Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 11, 2004, Pages 2867-2879

  El Araby, Moustafa E ^a,c   Bernacki, Ralph J ^b   Makara, Gergely M ^a,d   Pera, Paula J ^b   Anderson, Wayne K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c JOHNSON AND JOHNSON   (United States)

^d NeoGenesis Drug Discovery   (United States)

Author keywords

IMPDH; Mycophenolic acid

Indexed keywords

INDOLE 3 CARBOXAMIDE; INDOLE DERIVATIVE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHINESE HAMSTER; CONTROLLED STUDY; CYCLIZATION; DERIVATIZATION; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HECK REACTION; HUMAN; MITSUNOBU REACTION; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE BINDING SITE; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; CRICETINAE; HUMANS; IMP DEHYDROGENASE; INDOLES; MODELS, MOLECULAR; MYCOPHENOLIC ACID; NAD; STRUCTURE-ACTIVITY RELATIONSHIP;

CRICETINAE; CRICETULUS GRISEUS;

EID: 2442434461     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.048     Document Type: Article

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