Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 53, Issue 12, 2010, Pages 4768-4778

  Chen, Liqiang ^a   Wilson, Daniel J ^a   Xu, Yanli ^a   Aldrich, Courtney C ^a   Felczak, Krzysztof ^a   Sham, Yuk Y ^a   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 [2 [[[1 (5' DEOXY ADENOSIN 5' YL) 1H 1,2,3 TRIAZOL 4 YL]METHY]AMINO]ETHYL] 7 HYDROXY 5 METHOXY 4 METHYLISOBENZOFURAN 1(3H) ONE; 6 [4 [4 (ADENOSIN 5' YL)METHYL 1H 1,2,3 TRIAZOL 1 YL] 3 METHYLBUT 2 EN 1 YL] 7 HYDROXY 5 METHOXY 4 METHYLISOBENZOFURAN 1(3H) ONE; 6 [4 [[[1 (5' DEOXY ADENOSIN 5' YL) 1H 1,2,3 TRIAZOL 4 YL]METHY]AMINO] 3 METHYLBUT 2 EN 1 YL] 7 HYDROXY 5 METHOXY 4 METHYLISOBENZOFURAN 1(3H) ONE; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ANALYSIS; ENZYME PURIFICATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ADENINE NUCLEOTIDES; ANTITUBERCULAR AGENTS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMP DEHYDROGENASE; KINETICS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; MYCOPHENOLIC ACID; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 77953800819     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100424m     Document Type: Article

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