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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7335-7339

Identification of novel mPGES-1 inhibitors through screening of a chemical library

(9) Park, Sung Jun a Han, Seong Gu a Ahsan, Hafiz Muhammad a Lee, Kijae b Lee, Jae Yeol b Shin, Ji Sun b Lee, Kyung Tae b Kang, Nam Suk c Yu, Yeon Gyu a

a Kookmin University (South Korea)

b Kyung Hee University (South Korea)

c Chungnam National University (South Korea)

Author keywords

Anti inflammatory drug; Inhibitors; Modeling; mPGES 1; Screening

Indexed keywords

ISOMERASE INHIBITOR; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR LIBRARY; MOLECULAR MODEL; PROSTAGLANDIN SYNTHESIS INHIBITION;

ANIMALS; BINDING SITES; CELL LINE; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOPOLYSACCHARIDES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870249088 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.10.085 Document Type: Article

Times cited : (22)

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