Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation

Prostaglandins and Other Lipid Mediators

Volumn 107, Issue , 2013, Pages 26-34

  Leclerc, Patrick ^a   Idborg, Helena ^a,b,c   Spahiu, Linda ^a   Larsson, Charlotte ^b,c   Nekhotiaeva, Natalia ^b,c   Wannberg, Johan ^b,c   Stenberg, Patric ^b,c   Korotkova, Marina ^a   Jakobsson, Per Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KDev Exploratory AB   (Sweden)

^c NovaSAID AB   (Sweden)

Author keywords

Air pouch model; Inflammation; Macrophages; Mouse; mPGES 1; PGE2

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS REACTION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INFLAMMATION; LUNG CARCINOMA; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROSTAGLANDIN SYNTHESIS;

AIR POUCH MODEL; INFLAMMATION; MACROPHAGES; MOUSE; MPGES-1; PGE2;

ANIMALS; BENZIMIDAZOLES; CELL LINE, TUMOR; DINOPROSTONE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GENE KNOCKOUT TECHNIQUES; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; ISONIPECOTIC ACIDS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED DBA; MICE, KNOCKOUT; PROSTAGLANDIN H2; RATS; THROMBOXANE B2;

EID: 84889086213     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2013.09.001     Document Type: Article

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