUMITOMO PHARMA CO LTD (Japan)

Author keywords

COX 1; COX 2; Imidazoquinoline; mPGES 1; PGE 2

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMIDAZOQUINOLINE DERIVATIVE; MF 63; PROSTAGLANDIN E2 SYNTHASE 1 INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMMONIA; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MICROSOMES; MODELS, CHEMICAL; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84655165079 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.11.015 Document Type: Article

Times cited : (44)

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