Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1)

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 407-415

  Lauro, Gianluigi ^a   Strocchia, Maria ^a   Terracciano, Stefania ^a   Bruno, Ines ^a   Fischer, Katrin ^b   Pergola, Carlo ^b   Werz, Oliver ^b   Riccio, Raffaele ^a   Bifulco, Giuseppe ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Biginelli reaction; Inflammation; Molecular docking; mPGES 1 inhibitors

Indexed keywords

ISOMERASE INHIBITOR; PROSTAGLANDIN E SYNTHASE 1; PYRIMIDINE DERIVATIVE; ENZYME INHIBITOR; ISOMERASE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E SYNTHASE;

ARTICLE; BIGINELLI REACTION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; MICROWAVE IRRADIATION; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; METABOLISM; PROTEIN SECONDARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINES;

EID: 84899871048     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.061     Document Type: Article

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