Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5950-5964

  Chen, Liqiang ^a   Petrelli, Riccardo ^a,d   Gao, Guangyao ^a   Wilson, Daniel J ^a   McLean, Garrett T ^a   Jayaram, Hiremagalur N ^b   Sham, Yuk Y ^a,c   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Cancer therapy; Cinnamic hydroxamic acid; Drug resistance; Dual inhibitor; Histone deacetylase; Inosine monophosphate dehydrogenase

Indexed keywords

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; ANTINEOPLASTIC AGENT; BELINOSTAT; BMS 337197; CINNAMIC ACID DERIVATIVE; CINNAMIC HYDROXAMIC ACID; ENTINOSTAT; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; INOSINATE DEHYDROGENASE INHIBITOR; MERIMEPODIB; MOCETINOSTAT; MYCOPHENOLIC ACID; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; PANOBINOSTAT; ROMIDEPSIN; SNDX 275; TIAZOFURIN; UNCLASSIFIED DRUG; VORINOSTAT; VX 148;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CROSS LINKING; DRUG DESIGN; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CINNAMATES; DRUG RESISTANCE, NEOPLASM; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IMP DEHYDROGENASE; MODELS, MOLECULAR; NEOPLASMS;

EID: 77955466735     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.081     Document Type: Article

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