Ethanol metabolism in ALDH2 knockout mice - Blood acetate levels

Legal Medicine

Volumn 11, Issue SUPPL. 1, 2009, Pages

  Kiyoshi, Ameno ^a   Weihuan, Wang ^a   Mostofa, Jamal ^a   Mitsuru, Kumihashi ^a   Toyoshi, Isse ^b   Toshihiro, Kawamoto ^b   Kyoko, Kitagawa ^c   Keiichi, Nakayama ^d   Iwao, Ijiri ^a   Hiroshi, Kinoshita ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Acetaldehyde; Acetate; ALDH2 KO mice; Ethanol; Metabolism

Indexed keywords

ACETIC ACID; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; C57BL 6 MOUSE; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GAS CHROMATOGRAPHY; KNOCKOUT MOUSE; MOUSE; NONHUMAN;

ACETALDEHYDE; ACETATES; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY, GAS; ETHANOL; FORENSIC TOXICOLOGY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 67349131817     PISSN: 13446223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.legalmed.2009.02.043     Document Type: Article

References (10)

1. Parkinson A. Biotransformation of xenobiotics. In: Klaassen C.D. (Ed). Casarett and Doull's toxicology - the basic science of poisons. 6th publication (2001), McGraw-Hill, New York p. 133-225
2. Sarkola T., Iles M.R., Kohlenberg-Mueller K., and Eriksson C.J.P. Ethanol, acetaldehyde, acetate, and lactate in white men and women: effect of 4-methylpyrazole. Alcohol Clin Exp Res 26 (2002) 239-245
3. Israel Y., Orrego H., and Carmichael F.J. Acetate-mediated effects of ethanol. Alcohol Clin Exp Res 18 (1994) 144-148
4. Lentner C. Geigy scientific tables 3. 8th publication (1984), CIBA-GEIGY, Basel p. 107
5. Kamada M., Yamano S., Irahara M., and Aono T. Estrogen, progesterone - biosynthesis, receptor and action. Nippon Rinsho 55 (1997) 2865-2870
6. Kitagawa K., Kawamoto T., Kunugita N., Tsukiyama T., Okamoto K., Yoshida A., et al. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476 (2000) 306-311
7. Isse T., Matsuno K., Oyama T., Kitagawa K., and Kawamoto T. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin Exp Res 29 (2005) 1959-1964
8. Jamal M., Ameno K., Kumihashi M., Ameno S., Kubota T., Wang W., et al. Microdialysis for the determination of acetaldehyde and ethanol concentrations in the striatum of freely moving rats. J Chromatogr B 798 (2003) 155-158
9. Ameno K., Shirakami K., and Nanikawa R. Determination of blood acetate by head space gas chromatography. Jpn J Alcohol Dependence 19 (1984) 83-89
10. Ritschek W.A., and Kearns G.L. Determination of rate constants. Handbook of basic pharmacokinetics - including clinical application. 5th publication (1999), American Pharmaceutical Association, Washington p. 167-177