XMutation in folate metabolism causes epigenetic instability and transgenerational effects on development

Cell

Volumn 155, Issue 1, 2013, Pages

  Padmanabhan, Nisha ^a   Jia, Dongxin ^b   Geary Joo, Colleen ^c   Wu, Xuchu ^b   Ferguson Smith, Anne C ^a   Fung, Ernest ^c   Bieda, Mark C ^b,c   Snyder, Floyd F ^b,c   Gravel, Roy A ^b,c   Cross, James C ^b,c   Watson, Erica D ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METHIONINE SYNTHASE REDUCTASE; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; FOLIC ACID;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENITAL HEART MALFORMATION; CONGENITAL MALFORMATION; CONTROLLED STUDY; CROWN RUMP LENGTH; DEVELOPMENTAL DISORDER; DNA METHYLATION; DNA SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; EMBRYONIC STEM CELL; FEMALE; FOLATE METABOLISM; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENOMIC INSTABILITY; GENOTYPE; GRANDPARENT; HYPERHOMOCYSTEINEMIA; INHERITANCE; INTRAUTERINE GROWTH RETARDATION; INTRON; MALE; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PHENOTYPE; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROGENY; SOUTHERN BLOTTING; TANDEM MASS SPECTROMETRY; WILD TYPE; ANIMAL; ANIMAL EMBRYO; CONGENITAL DISORDER; CROSS BREEDING; GENETIC EPIGENESIS; GENETICS; METABOLISM; MUTATION;

MUS;

ANIMALS; CONGENITAL ABNORMALITIES; CROSSES, GENETIC; DNA METHYLATION; EMBRYO, MAMMALIAN; EPIGENESIS, GENETIC; FEMALE; FERREDOXIN-NADP REDUCTASE; FETAL GROWTH RETARDATION; FOLIC ACID; MALE; MICE; MUTATION;

EID: 84884862385     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.09.002     Document Type: Article

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