Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 5, 2011, Pages 1594-1605

  Felczak, Krzysztof ^a   Chen, Liqiang ^a   Wilson, Daniel ^a   Williams, Jessica ^a   Vince, Robert ^a   Petrelli, Riccardo ^a   Jayaram, Hiremagalur N ^b   Kusumanchi, Praveen ^b   Kumar, Mohineesh ^b   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Bis(phosphonates); IMPDH; Inhibitor design; Mycophenolic acid; NAD analogues

Indexed keywords

ADENOSINE; ADENOSINE PHOSPHATE; IMATINIB; INOSINATE DEHYDROGENASE INHIBITOR; ISOENZYME; MYCOPHENOLIC 2 ETHYLADENOSIN 5' YL DIFLUOROMETHYLENEBIS(PHOSPHONATE); MYCOPHENOLIC 2 ETHYLADENOSIN 5' YL ETHYLENEBIS(PHOSPHONATE); MYCOPHENOLIC ACID; MYCOPHENOLIC ADENOSIN 5' YL ETHYLENEBIS(PHOSPHONATE); NICOTINAMIDE ADENINE DINUCLEOTIDE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL;

BINDING SITES; CELL PROLIFERATION; DIPHOSPHATES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; IMP DEHYDROGENASE; INHIBITORY CONCENTRATION 50; K562 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 79952192915     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.042     Document Type: Article

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