-
2
-
-
78449253588
-
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives
-
Mitsuhashi S, Takenaka J, Iwamori K, et al. Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives. Bioorg Med Chem Lett 2010;18: 8106-11.
-
(2010)
Bioorg Med Chem Lett
, vol.18
, pp. 8106-8111
-
-
Mitsuhashi, S.1
Takenaka, J.2
Iwamori, K.3
-
3
-
-
0034299527
-
Mycophenolic acid: A one hundred year odyssey from antibiotic to immunosuppressant
-
Bentley R. Mycophenolic acid: a one hundred year odyssey from antibiotic to immunosuppressant. Chem Rev 2000;100:3801-25.
-
(2000)
Chem Rev
, vol.100
, pp. 3801-3825
-
-
Bentley, R.1
-
4
-
-
0019948293
-
Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-b-Dribofuranosylthiazole-4-carboxamide (NSC 286193)
-
Jayaram HN, Dion RL, Glazer RI, et al. Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-b-Dribofuranosylthiazole-4-carboxamide (NSC 286193). Biochem Pharmacol 1982;31:2371-80.
-
(1982)
Biochem Pharmacol
, vol.31
, pp. 2371-2380
-
-
Jayaram, H.N.1
Dion, R.L.2
Glazer, R.I.3
-
5
-
-
0029072097
-
Phosphoinositide signaling in nuclei of Friend cells: Tiazofurin down-regulates phospholipase C beta 1
-
Manzoli L, Billi AM, Gilmour RS, et al. Phosphoinositide signaling in nuclei of Friend cells: tiazofurin down-regulates phospholipase C beta 1. Cancer Res 1995;55:2978-80.
-
(1995)
Cancer Res
, vol.55
, pp. 2978-2980
-
-
Manzoli, L.1
Billi, A.M.2
Gilmour, R.S.3
-
6
-
-
0030916139
-
IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells
-
Vitale M, Zamai L, Falcieri E, et al. IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells. Cytometry 1997;30:61-6.
-
(1997)
Cytometry
, vol.30
, pp. 61-66
-
-
Vitale, M.1
Zamai, L.2
Falcieri, E.3
-
7
-
-
0029909347
-
Molecular mechanisms in the antiproliferative action of taxol and tiazofurin
-
Olah E, Csokay B, Prajda N, et al. Molecular mechanisms in the antiproliferative action of taxol and tiazofurin. Anticancer Res 1996; 16:2469-77.
-
(1996)
Anticancer Res
, vol.16
, pp. 2469-2477
-
-
Olah, E.1
Csokay, B.2
Prajda, N.3
-
8
-
-
0030499593
-
Tiazofurin: Molecular and clinical action
-
Weber G, Prajda N, Abonyi M, et al. Tiazofurin: molecular and clinical action. Anticancer Res 1996;16:3313-22.
-
(1996)
Anticancer Res
, vol.16
, pp. 3313-3322
-
-
Weber, G.1
Prajda, N.2
Abonyi, M.3
-
9
-
-
0034045586
-
Mycophenolate mofetil and its mechanisms of action
-
Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000;47:85-118.
-
(2000)
Immunopharmacology
, vol.47
, pp. 85-118
-
-
Allison, A.C.1
Eugui, E.M.2
-
10
-
-
0025232817
-
Two distinct cDNAs from human IMP dehydrogenase
-
Natsumeda Y, Ohno S, Kawasaki H, et al. Two distinct cDNAs from human IMP dehydrogenase. J Biol Chem 1990;265:5292-5.
-
(1990)
J Biol Chem
, vol.265
, pp. 5292-5295
-
-
Natsumeda, Y.1
Ohno, S.2
Kawasaki, H.3
-
11
-
-
0026546968
-
Selective up-regulation of type II inosine 50-monophosphate dehydrogenase messanger RNA expression in human leukemias
-
Nagai M, Natsumeda Y, Weber G. Selective up-regulation of type II inosine 50-monophosphate dehydrogenase messanger RNA expression in human leukemias. Cancer Res 1992;52:258-61.
-
(1992)
Cancer Res
, vol.52
, pp. 258-261
-
-
Nagai, M.1
Natsumeda, Y.2
Weber, G.3
-
12
-
-
0025961794
-
Expression of human IMP dehydrogenase types i and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines
-
Konno Y, Natsumeda Y, Nagai M, et al. Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines. J Biol Chem 1991;266:506-9.
-
(1991)
J Biol Chem
, vol.266
, pp. 506-509
-
-
Konno, Y.1
Natsumeda, Y.2
Nagai, M.3
-
13
-
-
0001213543
-
Regulation of the human inosine monophosphate dehydrogenase type i gene. Utilization of alternative promoters
-
Gu JJ, Spychala J, Mitchell BS. Regulation of the human inosine monophosphate dehydrogenase type I gene. Utilization of alternative promoters. J Biol Chem 1997;272:4458-66.
-
(1997)
J Biol Chem
, vol.272
, pp. 4458-4466
-
-
Gu, J.J.1
Spychala, J.2
Mitchell, B.S.3
-
14
-
-
36849021519
-
Inosine monophosphate dehydrogenase (IMPDH) as a probe in antiviral drug discovery
-
Nair V, Shu Q. Inosine monophosphate dehydrogenase (IMPDH) as a probe in antiviral drug discovery. Antiviral Chem Chemother 2007;18:245-58.
-
(2007)
Antiviral Chem Chemother
, vol.18
, pp. 245-258
-
-
Nair, V.1
Shu, Q.2
-
15
-
-
33646439982
-
Identification of type i inosine monophosphate dehydrogenase as an antiangiogenic drug target
-
Chong CR, Qian DZ, Pan F, et al. Identification of type I inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem 2006;49:2677-80.
-
(2006)
J Med Chem
, vol.49
, pp. 2677-2680
-
-
Chong, C.R.1
Qian, D.Z.2
Pan, F.3
-
16
-
-
79957943043
-
Rehab of NAD(P)-dependent enzymes with NAD(P)-based inhibitors
-
Felczak K, Pankiewicz KW. Rehab of NAD(P)-dependent enzymes with NAD(P)-based inhibitors. Curr Med Chem 2011;18:1891-908.
-
(2011)
Curr Med Chem
, vol.18
, pp. 1891-1908
-
-
Felczak, K.1
Pankiewicz, K.W.2
-
17
-
-
42049105745
-
Nicotinamide adenine dinucleotide based therapeutics
-
Chen L, Petrelli R, Felczak K, et al. Nicotinamide adenine dinucleotide based therapeutics. Curr Med Chem 2008;15:650-70.
-
(2008)
Curr Med Chem
, vol.15
, pp. 650-670
-
-
Chen, L.1
Petrelli, R.2
Felczak, K.3
-
18
-
-
84860144482
-
The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (b/a)8 barrel enzymes
-
Hedstrom L. The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (b/a)8 barrel enzymes. Crit Rev Biochem Mol Biol 2012;47:250-63.
-
(2012)
Crit Rev Biochem Mol Biol
, vol.47
, pp. 250-263
-
-
Hedstrom, L.1
-
19
-
-
85027923372
-
Virtual and experimental high-throughput screening (HTS) in search of novel inosine 50-monophosphate dehydrogenase II (IMPDH II) inhibitors
-
Dunkern T, Prabhu A, Kharkar PS, et al. Virtual and experimental high-throughput screening (HTS) in search of novel inosine 50-monophosphate dehydrogenase II (IMPDH II) inhibitors. J Comput Aided Mol Des 2012;26:1277-92.
-
(2012)
J Comput Aided Mol des
, vol.26
, pp. 1277-1292
-
-
Dunkern, T.1
Prabhu, A.2
Kharkar, P.S.3
-
20
-
-
39549088916
-
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery
-
Shu Q, Nair V. Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery. Med Res Rev 2008;28:219-32.
-
(2008)
Med Res Rev
, vol.28
, pp. 219-232
-
-
Shu, Q.1
Nair, V.2
-
21
-
-
0035888146
-
Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo 3.1.0 hexane-2,4-diones: Potent inhibitors of human type II inosine 50-monophosphate dehydrogenase
-
Barnes BJ, Izydore RA, Eakin AE, Hall IH. Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo 3.1.0 hexane-2,4-diones: potent inhibitors of human type II inosine 50-monophosphate dehydrogenase. Int J Cancer 2001;94:275-81.
-
(2001)
Int J Cancer
, vol.94
, pp. 275-281
-
-
Barnes, B.J.1
Izydore, R.A.2
Eakin, A.E.3
Hall, I.H.4
-
22
-
-
79952192915
-
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain
-
Felczak K, Chen L, Wilson D, et al. Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain. Bioorg Med Chem 2011;19:1594-605.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 1594-1605
-
-
Felczak, K.1
Chen, L.2
Wilson, D.3
-
23
-
-
30344455618
-
Treating HCV with ribavirin analogues and ribavirin-like molecules purine riboside
-
Gish RG. Treating HCV with ribavirin analogues and ribavirin-like molecules purine riboside. J Antimicrob Chemother 2006;57:8-13.
-
(2006)
J Antimicrob Chemother
, vol.57
, pp. 8-13
-
-
Gish, R.G.1
-
24
-
-
0020663387
-
Effect of several antiviral agents on human lymphocyte functions and marrow progenitor cell proliferation
-
Wingard JR, Hess AD, Stuart RK, et al. Effect of several antiviral agents on human lymphocyte functions and marrow progenitor cell proliferation. Antimicrob Agents Chemother 1983;23:593-7.
-
(1983)
Antimicrob Agents Chemother
, vol.23
, pp. 593-597
-
-
Wingard, J.R.1
Hess, A.D.2
Stuart, R.K.3
-
26
-
-
0032428770
-
Respiratory syncytial virus (RSV) disease and prospects for its control
-
Wyde PR. Respiratory syncytial virus (RSV) disease and prospects for its control. Antiviral Res 1998;39:63-79.
-
(1998)
Antiviral Res
, vol.39
, pp. 63-79
-
-
Wyde, P.R.1
-
27
-
-
0025686065
-
Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase
-
Fernandez-Larson R, Patterson JL. Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase. Mol Pharmacol 1990;36:766-70.
-
(1990)
Mol Pharmacol
, vol.36
, pp. 766-770
-
-
Fernandez-Larson, R.1
Patterson, J.L.2
-
29
-
-
73449130490
-
Mizoribine: A new approach in the treatment of renal disease
-
Kawasaki Y. Mizoribine: a new approach in the treatment of renal disease. Clin Develop Immunol 2009;2009:681482 (1-10).
-
(2009)
Clin Develop Immunol
, vol.2009
, Issue.1-10
, pp. 681482
-
-
Kawasaki, Y.1
-
30
-
-
0034121721
-
The structure of inosine 50-monophosphate dehydrogenase and the design of novel inhibitors
-
Sintchak MD, Nimmesgern E. The structure of inosine 50-monophosphate dehydrogenase and the design of novel inhibitors. Immunopharmacology 2000;47:163-84.
-
(2000)
Immunopharmacology
, vol.47
, pp. 163-184
-
-
Sintchak, M.D.1
Nimmesgern, E.2
-
31
-
-
84875313971
-
Novel inhibitors of inosine monophospate dehydrogenase in patent literature of the last decade
-
Petrelli R, Vita P, Torquati I, et al. Novel inhibitors of inosine monophospate dehydrogenase in patent literature of the last decade. Recent Pat Anticancer Drug Discov 2013;8:103-25.
-
(2013)
Recent Pat Anticancer Drug Discov
, vol.8
, pp. 103-125
-
-
Petrelli, R.1
Vita, P.2
Torquati, I.3
-
32
-
-
67650649489
-
IMP dehydrogenase: Structure, mechanism and inhibition
-
Hedstrom L. IMP dehydrogenase: structure, mechanism and inhibition. Chem Rev 2009;109:2903-28.
-
(2009)
Chem Rev
, vol.109
, pp. 2903-2928
-
-
Hedstrom, L.1
-
33
-
-
77953800819
-
Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis
-
Chen L, Wilson DJ, Xu Y, et al. Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis. J Med Chem 2010;53:4768-78.
-
(2010)
J Med Chem
, vol.53
, pp. 4768-4778
-
-
Chen, L.1
Wilson, D.J.2
Xu, Y.3
-
35
-
-
77953514014
-
The chemistry of mycophenolic acid-synthesis and modifications towards desired biological activity
-
Cholewinski G, Malachowska-Ugarte M, Dzierzbicka K. The chemistry of mycophenolic acid-synthesis and modifications towards desired biological activity. Curr Med Chem 2010;17: 1926-41.
-
(2010)
Curr Med Chem
, vol.17
, pp. 1926-1941
-
-
Cholewinski, G.1
Malachowska-Ugarte, M.2
Dzierzbicka, K.3
-
36
-
-
10244220030
-
Structure-activity relationships for inhibition of inosine monophosphatedehydrogenase by nuclear variants of mycophenolic acid
-
Nelson PH, Carr SF, Devens BH, et al. Structure-activity relationships for inhibition of inosine monophosphatedehydrogenase by nuclear variants of mycophenolic acid. J Med Chem 1996;39: 4181-96.
-
(1996)
J Med Chem
, vol.39
, pp. 4181-4196
-
-
Nelson, P.H.1
Carr, S.F.2
Devens, B.H.3
-
37
-
-
84655169697
-
The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives
-
Yang N, Wang Q, Wang W, et al. The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives. Bioorg Med Chem Lett 2012;22:53-6.
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 53-56
-
-
Yang, N.1
Wang, Q.2
Wang, W.3
-
38
-
-
84864414205
-
Synthesis and biological activity of novel mycophenolic acid conjugates containing nitro-acridine/acridone derivatives
-
Malachowska-Ugarte M, Cholewinski G, Dzierzbicka K, Trzonkowski P. Synthesis and biological activity of novel mycophenolic acid conjugates containing nitro-acridine/acridone derivatives. Eur J Med Chem 2012;54:197-201.
-
(2012)
Eur J Med Chem
, vol.54
, pp. 197-201
-
-
Malachowska-Ugarte, M.1
Cholewinski, G.2
Dzierzbicka, K.3
Trzonkowski, P.4
-
39
-
-
84885333306
-
Synthesis and biological activity of mycophenolic acid-amino acid derivatives
-
Iwaszkiewicz-Grzes D, Cholewinski G, Kot-Wasik A, et al. Synthesis and biological activity of mycophenolic acid-amino acid derivatives. Eur J Med Chem 2013;69:863-71.
-
(2013)
Eur J Med Chem
, vol.69
, pp. 863-871
-
-
Iwaszkiewicz-Grzes, D.1
Cholewinski, G.2
Kot-Wasik, A.3
-
41
-
-
48449098290
-
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase
-
Chen L, Petrelli R, Olesiak M, et al. Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem 2008;16: 7462-9.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 7462-7469
-
-
Chen, L.1
Petrelli, R.2
Olesiak, M.3
-
42
-
-
84882577865
-
Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH
-
Sunohara K, Mitsuhashi S, Shigetomi K, Ubukata M. Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH. Bioorg Med Chem Lett 2013;23:5140-4.
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 5140-5144
-
-
Sunohara, K.1
Mitsuhashi, S.2
Shigetomi, K.3
Ubukata, M.4
-
43
-
-
77953800819
-
Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis
-
Chen L, Wilson DJ, Xu Y, et al. Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis. J Med Chem 2010;53:4768-78.
-
(2010)
J Med Chem
, vol.53
, pp. 4768-4778
-
-
Chen, L.1
Wilson, D.J.2
Xu, Y.3
-
44
-
-
84890820212
-
Synthesis and characterization of an anti-apoptotic immunosuppressive compound for improving the outcome of islet transplantation
-
Wu H, Pagadala J, Yates Ch R, et al. Synthesis and characterization of an anti-apoptotic immunosuppressive compound for improving the outcome of islet transplantation. Bioconjugate Chem 2013;24: 2036-44.
-
(2013)
Bioconjugate Chem
, vol.24
, pp. 2036-2044
-
-
Wu, H.1
Pagadala, J.2
Yates Ch, R.3
-
45
-
-
84859878694
-
Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp
-
Chen Z, Zheng Z, Huang H, et al. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg Med Chem Lett 2012;22:3332-5.
-
(2012)
SOF07. Bioorg Med Chem Lett
, vol.22
, pp. 3332-3335
-
-
Chen, Z.1
Zheng, Z.2
Huang, H.3
-
46
-
-
53249154201
-
Mycophenolic acid analogues with a modified metabolic profile
-
Chen L, Wilson DJ, Labello NP, et al. Mycophenolic acid analogues with a modified metabolic profile. Bioorg Med Chem 2008;16: 9340-5.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 9340-9345
-
-
Chen, L.1
Wilson, D.J.2
Labello, N.P.3
-
47
-
-
2442434461
-
Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid
-
El-Araby ME, Bernacki RJ, Makara GM, et al. Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid. Bioorg Med Chem 2004;12:2867-79.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 2867-2879
-
-
El-Araby, M.E.1
Bernacki, R.J.2
Makara, G.M.3
-
48
-
-
37349017604
-
Dual inhibitors of IMP-dehydrogenase and histone deacetylases for cancer treatment
-
Chen L, Wilson D, Jayaram HN, Pankiewicz KW. Dual inhibitors of IMP-dehydrogenase and histone deacetylases for cancer treatment. J Med Chem 2007;50:6685-91.
-
(2007)
J Med Chem
, vol.50
, pp. 6685-6691
-
-
Chen, L.1
Wilson, D.2
Jayaram, H.N.3
Pankiewicz, K.W.4
-
49
-
-
58149173769
-
Development and manufacture of the inosine monophosphate dehydrogenase inhibitor merimepodid, VX-497
-
Looker AR, Littler BJ, Blythe TA, et al. Development and manufacture of the inosine monophosphate dehydrogenase inhibitor merimepodid, VX-497. Org Process Res Dev 2008;12:666-73.
-
(2008)
Org Process Res Dev
, vol.12
, pp. 666-673
-
-
Looker, A.R.1
Littler, B.J.2
Blythe, T.A.3
-
50
-
-
0035040691
-
VX-497: A novel, selective IMPDH inhibitor and immunosuppressive agent
-
Jain J, Almquist SJ, Shlyakhter D, Harding MW. VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci 2001;90:625-37.
-
(2001)
J Pharm Sci
, vol.90
, pp. 625-637
-
-
Jain, J.1
Almquist, S.J.2
Shlyakhter, D.3
Harding, M.W.4
-
51
-
-
0036748205
-
Preparation of 5-(2-methoxy-4-nitrophenyl)oxazole: A key intermediate for the construction of VX-497
-
Herr RJ, Fairfax DJ, Meckler H, Wilson JD. Preparation of 5-(2-methoxy-4-nitrophenyl)oxazole: a key intermediate for the construction of VX-497. Org Process Res Dev 2002;6:677-81.
-
(2002)
Org Process Res Dev
, vol.6
, pp. 677-681
-
-
Herr, R.J.1
Fairfax, D.J.2
Meckler, H.3
Wilson, J.D.4
-
53
-
-
0037161583
-
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]-amino]-5-oxazolyl]phenyl]-N-methyl-4-morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity
-
Dhar TGM, Shen Z, Guo J, et al. Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]-amino]-5-oxazolyl]phenyl]-N-methyl-4-morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity. J Med Chem 2002;45:2127-30.
-
(2002)
J Med Chem
, vol.45
, pp. 2127-2130
-
-
Dhar, T.G.M.1
Shen, Z.2
Guo, J.3
-
54
-
-
0037071922
-
A modified approach to 2-(N-aryl)-1,3-oxazoles: Application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues
-
Dhar TGM, Guo J, Shen Z, et al. A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues. Org Lett 2002;4:2091-3.
-
(2002)
Org Lett
, vol.4
, pp. 2091-2093
-
-
Dhar, T.G.M.1
Guo, J.2
Shen, Z.3
-
55
-
-
77955466735
-
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure
-
Chen L, Petrelli R, Gao G, et al. Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure. Bioorg Med Chem 2010; 18:5950-64.
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 5950-5964
-
-
Chen, L.1
Petrelli, R.2
Gao, G.3
-
56
-
-
0037328362
-
Novel inhibitors of IMPDH: A highly potent and selective quinolone-based series
-
Watterson SH, Carlsen M, Dhar TGM, et al. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett 2003;13:543-6.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 543-546
-
-
Watterson, S.H.1
Carlsen, M.2
Dhar, T.G.M.3
-
57
-
-
84883172782
-
Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenyl amines
-
Zhong Z-J, Zhang D-J, Peng Z-G, et al. Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenyl amines. Eur J Med Chem 2013;69:32-43.
-
(2013)
Eur J Med Chem
, vol.69
, pp. 32-43
-
-
Zhong, Z.-J.1
Zhang, D.-J.2
Peng, Z.-G.3
-
58
-
-
84861193630
-
The novel 1,2,4-triazole-3-carboxamide and imidazole derivatives of L-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations
-
Wittine K, Stepkowić Babić M, Makuc D, et al. The novel 1,2,4-triazole-3-carboxamide and imidazole derivatives of L-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations. Bioorg Med Chem 2012;20:3675-85.
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 3675-3685
-
-
Wittine, K.1
Stepkowić Babić, M.2
Makuc, D.3
-
59
-
-
82255163308
-
In vitro and in vivo characterization of AS2643361, a novel and highly potent inosine 50-monophosphate dehydrogenase inhibitor
-
Nakanishi T, Kozuki Y, Eikyu Y, et al. In vitro and in vivo characterization of AS2643361, a novel and highly potent inosine 50-monophosphate dehydrogenase inhibitor. Eur J Pharm 2012;674: 58-63.
-
(2012)
Eur J Pharm
, vol.674
, pp. 58-63
-
-
Nakanishi, T.1
Kozuki, Y.2
Eikyu, Y.3
-
60
-
-
34547610513
-
Acridone-based inhibitors of inosine 50-monophosphate dehydrogenase: Discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl) pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)
-
Watterson SH, Chen P, Zhao Y, et al. Acridone-based inhibitors of inosine 50-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl) pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J Med Chem 2007;50:3730-42.
-
(2007)
J Med Chem
, vol.50
, pp. 3730-3742
-
-
Watterson, S.H.1
Chen, P.2
Zhao, Y.3
|