Acridone-based inhibitors of inosine 5′-monophosphate dehydrogenase: Discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1- yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Journal of Medicinal Chemistry

Volumn 50, Issue 15, 2007, Pages 3730-3742

  Watterson, Scott H ^a   Chen, Ping ^a   Zhao, Yufen ^a   Gu, Henry H ^a   Dhar, T G Murali ^a   Xiao, Zili ^a   Ballentine, Shelley K ^a   Shen, Zhongqi ^a   Fleener, Catherine A ^a   Rouleau, Katherine A ^a   Obermeier, Mary ^a   Yang, Zheng ^a   McIntyre, Kim W ^a   Shuster, David J ^a   Witmer, Mark ^a   Dambach, Donna ^a   Chao, Sam ^a   Mathur, Arvind ^a   Chen, Bang Chi ^a   Barrish, Joel C ^a   Robl, Jeffrey A ^a   Townsend, Robert ^a   Iwanowicz, Edwin J ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [6 (4 ETHYLPIPERAZIN 1 YL)PYRIDIN 3 YL]PROPAN 2 YL] 2 FLUORO 9 OXO 9,10 DIHYDROACRIDINE 3 CARBOXAMIDE; ACRIDONE DERIVATIVE; BMS 566419; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; LEWIS RAT; NONHUMAN; RAT; RHEUMATOID ARTHRITIS; STRUCTURE ANALYSIS;

ACRIDINES; ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BIOLOGICAL AVAILABILITY; CELL LINE; CELL PROLIFERATION; GASTROINTESTINAL TRACT; HALF-LIFE; HUMANS; IMP DEHYDROGENASE; LEUKOCYTES, MONONUCLEAR; MACACA FASCICULARIS; MALE; PIPERAZINES; RATS; RATS, INBRED LEW; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34547610513     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070299x     Document Type: Article

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