Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome

Genome Biology

Volumn 13, Issue 10, 2012, Pages

  Thomson, John P ^a   Lempiäinen, Harri ^b   Hackett, Jamie A ^a   Nestor, Colm E ^a,c   Müller, Arne ^b   Bolognani, Federico ^b   Oakeley, Edward J ^b   Schübeler, Dirk ^d   Terranova, Rémi ^b   Reinhardt, Diana ^a,c   Moggs, Jonathan G ^b   Meehan, Richard R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; CYTOCHROME P450 2B; CYTOCHROME P450 2C; HISTONE; HISTONE H3K27ME3; HISTONE H3K36ME3; HISTONE H3K4ME2; PHENOBARBITAL; UNCLASSIFIED DRUG; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CONTROLLED STUDY; CPG ISLAND; CYTOCHROME P450 2B GENE; CYTOCHROME P450 2C GENE; DNA METHYLATION; DNA MODIFICATION; GENE; GENE ACTIVATION; GENE CONVERSION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENETIC ANALYSIS; HISTONE MODIFICATION; LIVER CARCINOGENESIS; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RISK ASSESSMENT; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; UPREGULATION; XENOBIOTIC METABOLISM; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DNA MICROARRAY; DRUG EFFECTS; EPIGENETICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; METABOLISM;

RODENTIA;

ANIMALS; CYTOSINE; DNA METHYLATION; EPIGENOMICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONES; LIVER; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOBARBITAL; PROMOTER REGIONS, GENETIC;

EID: 84866847877     PISSN: None     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2012-13-10-R93     Document Type: Article

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