-
2
-
-
0024402524
-
Phase 1 and pharmacodynamic study of taxol in refractory acute leukemias
-
Rowinsky EK, Cazenaeva LA, Burke PJ, Karp JE, Tucker RW, Ettinger DS and Donehower RC: Phase 1 and pharmacodynamic study of taxol in refractory acute leukemias. Cancer Res 49: 4640-4647, 1989.
-
(1989)
Cancer Res
, vol.49
, pp. 4640-4647
-
-
Rowinsky, E.K.1
Cazenaeva, L.A.2
Burke, P.J.3
Karp, J.E.4
Tucker, R.W.5
Ettinger, D.S.6
Donehower, R.C.7
-
3
-
-
0021229643
-
Taxol: An antimitotic agent with a new mechanism of action
-
Manfredi JJ and Horowitz SB: Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther 25: 83-125, 1984.
-
(1984)
Pharmacol Ther
, vol.25
, pp. 83-125
-
-
Manfredi, J.J.1
Horowitz, S.B.2
-
5
-
-
0026346104
-
IMP dehydrogenase and GTP as targets in human leukemia treatment
-
Weber G: IMP dehydrogenase and GTP as targets in human leukemia treatment. Adv Exptl Med and Biol 309: 287-292, 1991.
-
(1991)
Adv Exptl Med and Biol
, vol.309
, pp. 287-292
-
-
Weber, G.1
-
6
-
-
0019953349
-
The conversion of 2-ß-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibiting properties
-
Cooney DA, Jayaram HN, Gebeyeu G, Betts CR, Kelley JA, Marquez VE and Johns DG: The conversion of 2-ß-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibiting properties. Biochem Pharmacol 31: 2133-2136, 1982.
-
(1982)
Biochem Pharmacol
, vol.31
, pp. 2133-2136
-
-
Cooney, D.A.1
Jayaram, H.N.2
Gebeyeu, G.3
Betts, C.R.4
Kelley, J.A.5
Marquez, V.E.6
Johns, D.G.7
-
7
-
-
0020450359
-
Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-ß-D-ribofuranosylthiazole-4-carboxamide (NSC 296193)
-
Jayaram HN, Dion RI, Glazer DG, Johns RK, Robins PC and Srivastava PC: Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-ß-D-ribofuranosylthiazole-4-carboxamide (NSC 296193). Biochem Pharmacol 31: 3839-3845, 1982.
-
(1982)
Biochem Pharmacol
, vol.31
, pp. 3839-3845
-
-
Jayaram, H.N.1
Dion, R.I.2
Glazer, D.G.3
Johns, R.K.4
Robins, P.C.5
Srivastava, P.C.6
-
8
-
-
0021368687
-
Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-ß-D-ribofuranosylthiazole-4-carboxamide)
-
Lui MS, Faderan MA, Liepnieks JJ, Natsumeda Y, Olah E, Jayaram HN and Weber G: Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-ß-D-ribofuranosylthiazole-4-carboxamide). J Biol Chem 259: 5078-5082, 1984.
-
(1984)
J Biol Chem
, vol.259
, pp. 5078-5082
-
-
Lui, M.S.1
Faderan, M.A.2
Liepnieks, J.J.3
Natsumeda, Y.4
Olah, E.5
Jayaram, H.N.6
Weber, G.7
-
9
-
-
0020509542
-
Induced maturation of the human promyelocytic leukemia cell line, HL-60, by 2-ß-D-ribofuranosylthiazole-4-carboxamide
-
Lucas DL, Robins RK, Knight RD and Wright DG: Induced maturation of the human promyelocytic leukemia cell line, HL-60, by 2-ß-D-ribofuranosylthiazole-4-carboxamide. Biochem Biophys Res Commun 115: 971-980, 1983.
-
(1983)
Biochem Biophys Res Commun
, vol.115
, pp. 971-980
-
-
Lucas, D.L.1
Robins, R.K.2
Knight, R.D.3
Wright, D.G.4
-
10
-
-
0022575008
-
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase
-
Sokolski JA, Blair OC and Sartorelli AC: Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase. Cancer Res 46: 2314-2319, 1986.
-
(1986)
Cancer Res
, vol.46
, pp. 2314-2319
-
-
Sokolski, J.A.1
Blair, O.C.2
Sartorelli, A.C.3
-
11
-
-
0003922530
-
Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K562 leukemia cells
-
Olah E, Natsumeda Y, Ikegami T, Kote Z, Horanyi M, Szelenyi J, Paulik E, Kremmer T, Hollan SR, Sugar J and Weber G: Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K562 leukemia cells. Proc Natl Acad Sci USA 85: 6533-6537, 1988.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 6533-6537
-
-
Olah, E.1
Natsumeda, Y.2
Ikegami, T.3
Kote, Z.4
Horanyi, M.5
Szelenyi, J.6
Paulik, E.7
Kremmer, T.8
Hollan, S.R.9
Sugar, J.10
Weber, G.11
-
12
-
-
0025806199
-
Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient
-
Weber G, Nagai M, Natsumeda Y, Eble JN, Jayaram HN, Paulik E, Zhen W, Hoffman R and Tricot G: Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient. Cancer Commun 3: 61-66, 1991.
-
(1991)
Cancer Commun
, vol.3
, pp. 61-66
-
-
Weber, G.1
Nagai, M.2
Natsumeda, Y.3
Eble, J.N.4
Jayaram, H.N.5
Paulik, E.6
Zhen, W.7
Hoffman, R.8
Tricot, G.9
-
13
-
-
0025880971
-
Drug-target interaction, only the first step in the commitment to a programmed cell death
-
Dive C and Hickman JA: Drug-target interaction, only the first step in the commitment to a programmed cell death. Br J Cancer 64: 192-196, 1991.
-
(1991)
Br J Cancer
, vol.64
, pp. 192-196
-
-
Dive, C.1
Hickman, J.A.2
-
14
-
-
0018832903
-
Phase and cell cycle specificity of pyrazofurin action
-
Olah E, Lui MS, Tzeng DY and Weber G: Phase and cell cycle specificity of pyrazofurin action. Cancer Res 40: 2869-2875, 1980.
-
(1980)
Cancer Res
, vol.40
, pp. 2869-2875
-
-
Olah, E.1
Lui, M.S.2
Tzeng, D.Y.3
Weber, G.4
-
15
-
-
0024333112
-
"Thymineless" death in androgen-independent prostatic cancer cells
-
Kyprianou N and Isaacs JT: "Thymineless" death in androgen-independent prostatic cancer cells. Biochem Biophys Res Comm 165: 73-81, 1989.
-
(1989)
Biochem Biophys Res Comm
, vol.165
, pp. 73-81
-
-
Kyprianou, N.1
Isaacs, J.T.2
-
16
-
-
0022229184
-
Direct assay method for inosine 5'-monophosphate dehydrogenase activity
-
Ikegami T, Natsumeda Y and Weber G: Direct assay method for inosine 5'-monophosphate dehydrogenase activity. Anal Biochem 150: 155-160, 1985.
-
(1985)
Anal Biochem
, vol.150
, pp. 155-160
-
-
Ikegami, T.1
Natsumeda, Y.2
Weber, G.3
-
17
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
-
Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 62: 156-159, 1987.
-
(1987)
Anal Biochem
, vol.62
, pp. 156-159
-
-
Chomczynski, P.1
Sacchi, N.2
-
19
-
-
0000994406
-
Analysis of combined drug effects: A new look at a very old problem
-
Chou TC and Talalay P: Analysis of combined drug effects: A new look at a very old problem. Trends Pharmacol Sci 4: 450-454, 1983.
-
(1983)
Trends Pharmacol Sci
, vol.4
, pp. 450-454
-
-
Chou, T.C.1
Talalay, P.2
-
21
-
-
0016823448
-
IMP dehydrogenase, an enzyme linked with proliferation and malignancy
-
Jackson RC, Morris HP and Weber G: IMP dehydrogenase, an enzyme linked with proliferation and malignancy. Nature 256: 331-333, 1975.
-
(1975)
Nature
, vol.256
, pp. 331-333
-
-
Jackson, R.C.1
Morris, H.P.2
Weber, G.3
-
22
-
-
0016907181
-
Key enzymes of IMP metabolism: Transformation-and proliferation-linked alterations in gene expression
-
Weber G, Prajda N and Jackson RC: Key enzymes of IMP metabolism: Transformation-and proliferation-linked alterations in gene expression. Advan Enzyme Regul 14: 3-24, 1976.
-
(1976)
Advan Enzyme Regul
, vol.14
, pp. 3-24
-
-
Weber, G.1
Prajda, N.2
Jackson, R.C.3
-
23
-
-
0020955571
-
Biochemical strategy of cancer cells and the design of chemotherapy. G.H.A. Clowes Memorial Lecture
-
Weber G: Biochemical strategy of cancer cells and the design of chemotherapy. G.H.A. Clowes Memorial Lecture. Cancer Res 43: 3466-3492, 1983.
-
(1983)
Cancer Res
, vol.43
, pp. 3466-3492
-
-
Weber, G.1
-
24
-
-
0027217803
-
Taxotere inhibits the proliferation and induces the differentiation of HL-60 and K562 human myeloid leukemia cells in vitro
-
Maurer HR, Eckert K and Bissery MC: Taxotere inhibits the proliferation and induces the differentiation of HL-60 and K562 human myeloid leukemia cells in vitro. Intl J Oncol 3: 161-165, 1993.
-
(1993)
Intl J Oncol
, vol.3
, pp. 161-165
-
-
Maurer, H.R.1
Eckert, K.2
Bissery, M.C.3
-
25
-
-
0027196777
-
Taxol induces internucleosomal fragmentation associated with programmed death in human myeloid leukemia cells
-
Bhalla K, Ibrado AM, Tourkina E, Tang C, Mahoney ME and Huang Y: Taxol induces internucleosomal fragmentation associated with programmed death in human myeloid leukemia cells. Leukemia 7: 563-568, 1993.
-
(1993)
Leukemia
, vol.7
, pp. 563-568
-
-
Bhalla, K.1
Ibrado, A.M.2
Tourkina, E.3
Tang, C.4
Mahoney, M.E.5
Huang, Y.6
-
26
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implication in tissue kinetics
-
Kerr JFR, Wyllie AH and Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implication in tissue kinetics. Br J Cancer 26: 239-257, 1972.
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.R.1
Wyllie, A.H.2
Currie, A.R.3
-
27
-
-
0027219918
-
Signals and genes in the control of cell-cycle progression
-
Muller R, Mumberg D and Lucibello FC: Signals and genes in the control of cell-cycle progression. Biochem Biophys Acta 1155: 151-179, 1993.
-
(1993)
Biochem Biophys Acta
, vol.1155
, pp. 151-179
-
-
Muller, R.1
Mumberg, D.2
Lucibello, F.C.3
-
28
-
-
0025719085
-
Mechanisms and functions of cell death
-
Ellis RE and Horvitz HR: Mechanisms and functions of cell death. Ann Rev Cell Biol 7: 663-698, 1991.
-
(1991)
Ann Rev Cell Biol
, vol.7
, pp. 663-698
-
-
Ellis, R.E.1
Horvitz, H.R.2
-
29
-
-
0025409992
-
Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells
-
Olah E, Kote Zs, Natsumeda Y, Yamaji Y, Jarai G, Lapis E, Financsek I and Weber G: Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells. Cancer Biochem Biophys 1: 107-117, 1990.
-
(1990)
Cancer Biochem Biophys
, vol.1
, pp. 107-117
-
-
Olah, E.1
Kote, Zs.2
Natsumeda, Y.3
Yamaji, Y.4
Jarai, G.5
Lapis, E.6
Financsek, I.7
Weber, G.8
-
30
-
-
0027716040
-
Oncogene patterns in breast and ovarian carcinomas
-
Csokay B, Papp J, Besznyak I, Bosze P, Sarosi Z, Toth J, Zalay Z and Olah E: Oncogene patterns in breast and ovarian carcinomas. Eur J Surg Oncol 19: Suppl. 1, 593-599, 1993.
-
(1993)
Eur J Surg Oncol
, vol.19
, Issue.1 SUPPL.
, pp. 593-599
-
-
Csokay, B.1
Papp, J.2
Besznyak, I.3
Bosze, P.4
Sarosi, Z.5
Toth, J.6
Zalay, Z.7
Olah, E.8
-
31
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC: Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128, 1992.
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.I.1
Wyllie, A.H.2
Gilbert, C.S.3
Littlewood, T.D.4
Land, H.5
Brooks, M.6
Waters, C.M.7
Penn, L.Z.8
Hancock, D.C.9
-
32
-
-
0027656137
-
Synergistic action of taxol and tiazofurin in human ovarian, pancreatic and lung carcinoma cells
-
Taniki T, Prajda N, Monden Y and Weber G: Synergistic action of taxol and tiazofurin in human ovarian, pancreatic and lung carcinoma cells. Cancer Biochem Biophys 13: 295-302, 1993.
-
(1993)
Cancer Biochem Biophys
, vol.13
, pp. 295-302
-
-
Taniki, T.1
Prajda, N.2
Monden, Y.3
Weber, G.4
-
33
-
-
0026442658
-
Inhibition by tiazofurin of inosine 5'-phosphate dehydrogenase activity in extracts of ovarian carcinomas
-
Look KY, Sutton GP, Natsumeda Y, Eble JN, Stehman FB, Ehrlich CE, Olah E, Prajda N, Bosze P, Eckhardt S and Weber G: Inhibition by tiazofurin of inosine 5'-phosphate dehydrogenase activity in extracts of ovarian carcinomas. Gyn Oncol 47: 66-70, 1992.
-
(1992)
Gyn Oncol
, vol.47
, pp. 66-70
-
-
Look, K.Y.1
Sutton, G.P.2
Natsumeda, Y.3
Eble, J.N.4
Stehman, F.B.5
Ehrlich, C.E.6
Olah, E.7
Prajda, N.8
Bosze, P.9
Eckhardt, S.10
Weber, G.11
-
34
-
-
7144220593
-
Taxol-induced apoptosis in MCF-7 breast cancer cells
-
Saunders DA, Lawrence WD, Christensen C, Wappler NL, Malone JM, Malviya VK and Deppe G: Taxol-induced apoptosis in MCF-7 breast cancer cells. Proc Am Assoc Cancer Res 35: 317, 1994.
-
(1994)
Proc Am Assoc Cancer Res
, vol.35
, pp. 317
-
-
Saunders, D.A.1
Lawrence, W.D.2
Christensen, C.3
Wappler, N.L.4
Malone, J.M.5
Malviya, V.K.6
Deppe, G.7
-
35
-
-
0028339458
-
Synergistic action of taxol with tiazofurin and methotrexate in human breast cancer cells: Schedule dependence
-
Yeh YA, Olah E, Wendel JJ, Sledge GW and Weber G: Synergistic action of taxol with tiazofurin and methotrexate in human breast cancer cells: schedule dependence. Life Sci 54: 431-435, 1994.
-
(1994)
Life Sci
, vol.54
, pp. 431-435
-
-
Yeh, Y.A.1
Olah, E.2
Wendel, J.J.3
Sledge, G.W.4
Weber, G.5
-
36
-
-
0029115973
-
Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death
-
Gangcmi RM, Tiso M, Marchetti C, Severi AB and Fabbi M: Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death. Cancer Chemother Pharmacol 36 (5): 385-392, 1995.
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, Issue.5
, pp. 385-392
-
-
Gangcmi, R.M.1
Tiso, M.2
Marchetti, C.3
Severi, A.B.4
Fabbi, M.5
-
38
-
-
0029090720
-
Sequence-dependent antitumor activity of paclitaxel (taxol) and cisplatin in vivo
-
Milross CG, Peters LJ, Hunter NR, Mason KA and Milas L: Sequence-dependent antitumor activity of paclitaxel (taxol) and cisplatin in vivo. Intl J Cancer 62 (5): 599-504, 1995.
-
(1995)
Intl J Cancer
, vol.62
, Issue.5
, pp. 599-1504
-
-
Milross, C.G.1
Peters, L.J.2
Hunter, N.R.3
Mason, K.A.4
Milas, L.5
|