Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality

Journal of Toxicological Sciences

Volumn 30, Issue 4, 2005, Pages 315-328

  Isse, Toyohi ^a   Oyama, Tsunehiro ^a   Matsuno, Koji ^b   Uchiyama, Iwao ^c   Kawamoto, Toshihiro ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Acetaldehyde; Aldehyde dehydrogenase 2; Genetic polymorphisms; Pharmacokinetics toxicokinetics; Transgenic models knockouts

Indexed keywords

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY POSTURE; BRADYPNEA; BREATHING DISORDER; COMA; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYANOSIS; DEATH; DYSPNEA; ENZYME ACTIVITY; FEMALE; FLUSHING; GAIT DISORDER; HYPOTHERMIA; LATENT PERIOD; LD 50; LETHALITY; MALE; MOUSE; NONHUMAN; REFLEX; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; TRANSGENIC MOUSE; WHEEZING; WILD TYPE;

ANIMALIA; MUS MUSCULUS;

EID: 30744441657     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.30.315     Document Type: Article

References (25)

1. Brein, J.F. and Loomis, C.W. (1983) : Pharmacology of acetaldehyde. Can. J. Physiol. Pharm., 61, 1-22.
2. Dandre, F., Cassaigne, A. and Iron, A. (1995) : The frequency of the mitochondrial aldehyde dehydrogenase 12 (atypical) allele in Caucasian, Oriental and African black populations determined by the restriction profile of PCR-amplified DNA. Mol. Cell Probe., 9, 189-193.
3. Davis, V.E. and Walsh, M.J. (1970) : Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction. Science, 167, 1005-1007.
4. Downes, J.E. and Holmes, R.S. (1993) : Purification and properties of murine corneal aldehyde dehydrogenase. Biochem. Mol. Biol. Int., 30, 525-535.
5. Eriksson, C.J. (1977) : Acetaldehyde metabolism in vivo during ethanol oxidation. Adv. Exp. Med. Biol., 85A, 319-341.
6. Gehring, P.J, Watanabe, P.G. and Blau, G.E. (1976) : Pharmacokinetic studies in evaluation of the toxicological and environmental hazard of chemicals. In Advances in Modern Toxicology (Mehlman, M.A., Shaprio, R.E. and Blumenthal, H., eds.), Vol.1, Part 1., pp. 195-270, Hemisphere Publishing Corporation, Washington.
7. Ginsberg, G., Smolenski, S., Hattis, D. and Sonawane, B. (2002) : Population distribution of acetaldehyde dehydrogense-2 genetic polymorphism: implications for risk assessment. Regul. Toxicol. Pharm., 36, 297-309.
8. Goedde, H.W., Agarwal, D.P., Fritze, G., Meier-Tackmann, D., Singh, S., Beckmann, G., Bhatia, K., Chen, L.Z., Fang, B., Lisker, R., Paik, Y.K., Rothhammer, F., Saha, N., Segal, B., Srivatavall, L.M. and Czeize, A. (1992) : Distribution of ADH2 and ALDH2 genotypes in different populations. Hum. Genet., 188, 344-346.
9. IPCS (The international Programme on Chemical Safety). (1995) : Environmental health Criteria No.167 Acetaldehyde., pp. 1-129, World Health Organization, Geneva.
10. Isse, T., Oyama, T., Kitagawa, K., Matsuno, K., Matsumoto, A., Yoshida, A., Nakayama, K., Nakayama, K. and Kawamoto, T. (2002) : Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics, 12, 621-626.
11. Isse, T., Matsuno, K., Oyama, T., Kitagawa, K. and Kawamoto, T. (2005) : Aldehyde Dehydrogenase 2 Gene Targeting Mouse Lacking Enzyme Activity Shows High Acetaldehyde Level in Blood, Brain, and Liver after Ethanol Gavages. Alcohol. Clin. Exp. Res., 29, 1959-1964.
12. Kenney, W.C. (1982) : Acetaldehyde adducts of phospholipids. Alcohol. Clin. Exp. Res., 6, 412-416.
13. Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T., Okamoto, K., Yoshida, A., Nakayama, K. and Nakayama, K. (2000) : Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; In vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett., 476, 306-311.
14. Matsuo, K., Hamajima, N., Shinoda, M., Hatooka, S., Inoue, M., Takezaki, T. and Tajima, K. (2001) : Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. Carcinogenesis, 22, 913-916.
15. Mizoi, Y., Yamamoto, K., Ueno, Y., Fukunaga, T. and Harada, S. (1994) : Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol, 29, 707-710.
16. Noori, P. and Hou, S.M. (2001) : Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers. Carcinogenesis, 22, 1825-1830.
17. Novoradovsky, A., Tsai, S.J., Goldfarb, L., Peterson, R., Long, J.C. and Goldman, D. (1995) : Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles. Alcohol Clin. Exp. Res., 19, 1105-1110.
18. Oshea, K.S. and Kaufman, M.H. (1979) : The teratogenic effect of acetaldehyde: Implications for the fetal alcohol syndrome. J. Anat., 128, 65-76.
19. Skog, E. (1950) : A toxicological investigation of lower aliphatic aldehydes. I. Toxicity of fomaldehyde, acetaldehyde, propionaldehyde, butyraldehyde; as well as of acrolein and crotonaldehyde. Acta Pharmacol. Tox., 6, 299-318.
20. Sjoquist, B., Liljequist, S. and Engel, J. (1982) : Increased salsolinol levels in rat striatum and limbic forebrain following chronic ethanol treatment. J. Neurochem., 39, 259-262.
21. Tuma, D.J., Hoffman, T. and Sorrell, M.F. (1991) : The chemistry of acetaldehyde-protein adducts. Alcohol Alcohol, 1 (Suppl.), 271-276.
22. Truitt, E.B.Jr. and Walsh, M.J. (1971) : The role of acetaldehyde in the action of ethanol. In The Biology of AlcoholismVol. 1, Biochemistry, 1st ed. (Kissin, B. and Belgeiter, I., eds.), pp. 161-195, Plenum Press, New York.
23. Weiner, H., Wei, B. and Zhou, J. (2001) : Subunit communication in tetrameric class 2 human liver aldehyde dehydrogenase as the basis for half-of-the-site reactivity and the dominance of the oriental subunit in a heterotetramer. Chem. Biol. Interact., 130-132, 47-56.
24. Wolff, P.H. (1972) : Ethnic differences in alcohol sensitivity. Science, 175, 449-450.
25. Yoshida, A., Huang, I. Y. and Ikawa, M. (1984) : Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc. Natl. Acad. Sci. USA, 81, 258-261.