Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5140-5144

  Sunohara, Kazuhiro ^a   Mitsuhashi, Shinya ^a   Shigetomi, Kengo ^a   Ubukata, Makoto ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Erythroid differentiation; Histone deacetylase (HDAC); Inosine 5 monophosphate dehydrogenase (IMPDH); Mycophenolic acid; Mycophenolic hydroxamic acid

Indexed keywords

AMIDE; GUANOSINE; HYDROXAMIC ACID; KETONE DERIVATIVE; MYCOPHENOLIC ACID;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL DIFFERENTIATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL;

ERYTHROID DIFFERENTIATION; HISTONE DEACETYLASE (HDAC); INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE (IMPDH); MYCOPHENOLIC ACID; MYCOPHENOLIC HYDROXAMIC ACID;

AMIDES; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; EPOXY COMPOUNDS; HUMANS; IMP DEHYDROGENASE; K562 CELLS; KETONES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84882577865     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.016     Document Type: Article

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