Transgenic mouse models for alcohol metabolism, toxicity, and cancer

Advances in Experimental Medicine and Biology

Volumn 815, Issue , 2015, Pages 375-387

  Heit, Claire ^a   Dong, Hongbin ^a   Chen, Ying ^a   Shah, Yatrik M ^b   Thompson, David C ^a   Vasiliou, Vasilis ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1A1; ALDEHYDE DEHYDROGENASE ISOENZYME 1B1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CATALASE; CYTOCHROME P450 2E1; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT; GLUTAMATE CYSTEINE LIGASE MODIFIER SUBUNIT; UNCLASSIFIED DRUG; ACETALDEHYDE; GLUTATHIONE;

ALCOHOL INTOXICATION; ALCOHOL METABOLISM; BREAST CANCER; CARCINOGENESIS; COLORECTAL CANCER; DNA POLYMORPHISM; ENZYME DEFICIENCY; HUMAN; KNOCKOUT MOUSE; LIVER CANCER; MOUSE; MOUSE MODEL; MOUTH CANCER; NONHUMAN; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL; RESPIRATORY TRACT CANCER; TISSUE INJURY; TRANSGENIC MOUSE; ANIMAL; ANIMAL MODEL; CHEMICALLY INDUCED; DEFICIENCY; METABOLISM; NEOPLASM;

ACETALDEHYDE; ANIMALS; ETHANOL; GLUTATHIONE; HUMANS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; NEOPLASMS;

EID: 84937066737     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-09614-8_22     Document Type: Chapter

References (81)

1. Bouchery EE et al (2011) Economic costs of excessive alcohol consumption in the U.S., 2006. Am J Prev Med 41(5):516-524
2. McKillop IH, Schrum LW (2009) Role of alcohol in liver carcinogenesis. Semin Liver Dis 29(2):222-232
3. Seitz HK, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7(8):599-612
4. Visapaa JP et al (2004) Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C *1 allele, possibly due to salivary acetaldehyde. Gut 53(6):871-876
5. Poschl G, Seitz HK (2004) Alcohol and cancer. Alcohol Alcohol 39(3):155-165
6. Boffetta P, Hashibe M (2006) Alcohol and cancer. Lancet Oncol 7(2):149-156
7. Reidy J, McHugh E, Stassen LF (2011) A review of the relationship between alcohol and oral cancer. Surgeon 9(5):278-283
8. Edenberg HJ (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30(1):5-13
9. Deltour L, Foglio MH, Duester G (1999) Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem 274(24):16796-16801
10. Scott DM, Taylor RE (2007) Health-related effects of genetic variations of alcoholmetabolizing enzymes in African Americans. Alcohol Res Health 30(1):18-21
11. Duester G et al (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem Pharmacol 58(3):389-395
12. Lilla C et al (2005) Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case-control study. Br J Cancer 92(11): 2039-2041
13. Lu Y, Cederbaum AI (2008) CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 44(5):723-738
14. Zimatkin SM et al (2006) Enzymatic mechanisms of ethanol oxidation in the brain. Alcohol Clin Exp Res 30(9):1500-1505
15. Vasiliou V et al (2006) CYP2E1 and catalase influence ethanol sensitivity in the central nervous system. Pharmacogenet Genomics 16(1):51-58
16. Millonig G et al (2011) Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions. Int J Cancer 128(3): 533-540
17. Wang Y et al (2009) Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology 50(2):453-461
18. Trafalis DT et al (2010) CYP2E1 and risk of chemically mediated cancers. Expert Opin Drug Metab Toxicol 6(3):307-319
19. Druesne-Pecollo N et al (2009) Alcohol and genetic polymorphisms: effect on risk of alcoholrelated cancer. Lancet Oncol 10(2):173-180
20. Morita M et al (2009) Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev 18(1):235-241
21. Goth LT, Nagy T (2012) Acatalasemia and diabetes mellitus. Arch Biochem Biophys 525(2):195-200
22. Goth L, Rass P, Pay A (2004) Catalase enzyme mutations and their association with diseases. Mol Diagn 8(3):141-149
23. Seitz HK et al (1990) Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology 98(2):406-413
24. Chen Y et al (2011) Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochem Biophys Res Commun 405(2):173-179
25. Husemoen LL et al (2008) The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. Alcohol Clin Exp Res 32(11): 1984-1991
26. Linneberg A et al (2010) Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clin Exp Allergy 40(1):123-130
27. Little RG 2nd, Petersen DR (1983) Subcellular distribution and kinetic parameters of HS mouse liver aldehyde dehydrogenase. Comp Biochem Physiol C 74(2):271-279
28. Bond SL, Wigle MR, Singh SM (1991) Acetaldehyde dehydrogenase (Ahd-2)-associated DNA polymorphisms in mouse strains with variable ethanol preferences. Alcohol Clin Exp Res 15(2):304-307
29. Eriksson CJ (2001) The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 25(5 Suppl ISBRA):15S-32S
30. Yokoyama A et al (2012) Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men. Int J Cancer 130(12):2949-2960
31. Yokoyama A et al (2011) p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia. Cancer Lett 308(1):112-117
32. Yukawa Y et al (2012) Combination of ADH1B *2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics. Cancer Sci 103(9): 1651-1655
33. Arranz S et al (2012) Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients 4(7):759-781
34. Tanaka T (2009) Colorectal carcinogenesis: review of human and experimental animal studies. J Carcinog 8:5
35. Altamirano J, Bataller R (2011) Alcoholic liver disease: pathogenesis and new targets for therapy. Nat Rev Gastroenterol Hepatol 8(9):491-501
36. Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141(5):1572-1585
37. Albano E (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29(1-2):9-16
38. Bergendi L et al (1999) Chemistry, physiology and pathology of free radicals. Life Sci 65(18-19):1865-1874
39. Meister A (1982) Metabolism and function of glutathione: an overview. Biochem Soc Trans 10(2):78-79
40. Kretzschmar M (1996) Regulation of hepatic glutathione metabolism and its role in hepatotoxicity. Exp Toxicol Pathol 48(5):439-446
41. Meister A (1988) Glutathione metabolism and its selective modification. J Biol Chem 263(33):17205-17208
42. Dalton TP et al (2004) Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radic Biol Med 37(10):1511-1526
43. Chen Y et al (2005) Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels. J Biol Chem 280(40):33766-33774
44. Lu SC (1999) Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 13(10):1169-1183
45. Meister A (1995) Glutathione metabolism. Methods Enzymol 251:3-7
46. Wu D, Cederbaum AI (2009) Oxidative stress and alcoholic liver disease. Semin Liver Dis 29(2):141-154
47. Molotkov A et al (2002) Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. J Biol Chem 277(16):13804-13811
48. Haseba T, Ohno Y (2010) A new view of alcohol metabolism and alcoholism-role of the high-Km Class III alcohol dehydrogenase (ADH3). Int J Environ Res Public Health 7(3): 1076-1092
49. Ho YS et al (2004) Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol Chem 279(31):32804-32812
50. Lee SS et al (1996) Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271(20):12063-12067
51. Valentine JL et al (1996) Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. Toxicol Appl Pharmacol 141(1):205-213
52. Wong FW, Chan WY, Lee SS (1998) Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol 153(1):109-118
53. Wang X et al (2013) Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1alpha in vivo. Free Radic Biol Med 63:175-186
54. Lu Y et al (2008) Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47(5):1483-1494
55. Isse T et al (2002) Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12(8):621-626
56. Yu HS et al (2009) Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. Toxicol Mech Methods 19(9):535-540
57. Kiyoshi A et al (2009) Ethanol metabolism in ALDH2 knockout mice-blood acetate levels. Leg Med (Tokyo) 11(Suppl 1):S413-S415
58. Isse T et al (2005) Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin Exp Res 29(11):1959-1964
59. Oyama T et al (2007) A pilot study on subacute ethanol treatment of ALDH2 KO mice. J Toxicol Sci 32(4):421-428
60. Isse T et al (2005) Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality. J Toxicol Sci 30(4):315-328
61. Oyama T et al (2007) Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice. Front Biosci 12:1927-1934
62. Kunugita N et al (2008) Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde. J Toxicol Sci 33(1): 31-36
63. Matsumoto A et al (2007) Single-dose ethanol administration downregulates expression of cytochrome p450 2E1 mRNA in aldehyde dehydrogenase 2 knockout mice. Alcohol 41(8): 587-589
64. Matsumoto A et al (2007) Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver. Alcohol 41(1):57-59
65. Jamal M et al (2013) Ethanol-and acetaldehyde-induced cholinergic imbalance in the hippocampus of Aldh2-knockout mice does not affect nerve growth factor or brain-derived neurotrophic factor. Brain Res 1539:41-47
66. Ma H et al (2010) Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J Mol Cell Cardiol 49(2):322-329
67. Shimizu Y et al (2011) Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice. Bone 48(5):1075-1086
68. Nagayoshi H et al (2009) Increased formation of gastric N(2)-ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. Mutat Res 673(1):74-77
69. Matsumoto A et al (2008) Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenet Genomics 18(10):847-852
70. Kim YD et al (2007) Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice. J Occup Health 49(5):363-369
71. Matsuda T et al (2007) Increased formation of hepatic N2-ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol. Carcinogenesis 28(11):2363-2366
72. Skarnes WC et al (2011) A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474(7351):337-342
73. Stagos D et al (2010) Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metab Dispos 38(10): 1679-1687
74. Fan X et al (2003) Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol 23(13): 4637-4648
75. Lassen N et al (2007) Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice. J Biol Chem 282(35):25668-25676
76. Shi ZZ et al (2000) Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A 97(10):5101-5106
77. Chen Y et al (2007) Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology 45(5):1118-1128
78. Chen Y et al (2010) Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclcknockout mice, providing a model for hepatic cirrhosis. J Hepatol 53(6):1085-1094
79. Yang Y et al (2002) Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J Biol Chem 277(51):49446-49452
80. McConnachie LA et al (2007) Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice. Toxicol Sci 99(2): 628-636
81. Chen Y et al (2012) Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. Chem Res Toxicol 25(1):94-100