Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 10, 2013, Pages 3806-3811

  Sjögren, Tove ^a   Nord, Johan ^b   Ek, Margareta ^a   Johansson, Patrik ^a   Liu, Gang ^b   Geschwindner, Stefan ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Enzyme mechanism; Membrane protein; X ray crystallography

Indexed keywords

MEMBRANE ASSOCIATED PROTEIN INVOLVED IN EICOSANOID AND GLUTATHIONE; MEMBRANE PROTEIN; MONOMER; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIODIVERSITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOSOL; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; MICROSOME; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN METABOLISM; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GLUTATHIONE; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MICROSOMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84874608767     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218504110     Document Type: Article

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