Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3675-3685

  Wittine, Karlo ^a   Stipković Babić, Maja ^a   Makuc, Damjan ^b,c   Plavec, Janez ^b,c   Kraljević Pavelić, Sandra ^d   Sedić, Mirela ^d   Pavelić, Krešimir ^d   Leyssen, Pieter ^e   Neyts, Johan ^e   Balzarini, Jan ^e   Mintas, Mladen ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^c EN FIST Centre of Excellence   (Slovenia)

^d University of Rijeka   (Croatia)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

1,2,4 Triazole; Anti HCV activity; Antitumor activity; Imidazole; IMPDH; l ascorbic acid

Indexed keywords

1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO 1H PYRROL 2 YL) ETHYL] 1H 1,2,4 TRIAZOLE 3 CARBOXYLIC ACID AMIDE; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO 1H PYRROL 2 YL) ETHYL] 1H IMIDAZOLE 4,5 DICARBOXYLIC ACID DIAMIDE; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO 1H PYRROL 2 YL) ETHYL] 1H IMIDAZOLE 4,5 DICARBOXYLIC ACID DIMETHYL ESTER; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) 2 HYDROXY ETHYL] 1H 1,2,4 TRIAZOLE 3 CARBOXYLIC ACID METHYL ESTER; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 1H 1,2,4 TRIAZOLE 3 CARBOXYLIC ACID AMIDE; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 1H 1,2,4 TRIAZOLE 3 CARBOXYLIC ACID DIMETHYL ESTER; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 1H 1,2,4 TRIAZOLE 3 CARBOXYLIC ACID METHYL ESTER; 1 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 1H IMIDAZOLE 4,5 DICARBONITRILE; 1,2,4 TRIAZOLE DERIVATIVE; ASCORBIC ACID; DNA; DOXORUBICIN; FLUOROURACIL; IMIDAZOLE DERIVATIVE; INOSINATE DEHYDROGENASE; PURINE NUCLEOTIDE; RIBAVIRIN; RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FIBROBLAST; HEPATITIS C VIRUS; HUMAN; IC 50; NUCLEOTIDE METABOLISM; RNA SYNTHESIS; T CELL LEUKEMIA; VIRUS REPLICATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ASCORBIC ACID; CELL LINE, TUMOR; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HEPACIVIRUS; HUMANS; IMIDAZOLES; IMP DEHYDROGENASE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; TRIAZOLES; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84861193630     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.054     Document Type: Article

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