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Volumn 41, Issue 11, 2013, Pages 5639-5654

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; BIOLOGICAL MARKER; PHENOBARBITAL;

EID: 84878843769     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt232     Document Type: Article
Times cited : (79)

References (80)
  • 1
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev., 16, 6-21.
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 2
    • 82955207588 scopus 로고    scopus 로고
    • Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
    • Wu, H. and Zhang, Y. (2011) Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev., 25, 2436-2452.
    • (2011) Genes Dev. , vol.25 , pp. 2436-2452
    • Wu, H.1    Zhang, Y.2
  • 4
    • 79954457998 scopus 로고    scopus 로고
    • Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
    • Wu, H., D'Alessio, A.C., Ito, S., Wang, Z., Cui, K., Zhao, K., Sun, Y.E. and Zhang, Y. (2011) Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev., 25, 679-684.
    • (2011) Genes Dev. , vol.25 , pp. 679-684
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3    Wang, Z.4    Cui, K.5    Zhao, K.6    Sun, Y.E.7    Zhang, Y.8
  • 5
    • 79956292024 scopus 로고    scopus 로고
    • Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
    • Wu, H., D'Alessio, A.C., Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Eve Sun, Y. and Zhang, Y. (2011) Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature, 473, 389-393.
    • (2011) Nature , vol.473 , pp. 389-393
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3    Xia, K.4    Wang, Z.5    Cui, K.6    Zhao, K.7    Eve Sun, Y.8    Zhang, Y.9
  • 8
    • 79959209733 scopus 로고    scopus 로고
    • 5-hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells
    • Stroud, H., Feng, S., Morey Kinney, S., Pradhan, S. and Jacobsen, S.E. (2011) 5-hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol., 12, R54.
    • (2011) Genome Biol. , vol.12
    • Stroud, H.1    Feng, S.2    Morey Kinney, S.3    Pradhan, S.4    Jacobsen, S.E.5
  • 9
    • 79955948324 scopus 로고    scopus 로고
    • Genome-wide regulation of 5hmC, 5mC, and gene expression by tet1 hydroxylase in mouse embryonic stem cells
    • Xu, Y., Wu, F., Tan, L., Kong, L., Xiong, L., Deng, J., Barbera, A.J., Zheng, L., Zhang, H., Huang, S. et al. (2011) Genome-wide regulation of 5hmC, 5mC, and gene expression by tet1 hydroxylase in mouse embryonic stem cells. Mol. Cell, 42, 451-464.
    • (2011) Mol. Cell , vol.42 , pp. 451-464
    • Xu, Y.1    Wu, F.2    Tan, L.3    Kong, L.4    Xiong, L.5    Deng, J.6    Barbera, A.J.7    Zheng, L.8    Zhang, H.9    Huang, S.10
  • 13
    • 84864311315 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
    • Bocker, M.T., Tuorto, F., Raddatz, G., Musch, T., Yang, F.C., Xu, M., Lyko, F. and Breiling, A. (2012) Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nat. Commun., 3, 818.
    • (2012) Nat. Commun. , vol.3 , pp. 818
    • Bocker, M.T.1    Tuorto, F.2    Raddatz, G.3    Musch, T.4    Yang, F.C.5    Xu, M.6    Lyko, F.7    Breiling, A.8
  • 14
    • 84861221693 scopus 로고    scopus 로고
    • Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
    • Booth, M.J., Branco, M.R., Ficz, G., Oxley, D., Krueger, F., Reik, W. and Balasubramanian, S. (2012) Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science, 336, 934-937.
    • (2012) Science , vol.336 , pp. 934-937
    • Booth, M.J.1    Branco, M.R.2    Ficz, G.3    Oxley, D.4    Krueger, F.5    Reik, W.6    Balasubramanian, S.7
  • 22
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito, S., D'Alessio, A.C., Taranova, O.V., Hong, K., Sowers, L.C. and Zhang, Y. (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature, 466, 1129-1133.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 23
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito, S., Shen, L., Dai, Q., Wu, S.C., Collins, L.B., Swenberg, J.A., He, C. and Zhang, Y. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science, 333, 1300-1303.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 25
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He, Y.F., Li, B.Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L. et al. (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science, 333, 1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6    Ding, J.7    Jia, Y.8    Chen, Z.9    Li, L.10
  • 26
    • 82655187105 scopus 로고    scopus 로고
    • Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development
    • Inoue, A., Shen, L., Dai, Q., He, C. and Zhang, Y. (2011) Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res., 21, 1670-1676.
    • (2011) Cell Res. , vol.21 , pp. 1670-1676
    • Inoue, A.1    Shen, L.2    Dai, Q.3    He, C.4    Zhang, Y.5
  • 27
    • 80054097425 scopus 로고    scopus 로고
    • Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos
    • Inoue, A. and Zhang, Y. (2011) Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science, 334, 194.
    • (2011) Science , vol.334 , pp. 194
    • Inoue, A.1    Zhang, Y.2
  • 28
    • 84872770694 scopus 로고    scopus 로고
    • Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
    • Hackett, J.A., Sengupta, R., Zylicz, J.J., Murakami, K., Lee, C., Down, T.A. and Surani, M.A. (2012) Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science, 339, 448-452.
    • (2012) Science , vol.339 , pp. 448-452
    • Hackett, J.A.1    Sengupta, R.2    Zylicz, J.J.3    Murakami, K.4    Lee, C.5    Down, T.A.6    Surani, M.A.7
  • 30
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian, C.G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K., Xu, W., Tan, L., Hu, Y., Zhan, Q. et al. (2012) Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell, 150, 1135-1146.
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1    Xu, Y.2    Ceol, C.3    Wu, F.4    Larson, A.5    Dresser, K.6    Xu, W.7    Tan, L.8    Hu, Y.9    Zhan, Q.10
  • 32
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa, M.E., Abdel-Wahab, O., Lu, C., Ward, P.S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H.F. et al. (2010) Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell, 18, 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6    Li, Y.7    Bhagwat, N.8    Vasanthakumar, A.9    Fernandez, H.F.10
  • 33
    • 84868103289 scopus 로고    scopus 로고
    • Tet2 facilitates the derepression of myeloid target genes during cebpalpha-induced transdifferentiation of pre-B cells
    • Kallin, E.M., Rodriguez-Ubreva, J., Christensen, J., Cimmino, L., Aifantis, I., Helin, K., Ballestar, E. and Graf, T. (2012) Tet2 facilitates the derepression of myeloid target genes during cebpalpha-induced transdifferentiation of pre-B cells. Mol. Cell, 48, 266-276.
    • (2012) Mol. Cell , vol.48 , pp. 266-276
    • Kallin, E.M.1    Rodriguez-Ubreva, J.2    Christensen, J.3    Cimmino, L.4    Aifantis, I.5    Helin, K.6    Ballestar, E.7    Graf, T.8
  • 34
    • 79953035873 scopus 로고    scopus 로고
    • Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice
    • Lempiainen, H., Muller, A., Brasa, S., Teo, S.S., Roloff, T.C., Morawiec, L., Zamurovic, N., Vicart, A., Funhoff, E., Couttet, P. et al. (2011) Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice. PLoS One, 6, e18216.
    • (2011) PLoS One , vol.6
    • Lempiainen, H.1    Muller, A.2    Brasa, S.3    Teo, S.S.4    Roloff, T.C.5    Morawiec, L.6    Zamurovic, N.7    Vicart, A.8    Funhoff, E.9    Couttet, P.10
  • 35
    • 33847331654 scopus 로고    scopus 로고
    • Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    • Phillips, J.M., Yamamoto, Y., Negishi, M., Maronpot, R.R. and Goodman, J.I. (2007) Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. Toxicol. Sci., 96, 72-82.
    • (2007) Toxicol. Sci. , vol.96 , pp. 72-82
    • Phillips, J.M.1    Yamamoto, Y.2    Negishi, M.3    Maronpot, R.R.4    Goodman, J.I.5
  • 36
    • 0036094163 scopus 로고    scopus 로고
    • Epigenetics and DNA methylation come of age in toxicology
    • Watson, R.E. and Goodman, J.I. (2002) Epigenetics and DNA methylation come of age in toxicology. Toxicol. Sci., 67, 11-16.
    • (2002) Toxicol. Sci. , vol.67 , pp. 11-16
    • Watson, R.E.1    Goodman, J.I.2
  • 38
    • 0037108681 scopus 로고    scopus 로고
    • Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital
    • Loeppen, S., Schneider, D., Gaunitz, F., Gebhardt, R., Kurek, R., Buchmann, A. and Schwarz, M. (2002) Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res., 62, 5685-5688.
    • (2002) Cancer Res. , vol.62 , pp. 5685-5688
    • Loeppen, S.1    Schneider, D.2    Gaunitz, F.3    Gebhardt, R.4    Kurek, R.5    Buchmann, A.6    Schwarz, M.7
  • 39
    • 15644384598 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
    • Rencurel, F., Stenhouse, A., Hawley, S.A., Friedberg, T., Hardie, D.G., Sutherland, C. and Wolf, C.R. (2005) AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J. Biol. Chem., 280, 4367-4373.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4367-4373
    • Rencurel, F.1    Stenhouse, A.2    Hawley, S.A.3    Friedberg, T.4    Hardie, D.G.5    Sutherland, C.6    Wolf, C.R.7
  • 40
  • 41
    • 80052245751 scopus 로고    scopus 로고
    • DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival
    • Luk, J.M., Burchard, J., Zhang, C., Liu, A.M., Wong, K.F., Shek, F.H., Lee, N.P., Fan, S.T., Poon, R.T., Ivanovska, I. et al. (2011) DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival. J. Biol. Chem., 286, 30706-30713.
    • (2011) J. Biol. Chem. , vol.286 , pp. 30706-30713
    • Luk, J.M.1    Burchard, J.2    Zhang, C.3    Liu, A.M.4    Wong, K.F.5    Shek, F.H.6    Lee, N.P.7    Fan, S.T.8    Poon, R.T.9    Ivanovska, I.10
  • 43
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth, G.K. (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol., 3, Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , pp. 3
    • Smyth, G.K.1
  • 44
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad, B.M., Irizarry, R.A., Astrand, M. and Speed, T.P. (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics, 19, 185-193.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 46
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber, M., Hellmann, I., Stadler, M.B., Ramos, L., Paabo, S., Rebhan, M. and Schubeler, D. (2007) Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet., 39, 457-466.
    • (2007) Nat. Genet. , vol.39 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3    Ramos, L.4    Paabo, S.5    Rebhan, M.6    Schubeler, D.7
  • 47
    • 84869397620 scopus 로고    scopus 로고
    • MeDIP-HMM: Genome-wide identification of distinct DNA methylation states from high-density tiling arrays
    • Seifert, M., Cortijo, S., Colome-Tatche, M., Johannes, F., Roudier, F. and Colot, V. (2012) MeDIP-HMM: genome-wide identification of distinct DNA methylation states from high-density tiling arrays. Bioinformatics, 28, 2930-2939.
    • (2012) Bioinformatics , vol.28 , pp. 2930-2939
    • Seifert, M.1    Cortijo, S.2    Colome-Tatche, M.3    Johannes, F.4    Roudier, F.5    Colot, V.6
  • 49
    • 78651251739 scopus 로고    scopus 로고
    • Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias
    • Nair, S.S., Coolen, M.W., Stirzaker, C., Song, J.Z., Statham, A.L., Strbenac, D., Robinson, M.D. and Clark, S.J. (2011) Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias. Epigenetics, 6, 34-44.
    • (2011) Epigenetics , vol.6 , pp. 34-44
    • Nair, S.S.1    Coolen, M.W.2    Stirzaker, C.3    Song, J.Z.4    Statham, A.L.5    Strbenac, D.6    Robinson, M.D.7    Clark, S.J.8
  • 50
    • 0033924973 scopus 로고    scopus 로고
    • Histometrical and threedimensional analyses of liver hematopoiesis in the mouse embryo
    • Sasaki, K. and Sonoda, Y. (2000) Histometrical and threedimensional analyses of liver hematopoiesis in the mouse embryo. Arch. Histol. Cytol., 63, 137-146.
    • (2000) Arch. Histol. Cytol. , vol.63 , pp. 137-146
    • Sasaki, K.1    Sonoda, Y.2
  • 52
    • 34249729341 scopus 로고    scopus 로고
    • Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns
    • Otu, H.H., Naxerova, K., Ho, K., Can, H., Nesbitt, N., Libermann, T.A. and Karp, S.J. (2007) Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns. J. Biol. Chem., 282, 11197-11204.
    • (2007) J. Biol. Chem. , vol.282 , pp. 11197-11204
    • Otu, H.H.1    Naxerova, K.2    Ho, K.3    Can, H.4    Nesbitt, N.5    Libermann, T.A.6    Karp, S.J.7
  • 54
    • 0035936026 scopus 로고    scopus 로고
    • Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors
    • Aydinlik, H., Nguyen, T.D., Moennikes, O., Buchmann, A. and Schwarz, M. (2001) Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene, 20, 7812-7816.
    • (2001) Oncogene , vol.20 , pp. 7812-7816
    • Aydinlik, H.1    Nguyen, T.D.2    Moennikes, O.3    Buchmann, A.4    Schwarz, M.5
  • 55
  • 56
    • 84869392308 scopus 로고    scopus 로고
    • Mapping recently identified nucleotide variants in the genome and transcriptome
    • Song, C.X., Yi, C. and He, C. (2012) Mapping recently identified nucleotide variants in the genome and transcriptome. Nat. Biotechnol., 30, 1107-1116.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 1107-1116
    • Song, C.X.1    Yi, C.2    He, C.3
  • 57
    • 79960249232 scopus 로고    scopus 로고
    • Genomic mapping of 5-hydroxymethylcytosine in the human brain
    • Jin, S.G., Wu, X., Li, A.X. and Pfeifer, G.P. (2011) Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res., 39, 5015-5024.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 5015-5024
    • Jin, S.G.1    Wu, X.2    Li, A.X.3    Pfeifer, G.P.4
  • 59
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis, S. and Heintz, N. (2009) The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science, 324, 929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 60
    • 77953532417 scopus 로고    scopus 로고
    • Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells
    • Liu, L., Luo, G.Z., Yang, W., Zhao, X., Zheng, Q., Lv, Z., Li, W., Wu, H.J., Wang, L., Wang, X.J. et al. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J. Biol. Chem., 285, 19483-19490.
    • (2010) J. Biol. Chem. , vol.285 , pp. 19483-19490
    • Liu, L.1    Luo, G.Z.2    Yang, W.3    Zhao, X.4    Zheng, Q.5    Lv, Z.6    Li, W.7    Wu, H.J.8    Wang, L.9    Wang, X.J.10
  • 62
    • 67650735625 scopus 로고    scopus 로고
    • The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors
    • Phillips, J.M., Burgoon, L.D. and Goodman, J.I. (2009) The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors. Toxicol. Sci., 110, 319-333.
    • (2009) Toxicol. Sci. , vol.110 , pp. 319-333
    • Phillips, J.M.1    Burgoon, L.D.2    Goodman, J.I.3
  • 63
    • 66149107971 scopus 로고    scopus 로고
    • Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice
    • Phillips, J.M., Burgoon, L.D. and Goodman, J.I. (2009) Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice. Toxicol. Sci., 109, 193-205.
    • (2009) Toxicol. Sci. , vol.109 , pp. 193-205
    • Phillips, J.M.1    Burgoon, L.D.2    Goodman, J.I.3
  • 64
    • 3042697182 scopus 로고    scopus 로고
    • Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital
    • Calvisi, D.F., Ladu, S., Factor, V.M. and Thorgeirsson, S.S. (2004) Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital. Carcinogenesis, 25, 901-908.
    • (2004) Carcinogenesis , vol.25 , pp. 901-908
    • Calvisi, D.F.1    Ladu, S.2    Factor, V.M.3    Thorgeirsson, S.S.4
  • 65
    • 33845705732 scopus 로고    scopus 로고
    • Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma
    • Chua, M.S., Sun, H., Cheung, S.T., Mason, V., Higgins, J., Ross, D.T., Fan, S.T. and So, S. (2007) Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod. Pathol., 20, 76-83.
    • (2007) Mod. Pathol. , vol.20 , pp. 76-83
    • Chua, M.S.1    Sun, H.2    Cheung, S.T.3    Mason, V.4    Higgins, J.5    Ross, D.T.6    Fan, S.T.7    So, S.8
  • 66
    • 5644295430 scopus 로고    scopus 로고
    • The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    • Yamamoto, Y., Moore, R., Goldsworthy, T.L., Negishi, M. and Maronpot, R.R. (2004) The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res., 64, 7197-7200.
    • (2004) Cancer Res. , vol.64 , pp. 7197-7200
    • Yamamoto, Y.1    Moore, R.2    Goldsworthy, T.L.3    Negishi, M.4    Maronpot, R.R.5
  • 68
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski, P., Zelko, I., Sueyoshi, T. and Negishi, M. (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell. Biol., 18, 5652-5658.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 69
    • 0033652116 scopus 로고    scopus 로고
    • Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene
    • Kawamoto, T., Kakizaki, S., Yoshinari, K. and Negishi, M. (2000) Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Mol. Endocrinol., 14, 1897-1905.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1897-1905
    • Kawamoto, T.1    Kakizaki, S.2    Yoshinari, K.3    Negishi, M.4
  • 70
    • 77953737472 scopus 로고    scopus 로고
    • The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver
    • Konno, Y., Kamino, H., Moore, R., Lih, F., Tomer, K.B., Zeldin, D.C., Goldstein, J.A. and Negishi, M. (2010) The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. Drug Metab. Dispos., 38, 1177-1182.
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1177-1182
    • Konno, Y.1    Kamino, H.2    Moore, R.3    Lih, F.4    Tomer, K.B.5    Zeldin, D.C.6    Goldstein, J.A.7    Negishi, M.8
  • 71
    • 38949094492 scopus 로고    scopus 로고
    • Cytochrome p450 and chemical toxicology
    • Guengerich, F.P. (2008) Cytochrome p450 and chemical toxicology. Chem. Res. Toxicol., 21, 70-83.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 70-83
    • Guengerich, F.P.1
  • 74
    • 84858069933 scopus 로고    scopus 로고
    • Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: The dalcetrapib experience
    • Hoflack, J.C., Mueller, L., Fowler, S., Braendli-Baiocco, A., Flint, N., Kuhlmann, O., Singer, T. and Roth, A. (2012) Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: the dalcetrapib experience. Toxicol. Appl. Pharmacol., 259, 355-365.
    • (2012) Toxicol. Appl. Pharmacol. , vol.259 , pp. 355-365
    • Hoflack, J.C.1    Mueller, L.2    Fowler, S.3    Braendli-Baiocco, A.4    Flint, N.5    Kuhlmann, O.6    Singer, T.7    Roth, A.8
  • 77
    • 33846581497 scopus 로고    scopus 로고
    • Loss of imprinting and cancer
    • Jelinic, P. and Shaw, P. (2007) Loss of imprinting and cancer. J. Pathol., 211, 261-268.
    • (2007) J. Pathol. , vol.211 , pp. 261-268
    • Jelinic, P.1    Shaw, P.2
  • 78
    • 70449366626 scopus 로고    scopus 로고
    • Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells
    • Wei, W., Chua, M.S., Grepper, S. and So, S.K. (2009) Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells. Mol. Cancer, 8, 76.
    • (2009) Mol. Cancer , vol.8 , pp. 76
    • Wei, W.1    Chua, M.S.2    Grepper, S.3    So, S.K.4
  • 79
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • Wei, P., Zhang, J., Egan-Hafley, M., Liang, S. and Moore, D.D. (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature, 407, 920-923.
    • (2000) Nature , vol.407 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Hafley, M.3    Liang, S.4    Moore, D.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.