Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7462-7469

  Chen, Liqiang ^a   Petrelli, Riccardo ^a   Olesiak, Magdalena ^a   Wilson, Daniel J ^a   Labello, Nicholas P ^a   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Inosine monophosphate dehydrogenase; Methylenebis(phoshonate); Methylenebis(sulfonamide); Mycophenolic acid; NAD analogues; Nicotinamide adenine dinucleotide

Indexed keywords

ADENINE DERIVATIVE; ADENOSINE 5' METHYLENEBIS (SULFONAMIDE); INOSINATE DEHYDROGENASE; METHYLENEBIS (SULFONAMIDE); MYCOPHENOLIC ADENINE METHYLENEBIS (SULFONAMIDE); MYCOPHENOLIC BIS (SULFONAMIDE); SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE;

ADENINE NUCLEOTIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; IMP DEHYDROGENASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOPHENOLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 48449098290     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.003     Document Type: Article

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