메뉴 건너뛰기




Volumn 18, Issue 5, 2007, Pages 245-258

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery

Author keywords

Antiviral agents; IMPDH; Inhibitor

Indexed keywords

2 (FLUOROVINYL)INOSINE MONOPHOSPHATE; 2 VINYLINOSINE MONOPHOSPHATE; 3 DEAZAGUANOSINE MONOPHOSPHATE; 5 ETHYNYL 1 BETA DEXTRO RIBOFURANOSYLIMIDAZOLE 4 CARBOXAMIDE; 6 CHLOROPURINE NUCLOESIDE MONOPHOSPHATE; BMS 337197; ENTECAVIR; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; MERIMEPODIB; MIZORIBINE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PM 523; RIBAVIRIN; SELENAZOFURIN; TIAZOFURIN; UNCLASSIFIED DRUG; VX 148;

EID: 36849021519     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020701800501     Document Type: Review
Times cited : (62)

References (91)
  • 1
    • 0028231758 scopus 로고
    • Probing the active site of human IMP dehydrogenase using halogenated purine riboside 5′-monophosphates and covalent modification reagents
    • Antonino LC, Straub K & Wu JC (1994) Probing the active site of human IMP dehydrogenase using halogenated purine riboside 5′-monophosphates and covalent modification reagents. Biochemistry 33:1760-1765.
    • (1994) Biochemistry , vol.33 , pp. 1760-1765
    • Antonino, L.C.1    Straub, K.2    Wu, J.C.3
  • 3
    • 0025880937 scopus 로고
    • Mechanism of the potentiating effect of ribavirin on the activity of 2′,3′- dideoxyinosine against human immunodeficiency virus
    • Balzarini J, Lee CK, Herdewijn P & De Clercq E (1991a) Mechanism of the potentiating effect of ribavirin on the activity of 2′,3′- dideoxyinosine against human immunodeficiency virus. Journal of Biological Chemistry 266:21509-21514.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 21509-21514
    • Balzarini, J.1    Lee, C.K.2    Herdewijn, P.3    De Clercq, E.4
  • 4
    • 0026357107 scopus 로고
    • 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethnyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes
    • Balzarini J, Lee CK, Schols D & De Clercq E (1991b) 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethnyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes. Biochemical and Biophysical Research Communications 178:563-569.
    • (1991) Biochemical and Biophysical Research Communications , vol.178 , pp. 563-569
    • Balzarini, J.1    Lee, C.K.2    Schols, D.3    De Clercq, E.4
  • 7
    • 0014226047 scopus 로고
    • Inactivation of guanosine 5′-phosphate reductase by 6-chloro-, 6-mercapto-, and 2-amino-6-mercapto- 9-β-D-ribofuranosylpurine 5′-phosphates
    • Brox LW & Hampton A (1968) Inactivation of guanosine 5′-phosphate reductase by 6-chloro-, 6-mercapto-, and 2-amino-6-mercapto- 9-β-D-ribofuranosylpurine 5′-phosphates. Biochemistry 7:398-406.
    • (1968) Biochemistry , vol.7 , pp. 398-406
    • Brox, L.W.1    Hampton, A.2
  • 8
    • 19944431381 scopus 로고    scopus 로고
    • Buckley GM, Davies N, Dyke HJ, Gilbert PJ, Hannah DR, Haughan AF, Hunt CA, Pitt WR, Profit RH, Ray NC, Richard MD, Sharpe A, Taylor AJ, Whitworth JM & Williams SC (2005) Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships. Bioorganic & Medicinal Chemistry Letters 15:751-754.
    • Buckley GM, Davies N, Dyke HJ, Gilbert PJ, Hannah DR, Haughan AF, Hunt CA, Pitt WR, Profit RH, Ray NC, Richard MD, Sharpe A, Taylor AJ, Whitworth JM & Williams SC (2005) Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships. Bioorganic & Medicinal Chemistry Letters 15:751-754.
  • 12
    • 0019953349 scopus 로고
    • The conversion of 2-β-D-ribofuranosylthiazole-4- carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties
    • Cooney DA, Jayaram HN, Gebeyehu G, Betts CR, Kelley JA, Marquez VE & Johns DG (1982) The conversion of 2-β-D-ribofuranosylthiazole-4- carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties. Biochemical Pharmacology 31:2133-2136.
    • (1982) Biochemical Pharmacology , vol.31 , pp. 2133-2136
    • Cooney, D.A.1    Jayaram, H.N.2    Gebeyehu, G.3    Betts, C.R.4    Kelley, J.A.5    Marquez, V.E.6    Johns, D.G.7
  • 13
    • 1442285305 scopus 로고    scopus 로고
    • Management and prevention strategies for respiratory syncytial virus (RSV) bronchiolitis in infants and young children: A review of evidence-based practice interventions
    • Cooper AC, Banasiak NC & Allen PJ (2003) Management and prevention strategies for respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a review of evidence-based practice interventions. Pediatric Nursing 29:452-456.
    • (2003) Pediatric Nursing , vol.29 , pp. 452-456
    • Cooper, A.C.1    Banasiak, N.C.2    Allen, P.J.3
  • 16
    • 0028349725 scopus 로고
    • Effects of human T lymphocyte activation on inosine monophosphate dehydrogenase expression
    • Dayton JS, Lindsten T, Thompson CB & Mitchell BS (1994) Effects of human T lymphocyte activation on inosine monophosphate dehydrogenase expression. Journal of Immunology 152:984-991.
    • (1994) Journal of Immunology , vol.152 , pp. 984-991
    • Dayton, J.S.1    Lindsten, T.2    Thompson, C.B.3    Mitchell, B.S.4
  • 17
    • 0035074340 scopus 로고    scopus 로고
    • Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections
    • De Clercq E (2001) Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections. Clinical Microbiology Reviews 14:382-397.
    • (2001) Clinical Microbiology Reviews , vol.14 , pp. 382-397
    • De Clercq, E.1
  • 19
    • 0037161583 scopus 로고    scopus 로고
    • Dhar TGM, Shen Z, Guo J, Liu C, Watterson SH, Gu HH, Pitts WJ, Fleener CA, Rouleau KA, Sherbina NZ, McIntyre KW, Witmer MR, Tredup JA, Chen B-C, Zhao R, Bednarz MS, Cheney DL, MacMaster JF, Miller LM, Berry KK, Harper TW, Barrish JC, Hollenbaugh DL & Iwanowicz EJ (2002) Discovery of N-[2-[2-[[3- Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity. Journal of Medicinal Chemistry 45:2127-2130.
    • Dhar TGM, Shen Z, Guo J, Liu C, Watterson SH, Gu HH, Pitts WJ, Fleener CA, Rouleau KA, Sherbina NZ, McIntyre KW, Witmer MR, Tredup JA, Chen B-C, Zhao R, Bednarz MS, Cheney DL, MacMaster JF, Miller LM, Berry KK, Harper TW, Barrish JC, Hollenbaugh DL & Iwanowicz EJ (2002) Discovery of N-[2-[2-[[3- Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity. Journal of Medicinal Chemistry 45:2127-2130.
  • 20
    • 0033576251 scopus 로고    scopus 로고
    • Species-Specific Inhibition of Inosine 5′-monophosphate dehydrogenase by mycophenolic acid
    • Digits JA & Hedstrom L (1999) Species-Specific Inhibition of Inosine 5′-monophosphate dehydrogenase by mycophenolic acid. Biochemistry 38:15388-15397.
    • (1999) Biochemistry , vol.38 , pp. 15388-15397
    • Digits, J.A.1    Hedstrom, L.2
  • 23
    • 0029982866 scopus 로고    scopus 로고
    • IMP dehydrogenase as a target of antitumor and antiviral chemotherapy
    • Franchetti P, Cappellacci L & Grifantini M (1996) IMP dehydrogenase as a target of antitumor and antiviral chemotherapy. Farmaco 51:457-469.
    • (1996) Farmaco , vol.51 , pp. 457-469
    • Franchetti, P.1    Cappellacci, L.2    Grifantini, M.3
  • 24
    • 0029177012 scopus 로고
    • Glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid
    • Franklin TJ, Jacobs V, Bruneau P & Ple P (1995) Glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid. Advances in Enzyme Regulation 35:91-100.
    • (1995) Advances in Enzyme Regulation , vol.35 , pp. 91-100
    • Franklin, T.J.1    Jacobs, V.2    Bruneau, P.3    Ple, P.4
  • 28
    • 31144445870 scopus 로고    scopus 로고
    • Mechanisms of action of ribavirin against distinct viruses
    • Graci JD & Cameron CE (2006) Mechanisms of action of ribavirin against distinct viruses. Reviews in Medical Virology 16:37-48.
    • (2006) Reviews in Medical Virology , vol.16 , pp. 37-48
    • Graci, J.D.1    Cameron, C.E.2
  • 30
    • 0029050393 scopus 로고
    • Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding
    • Hager PW, Collart FR, Huberman E & Mitchell BS (1995) Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding. Biochemical Pharmacology 49:1323-1329.
    • (1995) Biochemical Pharmacology , vol.49 , pp. 1323-1329
    • Hager, P.W.1    Collart, F.R.2    Huberman, E.3    Mitchell, B.S.4
  • 31
    • 33748519900 scopus 로고    scopus 로고
    • IMP dehydrogenase: Structural schizophrenia and an unusual base
    • Hedstrom L & Gan L (2006) IMP dehydrogenase: structural schizophrenia and an unusual base. Current Opinion in Chemical Biology 10:520-525.
    • (2006) Current Opinion in Chemical Biology , vol.10 , pp. 520-525
    • Hedstrom, L.1    Gan, L.2
  • 32
    • 0025284804 scopus 로고
    • Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poHovirus can be increased only slightly by chemical mutagenesis
    • Holland JJ, Domingo E, de la Torre JC & Steinhauer DA (1990) Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poHovirus can be increased only slightly by chemical mutagenesis. Journal of Virology 64:3960-3962.
    • (1990) Journal of Virology , vol.64 , pp. 3960-3962
    • Holland, J.J.1    Domingo, E.2    de la Torre, J.C.3    Steinhauer, D.A.4
  • 33
    • 0029116425 scopus 로고
    • Polymerase substrate depletion: A novel strategy for inhibiting the replication of the human immunodeficiency virus
    • Ichimura H & Levy JA (1995) Polymerase substrate depletion: a novel strategy for inhibiting the replication of the human immunodeficiency virus. Virology 211:554-560.
    • (1995) Virology , vol.211 , pp. 554-560
    • Ichimura, H.1    Levy, J.A.2
  • 34
    • 0032768502 scopus 로고    scopus 로고
    • Mizoribine and mycophenolate mofetil
    • Ishikawa H (1999) Mizoribine and mycophenolate mofetil. Current Medicinal Chemistry 6:575-597.
    • (1999) Current Medicinal Chemistry , vol.6 , pp. 575-597
    • Ishikawa, H.1
  • 36
    • 0033957303 scopus 로고    scopus 로고
    • Inhibitory effects of EICAR on infectious pancreatic necrosis virus replication
    • Jashes M, Mlynarz G, De Clercq E & Sandino AM (2000) Inhibitory effects of EICAR on infectious pancreatic necrosis virus replication. Antiviral Research 45:9-17.
    • (2000) Antiviral Research , vol.45 , pp. 9-17
    • Jashes, M.1    Mlynarz, G.2    De Clercq, E.3    Sandino, A.M.4
  • 40
    • 0030784762 scopus 로고    scopus 로고
    • The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog
    • Kerr KM & Hedstrom L (1997) The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog. Biochemistry 36:13365-13373.
    • (1997) Biochemistry , vol.36 , pp. 13365-13373
    • Kerr, K.M.1    Hedstrom, L.2
  • 43
    • 20244388105 scopus 로고    scopus 로고
    • Kobashigawa J, Miller L, Renlund D, Mentzer R, Alderman E, Bourge R, Costanzo M, Eisen H, Dureau G, Ratkovec R, Hummel M, Ipe D, Johnson J, Keogh A, Mamelok R, Mancini D, Smart F & L Valantine H (1998) A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators. Transplantation 66:507-515.
    • Kobashigawa J, Miller L, Renlund D, Mentzer R, Alderman E, Bourge R, Costanzo M, Eisen H, Dureau G, Ratkovec R, Hummel M, Ipe D, Johnson J, Keogh A, Mamelok R, Mancini D, Smart F & L Valantine H (1998) A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators. Transplantation 66:507-515.
  • 44
    • 0025961794 scopus 로고
    • Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines
    • Konno Y, Natsumeda Y, Nagai M, Yamaji Y, Ohno S, Suzuki K & Weber G (1991) Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines. Journal of Biological Chemistry 266:506-509.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 506-509
    • Konno, Y.1    Natsumeda, Y.2    Nagai, M.3    Yamaji, Y.4    Ohno, S.5    Suzuki, K.6    Weber, G.7
  • 45
    • 0028030208 scopus 로고
    • Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho- and paramyxoviruses
    • Kosugi Y, Saito Y, Mori S, Watanabe J, Baba M & Shigeta S (1994) Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho- and paramyxoviruses. Antiviral Chemistry & Chemotherapy 5:366-371.
    • (1994) Antiviral Chemistry & Chemotherapy , vol.5 , pp. 366-371
    • Kosugi, Y.1    Saito, Y.2    Mori, S.3    Watanabe, J.4    Baba, M.5    Shigeta, S.6
  • 47
    • 13744258758 scopus 로고    scopus 로고
    • The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase
    • Leyssen P, Balzarini J, De Clercq E & Neyts J (2005) The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. Journal of Virology 79:1943-1947.
    • (2005) Journal of Virology , vol.79 , pp. 1943-1947
    • Leyssen, P.1    Balzarini, J.2    De Clercq, E.3    Neyts, J.4
  • 48
    • 33645102511 scopus 로고    scopus 로고
    • The anti-yellow fever virus activity of ribavirin is independent of error-prone replication
    • Leyssen P, De Clercq E & Neyts J (2006) The anti-yellow fever virus activity of ribavirin is independent of error-prone replication. Molecular Pharmacology 69:1461-1467.
    • (2006) Molecular Pharmacology , vol.69 , pp. 1461-1467
    • Leyssen, P.1    De Clercq, E.2    Neyts, J.3
  • 49
    • 0029670363 scopus 로고    scopus 로고
    • Trapping of an IMP dehydrogenase-substrate covalent intermediate by mycophenolic acid
    • Link JO & Straub K (1996) Trapping of an IMP dehydrogenase-substrate covalent intermediate by mycophenolic acid. Journal of the American Chemical Society 118:2091-2092.
    • (1996) Journal of the American Chemical Society , vol.118 , pp. 2091-2092
    • Link, J.O.1    Straub, K.2
  • 50
    • 0034102651 scopus 로고    scopus 로고
    • Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: A comparison with ribavirin and demonstration of antiviral additivity with alpha interferon
    • Markland W, McQuaid TJ, Jain J & Kwong AD (2000) Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrobial Agents and Chemotherapy 44:859-866.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 859-866
    • Markland, W.1    McQuaid, T.J.2    Jain, J.3    Kwong, A.D.4
  • 52
    • 0023735499 scopus 로고
    • The design, synthesis and antileukemic activity of 5-alkynyl-1-β-D- ribofuranosylimidazole-4-carboxamides
    • Matsuda A, Minakawa N, Sasaki T & Ueda T (1988) The design, synthesis and antileukemic activity of 5-alkynyl-1-β-D- ribofuranosylimidazole-4-carboxamides. Chemical & Pharmaceutical Bulletin 36:2730-2733.
    • (1988) Chemical & Pharmaceutical Bulletin , vol.36 , pp. 2730-2733
    • Matsuda, A.1    Minakawa, N.2    Sasaki, T.3    Ueda, T.4
  • 54
    • 0032775733 scopus 로고    scopus 로고
    • Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: Synthesis and biological activities of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives
    • Minakawa N & Matsuda A (1999) Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: synthesis and biological activities of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives. Current Medicinal Chemistry 6:615-628.
    • (1999) Current Medicinal Chemistry , vol.6 , pp. 615-628
    • Minakawa, N.1    Matsuda, A.2
  • 55
    • 0026083109 scopus 로고
    • Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-β- D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives
    • Minakawa N, Takeda T, Sasaki T, Matsuda A & Ueda T (1991) Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-β- D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives. Journal of Medicinal Chemistry 34:778-786.
    • (1991) Journal of Medicinal Chemistry , vol.34 , pp. 778-786
    • Minakawa, N.1    Takeda, T.2    Sasaki, T.3    Matsuda, A.4    Ueda, T.5
  • 57
    • 0026378294 scopus 로고
    • Selective up-regulation of type II inosine 5′-monophosphate dehydrogenase messenger RNA expression in human leukemias
    • Nagai M, Natsumeda Y, Konno Y, Hoffman R, Irino S & Weber G (1991) Selective up-regulation of type II inosine 5′-monophosphate dehydrogenase messenger RNA expression in human leukemias. Cancer Research 51:3886-3890.
    • (1991) Cancer Research , vol.51 , pp. 3886-3890
    • Nagai, M.1    Natsumeda, Y.2    Konno, Y.3    Hoffman, R.4    Irino, S.5    Weber, G.6
  • 58
    • 0026546968 scopus 로고
    • Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells
    • Nagai M, Natsumeda Y & Weber G (1992) Proliferation-linked regulation of type II IMP dehydrogenase gene in human normal lymphocytes and HL-60 leukemic cells. Cancer Research 52:258-261.
    • (1992) Cancer Research , vol.52 , pp. 258-261
    • Nagai, M.1    Natsumeda, Y.2    Weber, G.3
  • 59
    • 85036958919 scopus 로고    scopus 로고
    • New ribonucleosides with surrogate bases: Synthesis, enzymology, molecular docking studies and antiviral activity
    • Nair V, Ma X, Zhang F, Nishonov M, Shu Q, Sidwell RW, & Kern, ER (2007) New ribonucleosides with surrogate bases: synthesis, enzymology, molecular docking studies and antiviral activity, Antiviral Research 74:A74.
    • (2007) Antiviral Research , vol.74
    • Nair, V.1    Ma, X.2    Zhang, F.3    Nishonov, M.4    Shu, Q.5    Sidwell, R.W.6    Kern, E.R.7
  • 60
    • 36849062671 scopus 로고    scopus 로고
    • Discovery of antiviral agents against RNA viruses: Correlation with inhibition of IMPDH
    • Nair V, Bonsu E, Gupta M, & Story S (2005) Discovery of antiviral agents against RNA viruses: correlation with inhibition of IMPDH Antiviral Research 65:A67.
    • (2005) Antiviral Research , vol.65
    • Nair, V.1    Bonsu, E.2    Gupta, M.3    Story, S.4
  • 62
    • 0037267062 scopus 로고    scopus 로고
    • Synthesis and biological activities of 2-functionalized purine nucleosides
    • Nair V, Bera B & Kern ER (2003) Synthesis and biological activities of 2-functionalized purine nucleosides. Nucleosides, Nucleotides & Nucleic Acids 22:115-127.
    • (2003) Nucleosides, Nucleotides & Nucleic Acids , vol.22 , pp. 115-127
    • Nair, V.1    Bera, B.2    Kern, E.R.3
  • 63
    • 0037293904 scopus 로고    scopus 로고
    • Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5′-monophosphate
    • Nair V & Kamboj RC (2003) Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5′-monophosphate. Bioorganic & Medicinal Chemistry Letters 13:645-647.
    • (2003) Bioorganic & Medicinal Chemistry Letters , vol.13 , pp. 645-647
    • Nair, V.1    Kamboj, R.C.2
  • 64
    • 0026687301 scopus 로고
    • New hypoxanthine nucleosides with RNA antiviral activity
    • Nair V & Ussery MA (1992) New hypoxanthine nucleosides with RNA antiviral activity. Antiviral Research 19:173-178.
    • (1992) Antiviral Research , vol.19 , pp. 173-178
    • Nair, V.1    Ussery, M.A.2
  • 66
    • 0029888393 scopus 로고    scopus 로고
    • Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections
    • Neyts J, Meerbach A, McKenna P & De Clercq E (1996) Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections. Antiviral Research 30:125-132.
    • (1996) Antiviral Research , vol.30 , pp. 125-132
    • Neyts, J.1    Meerbach, A.2    McKenna, P.3    De Clercq, E.4
  • 67
    • 0036836965 scopus 로고    scopus 로고
    • Inhibition of inosine monophosphate dehydrogenase (IMPDH) by the antiviral compound, 2-vinylinosine monophosphate
    • Pal S, Bera B & Nair V (2002) Inhibition of inosine monophosphate dehydrogenase (IMPDH) by the antiviral compound, 2-vinylinosine monophosphate. Bioorganic & Medicinal Chemistry 10:3615-3618.
    • (2002) Bioorganic & Medicinal Chemistry , vol.10 , pp. 3615-3618
    • Pal, S.1    Bera, B.2    Nair, V.3
  • 68
    • 33847039585 scopus 로고    scopus 로고
    • Antiviral activity of tiazofurin and mycophenolic acid against Grapevine Leafroll-associated Virus 3 in Vitis vinifera explants
    • Panattoni A, D'Anna F & Triolo E (2007) Antiviral activity of tiazofurin and mycophenolic acid against Grapevine Leafroll-associated Virus 3 in Vitis vinifera explants. Antiviral Research 73:206-211.
    • (2007) Antiviral Research , vol.73 , pp. 206-211
    • Panattoni, A.1    D'Anna, F.2    Triolo, E.3
  • 69
    • 85037005431 scopus 로고    scopus 로고
    • Pankiewicz KW & Goldstein BM (Editors) Inosine monophosphate dehydrogenase: a major therapeutic target. ACS Symposium Series 839; 2003
    • Pankiewicz KW & Goldstein BM (Editors) Inosine monophosphate dehydrogenase: a major therapeutic target. ACS Symposium Series 839; 2003
  • 71
    • 0037784027 scopus 로고    scopus 로고
    • Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C
    • Pawlotsky J-M (2003) Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C. Antiviral Research 59:1-11.
    • (2003) Antiviral Research , vol.59 , pp. 1-11
    • Pawlotsky, J.-M.1
  • 73
    • 33748604738 scopus 로고    scopus 로고
    • Inosine 5′-monophosphate dehydrogenase inhibitors for the treatment of autoimmune diseases
    • Ratcliffe AJ (2006) Inosine 5′-monophosphate dehydrogenase inhibitors for the treatment of autoimmune diseases. Current Opinion in Drug Discovery & Development 9:595-605.
    • (2006) Current Opinion in Drug Discovery & Development , vol.9 , pp. 595-605
    • Ratcliffe, A.J.1
  • 78
    • 0030756969 scopus 로고    scopus 로고
    • Synergistic anti-influenza virus A (H1N1) activities of PM-523 (polyoxometalate) and ribavirin in vitro and in vivo
    • Shigeta S, Mori S, Watanabe J, Soeda S, Takahashi K & Yamase T (1997) Synergistic anti-influenza virus A (H1N1) activities of PM-523 (polyoxometalate) and ribavirin in vitro and in vivo. Antimicrobial Agents and Chemotherapy 41:1423-1427.
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , pp. 1423-1427
    • Shigeta, S.1    Mori, S.2    Watanabe, J.3    Soeda, S.4    Takahashi, K.5    Yamase, T.6
  • 81
    • 0034121721 scopus 로고    scopus 로고
    • The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors
    • Sintchak MD & Nimmesgern E (2000) The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors. Immunopharmacology 47:163-184.
    • (2000) Immunopharmacology , vol.47 , pp. 163-184
    • Sintchak, M.D.1    Nimmesgern, E.2
  • 82
    • 0035738110 scopus 로고    scopus 로고
    • Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro
    • Smee DF, Bray M & Huggins JW (2001) Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro. Antiviral Chemistry & Chemotherapy 12:327-335.
    • (2001) Antiviral Chemistry & Chemotherapy , vol.12 , pp. 327-335
    • Smee, D.F.1    Bray, M.2    Huggins, J.W.3
  • 83
    • 0034864547 scopus 로고    scopus 로고
    • Ribavirin - current status of a broad spectrum antiviral agent
    • Snell NJC (2001) Ribavirin - current status of a broad spectrum antiviral agent. Expert Opinion on Pharmacotherapy 2:1317-1324.
    • (2001) Expert Opinion on Pharmacotherapy , vol.2 , pp. 1317-1324
    • Snell, N.J.C.1
  • 85
    • 0020663388 scopus 로고
    • Synthesis and antitumor activity of 2-β-D-ribofuranosylselenazole-4-carboxamide and related derivatives
    • Srivastava PC & Robins RK (1983) Synthesis and antitumor activity of 2-β-D-ribofuranosylselenazole-4-carboxamide and related derivatives. Journal of Medicinal Chemistry 26:445-448.
    • (1983) Journal of Medicinal Chemistry , vol.26 , pp. 445-448
    • Srivastava, P.C.1    Robins, R.K.2
  • 86
    • 0017201987 scopus 로고
    • Inhibition of purine nucleotide biosynthesis by 3-deazaguanine, its nucleoside and 5′-nucleotide
    • Streeter DG & Koyama HHP (1976) Inhibition of purine nucleotide biosynthesis by 3-deazaguanine, its nucleoside and 5′-nucleotide. Biochemical Pharmacology 25:2413-2415.
    • (1976) Biochemical Pharmacology , vol.25 , pp. 2413-2415
    • Streeter, D.G.1    Koyama, H.H.P.2
  • 87
    • 0036244310 scopus 로고    scopus 로고
    • Benzamide riboside, a recent inhibitor of inosine 5′-monophosphate dehydrogenase induces transferrin receptors in cancer cells
    • Szekeres T, Sedlak J & Novotny L (2002) Benzamide riboside, a recent inhibitor of inosine 5′-monophosphate dehydrogenase induces transferrin receptors in cancer cells. Current Medicinal Chemistry 9:759-764.
    • (2002) Current Medicinal Chemistry , vol.9 , pp. 759-764
    • Szekeres, T.1    Sedlak, J.2    Novotny, L.3
  • 89
    • 0030047103 scopus 로고    scopus 로고
    • Inactivation of inosine 5′-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide 5′-monophosphate
    • Wang W, Papov W, Minakawa N, Matsuda A, Biemann K & Hedstrom L (1996) Inactivation of inosine 5′-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide 5′-monophosphate. Biochemistry 35:95-101.
    • (1996) Biochemistry , vol.35 , pp. 95-101
    • Wang, W.1    Papov, W.2    Minakawa, N.3    Matsuda, A.4    Biemann, K.5    Hedstrom, L.6
  • 90
    • 8644225553 scopus 로고    scopus 로고
    • Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: Synergistic effect of combination with interferon-α
    • Yanagida K, Baba C & Baba M (2004) Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-α. Antiviral Research 64:195-201.
    • (2004) Antiviral Research , vol.64 , pp. 195-201
    • Yanagida, K.1    Baba, C.2    Baba, M.3
  • 91
    • 33847044794 scopus 로고    scopus 로고
    • Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir
    • Ying C, Colonno R, De Clercq E & Neyts J (2007) Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. Antiviral Research 73:192-196.
    • (2007) Antiviral Research , vol.73 , pp. 192-196
    • Ying, C.1    Colonno, R.2    De Clercq, E.3    Neyts, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.