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Volumn 48, Issue 5, 1996, Pages 439-446

Regulation of hepatic glutathione metabolism and its role in hepatotoxicity

Author keywords

drug metabolism; hepatic glutathione system; hepatotoxicity; xenobiotics

Indexed keywords

GLUTATHIONE; XENOBIOTIC AGENT;

EID: 0029841209     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(96)80054-6     Document Type: Article
Times cited : (88)

References (85)
  • 1
    • 0021080230 scopus 로고
    • Plasma glutathione and glutathione disulfide in the rat: Regulation and response to oxidative stress
    • JD Adams BH Lauterburg JR Mitchell Plasma glutathione and glutathione disulfide in the rat: Regulation and response to oxidative stress J Pharmacol Exp Ther 227 1983 749 754
    • (1983) J Pharmacol Exp Ther , vol.227 , pp. 749-754
    • Adams, JD1    Lauterburg, BH2    Mitchell, JR3
  • 2
    • 0022493791 scopus 로고
    • Mechanisms of inhibition of glutathione efflux by methionine from isolated rat hepatocytes
    • TY Aw M Ookhtens N Kaplowitz Mechanisms of inhibition of glutathione efflux by methionine from isolated rat hepatocytes Am J Physiol 251 1986 G354 G361
    • (1986) Am J Physiol , vol.251 , pp. G354-G361
    • Aw, TY1    Ookhtens, M2    Kaplowitz, N3
  • 3
    • 84912813241 scopus 로고
    • Modulation of hepatic glutathione efflux and bile flow by changes in tight junctional permeability
    • N Ballatori AT Truong Modulation of hepatic glutathione efflux and bile flow by changes in tight junctional permeability Hepatology 10 1989 725
    • (1989) Hepatology , vol.10 , pp. 725
    • Ballatori, N1    Truong, AT2
  • 4
    • 0017873558 scopus 로고
    • Reduced and oxidized glutathione efflux from liver
    • GM Bartoli H Sies Reduced and oxidized glutathione efflux from liver FEBS lett. 86 1978 89 91
    • (1978) FEBS lett. , vol.86 , pp. 89-91
    • Bartoli, GM1    Sies, H2
  • 5
    • 0019165593 scopus 로고
    • Involvement of cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes
    • PW Beatty DJ Reed Involvement of cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes Arch Biochem Biophys 204 1980 80 87
    • (1980) Arch Biochem Biophys , vol.204 , pp. 80-87
    • Beatty, PW1    Reed, DJ2
  • 6
    • 0024561369 scopus 로고
    • The glutathione S-transferases: an update
    • TD Boyer The glutathione S-transferases: an update Hepatology 9 1989 486 496
    • (1989) Hepatology , vol.9 , pp. 486-496
    • Boyer, TD1
  • 7
    • 0020624295 scopus 로고
    • Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide
    • R Brigelius C Muckel TPM Akerboom H Sies Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide Biochem Pharmacol 32 1983 2529 2534
    • (1983) Biochem Pharmacol , vol.32 , pp. 2529-2534
    • Brigelius, R1    Muckel, C2    Akerboom, TPM3    Sies, H4
  • 8
    • 0024512008 scopus 로고
    • Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration
    • JM Burgunder A Varriale BH Lauterburg Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration Eur J Clin Pharmac 36 1989 127 131
    • (1989) Eur J Clin Pharmac , vol.36 , pp. 127-131
    • Burgunder, JM1    Varriale, A2    Lauterburg, BH3
  • 9
    • 0020686355 scopus 로고
    • Biochemistry of sulfur-containing amino-acids
    • AJL Cooper Biochemistry of sulfur-containing amino-acids Ann Rev Biochem 52 1983 187 222
    • (1983) Ann Rev Biochem , vol.52 , pp. 187-222
    • Cooper, AJL1
  • 10
    • 0016138336 scopus 로고
    • Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen
    • DC Davis WZ Potter DJ Jollow JR Mitchell Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen Life Sci 14 1974 2099 2109
    • (1974) Life Sci , vol.14 , pp. 2099-2109
    • Davis, DC1    Potter, WZ2    Jollow, DJ3    Mitchell, JR4
  • 11
    • 0026387907 scopus 로고
    • Glutathione metabolism and its role in hepatotoxicity
    • LD De Leve N Kaplowitz Glutathione metabolism and its role in hepatotoxicity Pharmac Ther 52 1991 287 305
    • (1991) Pharmac Ther , vol.52 , pp. 287-305
    • De Leve, LD1    Kaplowitz, N2
  • 14
    • 0021345735 scopus 로고
    • Oxidation of glutathione during hydroperoxide metabolism. A study using isolated hepatocytes and glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosourea
    • L Eklöw P Moldeus S Orrenius Oxidation of glutathione during hydroperoxide metabolism. A study using isolated hepatocytes and glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosourea Eur J Biochem 138 1984 459 463
    • (1984) Eur J Biochem , vol.138 , pp. 459-463
    • Eklöw, L1    Moldeus, P2    Orrenius, S3
  • 15
    • 0023809525 scopus 로고
    • Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes
    • JC Fernandez-Checa C Ren TY Aw Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes Am J Physiol 255 1988 G403 G408
    • (1988) Am J Physiol , vol.255 , pp. G403-G408
    • Fernandez-Checa, JC1    Ren, C2    Aw, TY3
  • 16
    • 0021761430 scopus 로고
    • Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine
    • JD Finkelstein JJ Martin Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine Biochem Biophys Res Commun 118 1984 14 19
    • (1984) Biochem Biophys Res Commun , vol.118 , pp. 14-19
    • Finkelstein, JD1    Martin, JJ2
  • 17
    • 0024327131 scopus 로고
    • Metabolic changes in glutathione and metallothionein in newborn rat liver
    • KR Gallant MG Cherian Metabolic changes in glutathione and metallothionein in newborn rat liver J Pharmacol Exp Ther 249 1989 631 637
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 631-637
    • Gallant, KR1    Cherian, MG2
  • 18
    • 0022645201 scopus 로고
    • Role of glutathione turnover in drug sulfatation: Different effects of diethylmaleate and buthionine sulfoximine on the pharmacokinetics of acetaminophen in the rat
    • RE Galinsky Role of glutathione turnover in drug sulfatation: Different effects of diethylmaleate and buthionine sulfoximine on the pharmacokinetics of acetaminophen in the rat J Pharmacol Exp Ther 236 1986 133 139
    • (1986) J Pharmacol Exp Ther , vol.236 , pp. 133-139
    • Galinsky, RE1
  • 19
    • 0345568861 scopus 로고
    • Biological disulfides: The third messenger?
    • HF Gilbert Biological disulfides: The third messenger? J Biol Chem 257 1982 1550 1555
    • (1982) J Biol Chem , vol.257 , pp. 1550-1555
    • Gilbert, HF1
  • 20
    • 0021284165 scopus 로고
    • Redox control of enzyme activities by thiol/disulfide exchange
    • HF Gilbert Redox control of enzyme activities by thiol/disulfide exchange Meth Enzymol 107 1984 330 351
    • (1984) Meth Enzymol , vol.107 , pp. 330-351
    • Gilbert, HF1
  • 21
    • 0019765119 scopus 로고
    • Depletion of glutathione by inhibition of biosynthesis
    • OW Griffith Depletion of glutathione by inhibition of biosynthesis Meth Enzymol 77 1981 59 63
    • (1981) Meth Enzymol , vol.77 , pp. 59-63
    • Griffith, OW1
  • 22
    • 0018666729 scopus 로고
    • Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
    • OW Griffith A Meister Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J Biol Chem 254 1979 7558 7560
    • (1979) J Biol Chem , vol.254 , pp. 7558-7560
    • Griffith, OW1    Meister, A2
  • 23
    • 0345654274 scopus 로고
    • Glutathione: Interorgan translocation, turnover and metabolism
    • OW Griffith A Meister Glutathione: Interorgan translocation, turnover and metabolism Proc Natl Acad Sci USA 76 1979 5606 5610
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 5606-5610
    • Griffith, OW1    Meister, A2
  • 24
    • 0001547757 scopus 로고
    • Origin and turnover of mitochondrial glutathione
    • OW Griffith A Meister Origin and turnover of mitochondrial glutathione Proc Natl Acad Sci USA 82 1985 4668 4672
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 4668-4672
    • Griffith, OW1    Meister, A2
  • 25
    • 0023229374 scopus 로고
    • Transepithelial transport of glutathione in vascularly perfused small intestine of rat
    • TM Hagen DP Jones Transepithelial transport of glutathione in vascularly perfused small intestine of rat Am J Physiol 252 1987 G607 G613
    • (1987) Am J Physiol , vol.252 , pp. G607-G613
    • Hagen, TM1    Jones, DP2
  • 26
    • 0022647615 scopus 로고
    • Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity
    • GA Hazelton JJ Hjelle CD Klaassen Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity J Pharmacol Exp Ther 237 1986 341 349
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 341-349
    • Hazelton, GA1    Hjelle, JJ2    Klaassen, CD3
  • 27
    • 0021998639 scopus 로고
    • γ-glutamyl transpeptidase — its role in hepatocarcinogenesis
    • MH Hanigan HC Pitot γ-glutamyl transpeptidase — its role in hepatocarcinogenesis Carcinogenesis 6 1985 165 172
    • (1985) Carcinogenesis , vol.6 , pp. 165-172
    • Hanigan, MH1    Pitot, HC2
  • 28
    • 0022369656 scopus 로고
    • Reevaluation of protein-bound glutathione in rat liver
    • T Higashi M Furukawa K Hikita Reevaluation of protein-bound glutathione in rat liver J Biochem 98 1985 1661 1667
    • (1985) J Biochem , vol.98 , pp. 1661-1667
    • Higashi, T1    Furukawa, M2    Hikita, K3
  • 29
    • 0021342178 scopus 로고
    • Glutathione transport across hepatocyte plasma membranes. Analysis using isolated rat-liver sinusoidal-membrane vesicles
    • M Inoue R Kinne T Tran IM Arias Glutathione transport across hepatocyte plasma membranes. Analysis using isolated rat-liver sinusoidal-membrane vesicles Eur J Biochem 138 1984 491 495
    • (1984) Eur J Biochem , vol.138 , pp. 491-495
    • Inoue, M1    Kinne, R2    Tran, T3    Arias, IM4
  • 30
    • 0006388128 scopus 로고
    • Regulation of redox states of plasma proteins by metabolism and transport of glutathione and related compounds
    • M Inoue Y Saito E Hirata Regulation of redox states of plasma proteins by metabolism and transport of glutathione and related compounds J Prot Chem 6 1987 207 225
    • (1987) J Prot Chem , vol.6 , pp. 207-225
    • Inoue, M1    Saito, Y2    Hirata, E3
  • 31
    • 0016151122 scopus 로고
    • Brombenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite
    • DJ Jollow JR Mitchell N Zampaglione JR Gillette Brombenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite Pharmacology 11 1974 151 169
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, DJ1    Mitchell, JR2    Zampaglione, N3    Gillette, JR4
  • 32
    • 0025960038 scopus 로고
    • Lung uptake of liposomeentrapped glutathione after intratracheal administration
    • M Jurima-Romet PN Shek Lung uptake of liposomeentrapped glutathione after intratracheal administration J Pharm Pharmacol 43 1991 6 10
    • (1991) J Pharm Pharmacol , vol.43 , pp. 6-10
    • Jurima-Romet, M1    Shek, PN2
  • 33
    • 0020701721 scopus 로고
    • Factors of influencing the efflux of hepatic glutathione into bile in rats
    • N Kaplowitz D Eberle J Petrini Factors of influencing the efflux of hepatic glutathione into bile in rats J Pharm Exp Ther 224 1983 141 147
    • (1983) J Pharm Exp Ther , vol.224 , pp. 141-147
    • Kaplowitz, N1    Eberle, D2    Petrini, J3
  • 35
    • 0023687437 scopus 로고
    • Glutathione replenishment capacity is lower in isolated perivenous than in peripheral hepatocytes
    • Y Kera KE Penttilä KO Lindros Glutathione replenishment capacity is lower in isolated perivenous than in peripheral hepatocytes Biochem J 254 1988 411 417
    • (1988) Biochem J , vol.254 , pp. 411-417
    • Kera, Y1    Penttilä, KE2    Lindros, KO3
  • 36
    • 0023006986 scopus 로고
    • Detoxication reactions of glutathione and glutathione transferases
    • B Ketterer Detoxication reactions of glutathione and glutathione transferases Xenobiotics 16 1986 957 973
    • (1986) Xenobiotics , vol.16 , pp. 957-973
    • Ketterer, B1
  • 37
    • 0022602957 scopus 로고
    • Functional hepatocellular heterogeneity determined by the hepatotoxins allyl alcohol and bromobenzene in immature and adult Fischer 344 rats
    • W Klinger T Devereux R Maronpot J Fouts Functional hepatocellular heterogeneity determined by the hepatotoxins allyl alcohol and bromobenzene in immature and adult Fischer 344 rats Toxicol Appl Pharmacol 83 1986 108 114
    • (1986) Toxicol Appl Pharmacol , vol.83 , pp. 108-114
    • Klinger, W1    Devereux, T2    Maronpot, R3    Fouts, J4
  • 38
    • 0024491098 scopus 로고
    • Gamma-glutamytranspeptidase in liver homogenates of rats of different ages: enzyme kinetics and age course of Km and Vmax
    • max Z Versuchstierkd 32 1989 41 47
    • (1989) Z Versuchstierkd , vol.32 , pp. 41-47
    • Kretzschmar, M1    Klinger, W2
  • 39
    • 0027467817 scopus 로고
    • Aging, training and exercise. A review of effects on plasma glutathione and lipid peroxides
    • M Kretzschmar D Müller Aging, training and exercise. A review of effects on plasma glutathione and lipid peroxides Sports Med 15 1993 196 209
    • (1993) Sports Med , vol.15 , pp. 196-209
    • Kretzschmar, M1    Müller, D2
  • 40
    • 0024350658 scopus 로고
    • Glutathione synthesis and export in experimental liver cirrhosis induced by thioacetamide: Relations to ultrastructural changes
    • M Kretzschmar H Franke T Zimmermann Glutathione synthesis and export in experimental liver cirrhosis induced by thioacetamide: Relations to ultrastructural changes Exp Pathol 36 1989 112 122
    • (1989) Exp Pathol , vol.36 , pp. 112-122
    • Kretzschmar, M1    Franke, H2    Zimmermann, T3
  • 41
    • 0024339161 scopus 로고
    • Hepatic actions of levonorgestrel: Correlations between biochemical and morphological findings
    • M Kretzschmar R Giese H Franke Hepatic actions of levonorgestrel: Correlations between biochemical and morphological findings Chem-Biol Interact 70 1989 157 166
    • (1989) Chem-Biol Interact , vol.70 , pp. 157-166
    • Kretzschmar, M1    Giese, R2    Franke, H3
  • 42
    • 0026289245 scopus 로고
    • Ontogenic changes in hepatic glutathione system (synthesis, catabolism, export) in male Uje: WIST rats
    • M Kretzschmar G Bach I Ratzmann Ontogenic changes in hepatic glutathione system (synthesis, catabolism, export) in male Uje: WIST rats J Exp Anim Sci 34 1991 132 139
    • (1991) J Exp Anim Sci , vol.34 , pp. 132-139
    • Kretzschmar, M1    Bach, G2    Ratzmann, I3
  • 43
    • 0026336597 scopus 로고
    • Gamma-glutamyltranspeptidase (GGT) in experimental liver cirrhosis induced by thioacetamide: A biochemical and histochemical study
    • M Kretzschmar G Machnik D Oesterle Gamma-glutamyltranspeptidase (GGT) in experimental liver cirrhosis induced by thioacetamide: A biochemical and histochemical study Exp Pathol 43 1991 195 203
    • (1991) Exp Pathol , vol.43 , pp. 195-203
    • Kretzschmar, M1    Machnik, G2    Oesterle, D3
  • 44
    • 0026440931 scopus 로고
    • Glutathione homeostasis in rats chronically treated with ethanol: Evidence for an increased hepatic GSH export in vivo
    • M Kretzschmar D Reinhardt J Schlechtweg Glutathione homeostasis in rats chronically treated with ethanol: Evidence for an increased hepatic GSH export in vivo Exp Toxic Pathol 44 1992 3244 3348
    • (1992) Exp Toxic Pathol , vol.44 , pp. 3244-3348
    • Kretzschmar, M1    Reinhardt, D2    Schlechtweg, J3
  • 45
    • 0026774165 scopus 로고
    • Glutathione homeostasis and turnover in the totally hepatectomized rat: Evidence for a high glutathione export capacity of extrahepatic tissues
    • M Kretzschmar U Pfeifer G Machnik W Klinger Glutathione homeostasis and turnover in the totally hepatectomized rat: Evidence for a high glutathione export capacity of extrahepatic tissues Exp Toxic Pathol 44 1992 273 281
    • (1992) Exp Toxic Pathol , vol.44 , pp. 273-281
    • Kretzschmar, M1    Pfeifer, U2    Machnik, G3    Klinger, W4
  • 46
    • 85114546789 scopus 로고
    • Prevention of ischemia-reperfusion syndrome after abdominal aortic aneurysmectomy by N-acetylcysteine but not mannitol. Role of glutathione
    • M Kretzschmar U Klein M Palutke W Schirrmeister Prevention of ischemia-reperfusion syndrome after abdominal aortic aneurysmectomy by N-acetylcysteine but not mannitol. Role of glutathione NJ Mmutz W Koller H Benzer Proceedings of the 7th European Congress on Intensive Care Medicine 1994 Monduzzi Editore S.p.A. Bologna 1021 1025
    • (1994) , pp. 1021-1025
    • Kretzschmar, M1    Klein, U2    Palutke, M3    Schirrmeister, W4
  • 47
    • 0018822416 scopus 로고
    • The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis
    • BH Lauterburg Y Vaishnav WG Stillwell JR Mitchell The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis J Pharmacol Exp Ther 213 1980 54 58
    • (1980) J Pharmacol Exp Ther , vol.213 , pp. 54-58
    • Lauterburg, BH1    Vaishnav, Y2    Stillwell, WG3    Mitchell, JR4
  • 48
    • 0021216714 scopus 로고
    • Hepatic glutathione homeostasis in the rat: Efflux accounts for glutathione turnover
    • BH Lauterburg JD Adams JR Mitchell Hepatic glutathione homeostasis in the rat: Efflux accounts for glutathione turnover Hepatology 4 1984 586 590
    • (1984) Hepatology , vol.4 , pp. 586-590
    • Lauterburg, BH1    Adams, JD2    Mitchell, JR3
  • 49
    • 0025075372 scopus 로고
    • Hormonal regulation of glutathione efflux
    • SC Lu C Garcia-Ruiz JK Kuhlenkamp Hormonal regulation of glutathione efflux J Biol Chem 265 1990 16088 16095
    • (1990) J Biol Chem , vol.265 , pp. 16088-16095
    • Lu, SC1    Garcia-Ruiz, C2    Kuhlenkamp, JK3
  • 50
    • 0011888533 scopus 로고
    • Glutathione metabolism in the lung: Inhibition of its synthesis leads to lamellar body and mitochondrial defects
    • J Martensson A Jain W Frayer A Meister Glutathione metabolism in the lung: Inhibition of its synthesis leads to lamellar body and mitochondrial defects Proc Natl Acad Sci USA 86 1989 5296 5300
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5296-5300
    • Martensson, J1    Jain, A2    Frayer, W3    Meister, A4
  • 51
    • 0025256045 scopus 로고
    • Glutathione is required for intestinal function
    • J Martensson A Jain A Meister Glutathione is required for intestinal function Proc Natl Acad Sci USA 87 1990 1715 1719
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1715-1719
    • Martensson, J1    Jain, A2    Meister, A3
  • 52
    • 0024002527 scopus 로고
    • On the discovery of glutathione
    • A Meister On the discovery of glutathione Trends Biochem Sci 13 1988 185 188
    • (1988) Trends Biochem Sci , vol.13 , pp. 185-188
    • Meister, A1
  • 53
    • 0000537243 scopus 로고
    • Metabolism and function of glutathione
    • A Meister Metabolism and function of glutathione D Dolphin R Poulsen O Avramovic Glutathione: Chemical, Biological and Medical Aspects 1989 John Wiley New York 367 474
    • (1989) , pp. 367-474
    • Meister, A1
  • 55
    • 0020478933 scopus 로고
    • Status of mitochondrial pool of glutathione in the isolated hepatocyte
    • MJ Meredith DJ Reed Status of mitochondrial pool of glutathione in the isolated hepatocyte J Biol chem 257 1982 3747 3753
    • (1982) J Biol chem , vol.257 , pp. 3747-3753
    • Meredith, MJ1    Reed, DJ2
  • 56
    • 0011852388 scopus 로고
    • Microsomal glutathione S-transferase: purification, initial characterization and demonstration that is not identical to the cytosolic glutathione S-transferase A, B and C
    • R Morgenstern C Guthenberg JW De Pierre Microsomal glutathione S-transferase: purification, initial characterization and demonstration that is not identical to the cytosolic glutathione S-transferase A, B and C Eur J Biochem 134 1982 591 597
    • (1982) Eur J Biochem , vol.134 , pp. 591-597
    • Morgenstern, R1    Guthenberg, C2    De Pierre, JW3
  • 57
    • 0023846096 scopus 로고
    • Retention of oxidized glutathione in isolated rat liver mitochondria during hydroperoxide treatment
    • K Olafsdottir DJ Reed Retention of oxidized glutathione in isolated rat liver mitochondria during hydroperoxide treatment Biochem Biophys Acta 964 1988 377 382
    • (1988) Biochem Biophys Acta , vol.964 , pp. 377-382
    • Olafsdottir, K1    Reed, DJ2
  • 58
    • 0018801016 scopus 로고
    • Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites
    • L Oppenheimer VP Wellner OW Griffith A Meister Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites J Biol Chem 254 1979 5184 5190
    • (1979) J Biol Chem , vol.254 , pp. 5184-5190
    • Oppenheimer, L1    Wellner, VP2    Griffith, OW3    Meister, A4
  • 59
    • 0023711202 scopus 로고
    • Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness and molecular forms
    • M Ookhtens I Lyon J Fernandez-Checa N Kaplowitz Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness and molecular forms J Clin Invest 82 1988 608 616
    • (1988) J Clin Invest , vol.82 , pp. 608-616
    • Ookhtens, M1    Lyon, I2    Fernandez-Checa, J3    Kaplowitz, N4
  • 60
    • 85114538062 scopus 로고
    • Glutathione biosynthesis and allyl alcohol cytotoxicity in periportal and perivenous rat hepatocytes isolated by digitonin/collagenase perfusion
    • K Penttilä Glutathione biosynthesis and allyl alcohol cytotoxicity in periportal and perivenous rat hepatocytes isolated by digitonin/collagenase perfusion Doctoral thesis, Kuopio 1990
    • (1990)
    • Penttilä, K1
  • 61
    • 0025186107 scopus 로고
    • Hepatic efflux and renal extraction of plasma glutathione: marked differences between healthy subjects and the rat
    • E Perucker H Wernze Hepatic efflux and renal extraction of plasma glutathione: marked differences between healthy subjects and the rat Klin Wschr 68 1990 1008 1012
    • (1990) Klin Wschr , vol.68 , pp. 1008-1012
    • Perucker, E1    Wernze, H2
  • 62
    • 0022551202 scopus 로고
    • Increased hepatic efflux of glutathione after chronic ethanol feeding
    • JL Pierson MC Mitchell Increased hepatic efflux of glutathione after chronic ethanol feeding Biochem Pharmacol 35 1986 1533 1537
    • (1986) Biochem Pharmacol , vol.35 , pp. 1533-1537
    • Pierson, JL1    Mitchell, MC2
  • 64
    • 0343763837 scopus 로고
    • Transport of glutathione, as γ-glutamyl-cysteinylglycyl ester, into liver and kidney
    • RN Puri A Meister Transport of glutathione, as γ-glutamyl-cysteinylglycyl ester, into liver and kidney Proc Natl Acad Sci USA 80 1983 5258 5280
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 5258-5280
    • Puri, RN1    Meister, A2
  • 66
    • 0017753701 scopus 로고
    • The role of methionine in glutathione biosynthesis by isolated hepatocytes
    • DJ Reed S Orrenius The role of methionine in glutathione biosynthesis by isolated hepatocytes Biochem Biophys Res Commun 77 1977 1257 1264
    • (1977) Biochem Biophys Res Commun , vol.77 , pp. 1257-1264
    • Reed, DJ1    Orrenius, S2
  • 67
    • 0016635533 scopus 로고
    • Regulation of γ-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione
    • PG Richman A Meister Regulation of γ-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione J Biol Chem 250 1975 1422 1426
    • (1975) J Biol Chem , vol.250 , pp. 1422-1426
    • Richman, PG1    Meister, A2
  • 68
    • 0019430214 scopus 로고
    • Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment
    • BH Rumack RC Peterson GG Koch IA Amara Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment Arch Intern Med 141 1981 380 385
    • (1981) Arch Intern Med , vol.141 , pp. 380-385
    • Rumack, BH1    Peterson, RC2    Koch, GG3    Amara, IA4
  • 69
    • 0021359583 scopus 로고
    • γ-glutamyl cysteine synthetase. Interactions of essential sulfhydryl group
    • GF Seelig A Meister γ-glutamyl cysteine synthetase. Interactions of essential sulfhydryl group J Biol Chem 259 1984 3534 3538
    • (1984) J Biol Chem , vol.259 , pp. 3534-3538
    • Seelig, GF1    Meister, A2
  • 70
    • 0017395190 scopus 로고
    • γ-glutamyl cysteine synthetase. Further purification, „half of the sites“ reactivity, subunits, and specificity
    • R Sekura A Meister γ-glutamyl cysteine synthetase. Further purification, „half of the sites“ reactivity, subunits, and specificity J Biol Chem 252 1977 2599 2605
    • (1977) J Biol Chem , vol.252 , pp. 2599-2605
    • Sekura, R1    Meister, A2
  • 71
    • 85114544495 scopus 로고
    • Exercise induced oxidative stress: Glutathione dependent antioxidant protection
    • CK Sen Exercise induced oxidative stress: Glutathione dependent antioxidant protection Doctoral thesis, Kuopio 1994
    • (1994)
    • Sen, CK1
  • 72
    • 0026779269 scopus 로고
    • Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization
    • CK Sen E Marin M Kretzschmar O Hänninen Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization J Appl Physiol 73 1992 1265 1272
    • (1992) J Appl Physiol , vol.73 , pp. 1265-1272
    • Sen, CK1    Marin, E2    Kretzschmar, M3    Hänninen, O4
  • 73
    • 0011236269 scopus 로고
    • Properties of glutathione disulfide and glutathione S-conjugate release from perfused rat liver
    • H Sies A Wahlländer C Waydhas Properties of glutathione disulfide and glutathione S-conjugate release from perfused rat liver H Sies A Wendel Functions of glutathione in liver and kidney 1978 Springer Berlin Heidelberg New York 120 126
    • (1978) , pp. 120-126
    • Sies, H1    Wahlländer, A2    Waydhas, C3
  • 74
    • 0018288931 scopus 로고
    • The distribution of glutathione in rat liver lobule
    • MT Smith N Loveridge ED Wills J Chayen The distribution of glutathione in rat liver lobule Biochem J 182 1979 103 108
    • (1979) Biochem J , vol.182 , pp. 103-108
    • Smith, MT1    Loveridge, N2    Wills, ED3    Chayen, J4
  • 75
    • 0344258102 scopus 로고
    • Formation and utilization of γ-glutamyl-cysteine in glutathione synthesis
    • JE Snoke K Bloch Formation and utilization of γ-glutamyl-cysteine in glutathione synthesis J Biol Chem 199 1952 407 414
    • (1952) J Biol Chem , vol.199 , pp. 407-414
    • Snoke, JE1    Bloch, K2
  • 76
    • 0006750037 scopus 로고
    • Synthesis of glutatione from γ-glutamylcysteine
    • JE Snoke S Yanan K Bloch Synthesis of glutatione from γ-glutamylcysteine J Biol Chem 201 1953 573 586
    • (1953) J Biol Chem , vol.201 , pp. 573-586
    • Snoke, JE1    Yanan, S2    Bloch, K3
  • 77
    • 0022464168 scopus 로고
    • Metabolism of sulfur-containing amino acids
    • MH Stipanuk Metabolism of sulfur-containing amino acids Ann Rev Nutr 6 1986 179 209
    • (1986) Ann Rev Nutr , vol.6 , pp. 179-209
    • Stipanuk, MH1
  • 78
    • 0015957347 scopus 로고
    • Studies on the regulation of glutathione level in rat liver
    • N Tateishi T Higashi S Shinya Studies on the regulation of glutathione level in rat liver J Biochem 75 1974 93 103
    • (1974) J Biochem , vol.75 , pp. 93-103
    • Tateishi, N1    Higashi, T2    Shinya, S3
  • 79
    • 0025060737 scopus 로고
    • Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation
    • JP Thomas M Maiorino F Ursini AW Girotti Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation J Biol Chem 265 1990 454 461
    • (1990) J Biol Chem , vol.265 , pp. 454-461
    • Thomas, JP1    Maiorino, M2    Ursini, F3    Girotti, AW4
  • 80
    • 0023748416 scopus 로고
    • Effect of hypoxia on tertrbutylhydroperoxideinduced oxidative injury in hepatocytes
    • D Tribble D Jones D Edmondson Effect of hypoxia on tertrbutylhydroperoxideinduced oxidative injury in hepatocytes Mol Pharmacol 34 1988 413 420
    • (1988) Mol Pharmacol , vol.34 , pp. 413-420
    • Tribble, D1    Jones, D2    Edmondson, D3
  • 81
    • 0023740342 scopus 로고
    • Formation of toxic metabolites from drugs and other xenobiotics by glutathione conjugation
    • PJ Van Bladeren Formation of toxic metabolites from drugs and other xenobiotics by glutathione conjugation Trends Pharmacol Sci 9 1988 295 299
    • (1988) Trends Pharmacol Sci , vol.9 , pp. 295-299
    • Van Bladeren, PJ1
  • 82
    • 0020431315 scopus 로고
    • Drug-induced lipid peroxidation in mice. Glutathione content of liver, kidney and spleen after intravenous administration of free and liposomally-entrapped glutathione
    • A Wendel H Jaeschke Drug-induced lipid peroxidation in mice. Glutathione content of liver, kidney and spleen after intravenous administration of free and liposomally-entrapped glutathione Biochem Pharmacol 31 1982 3607 3611
    • (1982) Biochem Pharmacol , vol.31 , pp. 3607-3611
    • Wendel, A1    Jaeschke, H2
  • 83
    • 0020379908 scopus 로고
    • Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis
    • JM Williamson B Boettcher A Meister Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis Proc Natl Acad Sci USA 79 1982 6246 6249
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 6246-6249
    • Williamson, JM1    Boettcher, B2    Meister, A3
  • 84
    • 0024271763 scopus 로고
    • Hepatic efflux of glutathione by the perfused rat liver: Role of membrane potential differences
    • TL Wright JG Fitz TD Boyer Hepatic efflux of glutathione by the perfused rat liver: Role of membrane potential differences Am J Physiol 255 1988 G547 G555
    • (1988) Am J Physiol , vol.255 , pp. G547-G555
    • Wright, TL1    Fitz, JG2    Boyer, TD3
  • 85
    • 0345033959 scopus 로고
    • Energy sources of glutathione biosynthesis
    • S Yanari JE Snoke K Bloch Energy sources of glutathione biosynthesis J Biol Chem 201 1953 561 571
    • (1953) J Biol Chem , vol.201 , pp. 561-571
    • Yanari, S1    Snoke, JE2    Bloch, K3


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