Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]-amino]-5-oxazolyl]phenyl]-N- methyl-4-morpholinea0cetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2127-2130

  Dhar, T G Murali ^a   Shen, Zhongqi ^a   Guo, Junqing ^a   Liu, Chunjian ^a   Watterson, Scott H ^a   Gu, Henry H ^a   Pitts, William J ^a   Fleener, Catherine A ^a   Rouleau, Katherine A ^a   Sherbina, N Z ^a   McIntyre, Kim W ^a   Witmer, Mark R ^a   Tredup, Jeffrey A ^a   Chen, Bang Chi ^a   Zhao, Rulin ^a   Bednarz, Mark S ^a   Cheney, Daniel L ^a   MacMaster, John F ^a   Miller, Laura M ^a   Berry, Karen K ^a   Harper, Timothy W ^a   Barrish, Joel C ^a   Hollenbaugh, Diane L ^a   Iwanowicz, Edwin J ^a   more..

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BMS 337197; CORTICOSTEROID; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; INOSINATE DEHYDROGENASE INHIBITOR; MERIMEPODIB; MIZORIBINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; N [2 [2 [[3 METHOXY 4 (5 OXAZOLYL)PHENYL]AMINO] 5 OXAZOLYL]PHENYL] N METHYL 4 MORPHOLINEACETAMIDE; RIBAVIRIN; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; HEMOLYTIC ANEMIA; HEPATITIS C; HUMAN; NONHUMAN; RAT; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; STRUCTURE ACTIVITY RELATION; TRANSPLANTATION; VIRUS INFECTION;

ANIMALS; ANTIBODY FORMATION; ARTHRITIS, EXPERIMENTAL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMP DEHYDROGENASE; MALE; MICE; MICE, INBRED BALB C; MORPHOLINES; MYCOPHENOLIC ACID; OXAZOLES; RATS; RATS, INBRED LEW; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037161583     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0105777     Document Type: Article

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