Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute

Toxicology

Volumn 335, Issue , 2015, Pages 11-19

  Miousse, Isabelle R ^a   Currie, Richard ^b   Datta, Kaushik ^c   Ellinger Ziegelbauer, Heidrun ^d   French, John E ^e   Harrill, Alison H ^a   Koturbash, Igor ^a   Lawton, Michael ^f   Mann, Derek ^g   Meehan, Richard R ^h   Moggs, Jonathan G ⁱ   O'Lone, Raegan ^j   Rasoulpour, Reza J ^k   Pera, Renee A Reijo ^l   Thompson, Karol ^m  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^c CELGENE CORPORATION   (United States)

^d BAYER PHARMA AG   (Germany)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^f PFIZER INC   (United States)

^g NEWCASTLE UNIVERSITY   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ NOVARTIS PHARMA AG   (Switzerland)

^j ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

^k DOW CHEMICAL COMPANY   (United States)

^l MONTANA STATE UNIVERSITY   (United States)

^m CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

more..

Author keywords

Biomarkers; Epigenetics; Models; Safety assessment; Stem cells; Transgenerational effects

Indexed keywords

AGRICULTURAL CHEMICAL; ANTIEMETIC AGENT; AZACITIDINE; BELINOSTAT; BIOLOGICAL MARKER; BUTYRIC ACID; DECITABINE; ROMIDEPSIN; TRICHOSTATIN A; VINCLOZOLIN; VORINOSTAT; XENOBIOTIC AGENT; GENETIC MARKER;

CHEMICAL SAFETY; DOSE RESPONSE; DRUG DESIGN; DRUG SAFETY; ENVIRONMENT; ENVIRONMENTAL HEALTH; ENVIRONMENTAL SCIENCE; EPIGENETICS; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; GENOME; HEALTH HAZARD; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INDUSTRY; NEOPLASM; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; POPULATION GENETICS; PRIORITY JOURNAL; PRODUCT SAFETY; REVIEW; RISK ASSESSMENT; SCIENCE; STEM CELL; TOXICOLOGY; TRANSFORMED CELL LINE; VIRUS LATENCY; ANIMAL; BIOASSAY; DNA METHYLATION; DRUG EFFECTS; ENVIRONMENTAL MONITORING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC MARKER; PATHOLOGY; STANDARDS; TOXICITY TESTING;

ANIMALS; CELLULAR REPROGRAMMING; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDPOINT DETERMINATION; ENVIRONMENTAL MONITORING; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC MARKERS; HUMANS; RISK ASSESSMENT; STEM CELLS; TOXICITY TESTS;

EID: 84937020187     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.06.009     Document Type: Review

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