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Volumn 6, Issue 3, 2015, Pages 177-190

Liver X receptors as regulators of metabolism

Author keywords

cholesterol; nuclear receptor; oxysterol; transcription

Indexed keywords

MAMMALIA;

EID: 84936773549     PISSN: 18685021     EISSN: 1868503X     Source Type: Journal    
DOI: 10.1515/bmc-2015-0007     Document Type: Review
Times cited : (36)

References (104)
  • 2
    • 78651084546 scopus 로고    scopus 로고
    • Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity
    • Korach-Andre M, Archer A, Barros RP, Parini P, Gustafsson JA. Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc Natl Acad Sci USA 2011; 108: 403-8.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 403-408
    • Korach-Andre, M.1    Archer, A.2    Barros, R.P.3    Parini, P.4    Gustafsson, J.A.5
  • 9
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet P, Luo Y, Wang N, Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 2000; 275: 28240-5.
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 12
    • 84901937811 scopus 로고    scopus 로고
    • Liver X receptors in lipid metabolism: Opportunities for drug discovery
    • Hong C, Tontonoz P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nature Rev Drug Discov 2014; 13: 433-44.
    • (2014) Nature Rev Drug Discov , vol.13 , pp. 433-444
    • Hong, C.1    Tontonoz, P.2
  • 14
    • 34548487132 scopus 로고    scopus 로고
    • Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals
    • Kase ET, Thoresen GH, Westerlund S, Hojlund K, Rustan AC, Gaster M. Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals. Diabetologia 2007; 50: 2171-80.
    • (2007) Diabetologia , vol.50 , pp. 2171-2180
    • Kase, E.T.1    Thoresen, G.H.2    Westerlund, S.3    Hojlund, K.4    Rustan, A.C.5    Gaster, M.6
  • 19
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • Kalaany NY, Mangelsdorf DJ. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006; 68: 159-91.
    • (2006) Annu Rev Physiol , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 24
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 1998; 93: 693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 26
    • 33846864235 scopus 로고    scopus 로고
    • Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha
    • van der Veen JN, Havinga R, Bloks VW, Groen AK, Kuipers F. Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha. J Lipid Res 2007; 48: 337-47.
    • (2007) J Lipid Res , vol.48 , pp. 337-347
    • Van Der-Veen, J.N.1    Havinga, R.2    Bloks, V.W.3    Groen, A.K.4    Kuipers, F.5
  • 27
    • 0038614979 scopus 로고    scopus 로고
    • Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
    • Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem 2003; 278: 15565-70.
    • (2003) J Biol Chem , vol.278 , pp. 15565-15570
    • Yu, L.1    York, J.2    Von Bergmann, K.3    Lutjohann, D.4    Cohen, J.C.5    Hobbs, H.H.6
  • 28
    • 84875260304 scopus 로고    scopus 로고
    • Atherosclerosis: Lessons from LXR and the intestine
    • Bonamassa B, Moschetta A. Atherosclerosis: lessons from LXR and the intestine. Trends Endocrinol Metab 2013; 24: 120-8.
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 120-128
    • Bonamassa, B.1    Moschetta, A.2
  • 32
    • 42149130968 scopus 로고    scopus 로고
    • Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish
    • Archer A, Lauter G, Hauptmann G, Mode A, Gustafsson JA. Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish. Dev Dyn 2008; 237: 1090-8.
    • (2008) Dev Dyn , vol.237 , pp. 1090-1098
    • Archer, A.1    Lauter, G.2    Hauptmann, G.3    Mode, A.4    Gustafsson, J.A.5
  • 33
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • Repa JJ, Mangelsdorf DJ. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Ann Rev Cell Dev Biol 2000; 16: 459-81.
    • (2000) Ann Rev Cell Dev Biol , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 34
    • 0347034082 scopus 로고    scopus 로고
    • Characterization of the human ABCG1 gene: Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
    • Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem 2001; 276: 39438-47.
    • (2001) J Biol Chem , vol.276 , pp. 39438-39447
    • Kennedy, M.A.1    Venkateswaran, A.2    Tarr, P.T.3    Xenarios, I.4    Kudoh, J.5    Shimizu, N.6    Edwards, P.A.7
  • 37
    • 0035900749 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta
    • Zhang Y, Repa JJ, Gauthier K, Mangelsdorf DJ. Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. J Biol Chem 2001; 276: 43018-24.
    • (2001) J Biol Chem , vol.276 , pp. 43018-43024
    • Zhang, Y.1    Repa, J.J.2    Gauthier, K.3    Mangelsdorf, D.J.4
  • 42
    • 0038448097 scopus 로고    scopus 로고
    • Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux
    • Wang N, Tall AR. Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux. Arterioscler Thromb Vasc Biol 2003; 23: 1178-84.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1178-1184
    • Wang, N.1    Tall, A.R.2
  • 45
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Investig 2002; 109: 1125-31.
    • (2002) J Clin Investig , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 50
    • 33748655454 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    • Chu K, Miyazaki M, Man WC, Ntambi JM. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol 2006; 26: 6786-98.
    • (2006) Mol Cell Biol , vol.26 , pp. 6786-6798
    • Chu, K.1    Miyazaki, M.2    Man, W.C.3    Ntambi, J.M.4
  • 53
    • 84910086832 scopus 로고    scopus 로고
    • Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice
    • Mohammadi A, Oshaghi EA. Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice. J Diabetes Metab Disord 2014; 13: 20.
    • (2014) J Diabetes Metab Disord , vol.13 , pp. 20
    • Mohammadi, A.1    Oshaghi, E.A.2
  • 58
    • 84904548332 scopus 로고    scopus 로고
    • Macrophage-independent regulation of reverse cholesterol transport by liver X receptors
    • Breevoort SR, Angdisen J, Schulman IG. Macrophage-independent regulation of reverse cholesterol transport by liver X receptors. Arterioscler Thromb Vasc Biol 2014; 34: 1650-60.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1650-1660
    • Breevoort, S.R.1    Angdisen, J.2    Schulman, I.G.3
  • 59
    • 84906861574 scopus 로고    scopus 로고
    • Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids
    • Cruz-Garcia L, Schlegel A. Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. J Lipid Res 2014; 55: 1944-58.
    • (2014) J Lipid Res , vol.55 , pp. 1944-1958
    • Cruz-Garcia, L.1    Schlegel, A.2
  • 60
    • 84891862000 scopus 로고    scopus 로고
    • LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression
    • Kannisto K, Gafvels M, Jiang ZY, Slatis K, Hu X, Jorns C, Steffensen KR, Eggertsen G. LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression. Lipids 2014; 49: 71-83.
    • (2014) Lipids , vol.49 , pp. 71-83
    • Kannisto, K.1    Gafvels, M.2    Jiang, Z.Y.3    Slatis, K.4    Hu, X.5    Jorns, C.6    Steffensen, K.R.7    Eggertsen, G.8
  • 62
    • 33749322956 scopus 로고    scopus 로고
    • Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels
    • Brunham LR, Kruit JK, Pape TD, Parks JS, Kuipers F, Hayden MR. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 2006; 99: 672-4.
    • (2006) Circ Res , vol.99 , pp. 672-674
    • Brunham, L.R.1    Kruit, J.K.2    Pape, T.D.3    Parks, J.S.4    Kuipers, F.5    Hayden, M.R.6
  • 63
    • 53149134712 scopus 로고    scopus 로고
    • Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8
    • Calpe-Berdiel L, Rotllan N, Fievet C, Roig R, Blanco-Vaca F, Escola-Gil JC. Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J Lipid Research 2008; 49: 1904-11.
    • (2008) J Lipid Research , vol.49 , pp. 1904-1911
    • Calpe-Berdiel, L.1    Rotllan, N.2    Fievet, C.3    Roig, R.4    Blanco-Vaca, F.5    Escola-Gil, J.C.6
  • 64
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plosch T, Kok T, Bloks VW, Smit MJ, Havinga R, Chimini G, Groen AK, Kuipers F. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem 2002; 277: 33870-7.
    • (2002) J Biol Chem , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6    Groen, A.K.7    Kuipers, F.8
  • 66
    • 84867904787 scopus 로고    scopus 로고
    • LXRbeta activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile
    • Hu X, Steffensen KR, Jiang ZY, Parini P, Gustafsson JA, Gafvels M, Eggertsen G. LXRbeta activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile. J Int Med 2012; 272: 452-64.
    • (2012) J Int Med , vol.272 , pp. 452-464
    • Hu, X.1    Steffensen, K.R.2    Jiang, Z.Y.3    Parini, P.4    Gustafsson, J.A.5    Gafvels, M.6    Eggertsen, G.7
  • 68
    • 84878778804 scopus 로고    scopus 로고
    • Body fat distribution and insulin resistance
    • Patel P, Abate N. Body fat distribution and insulin resistance. Nutrients 2013; 5: 2019-27.
    • (2013) Nutrients , vol.5 , pp. 2019-2027
    • Patel, P.1    Abate, N.2
  • 69
    • 84893372286 scopus 로고    scopus 로고
    • LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes
    • Dib L, Bugge A, Collins S. LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes. J Lipid Res 2014; 55: 247-57.
    • (2014) J Lipid Res , vol.55 , pp. 247-257
    • Dib, L.1    Bugge, A.2    Collins, S.3
  • 73
    • 84903386033 scopus 로고    scopus 로고
    • Regulation of insulin resistance and adiponectin signaling in adipose tissue by liver X receptor activation highlights a cross-talk with PPARgamma
    • Zheng F, Zhang S, Lu W, Wu F, Yin X, Yu D, Pan Q, Li H. Regulation of insulin resistance and adiponectin signaling in adipose tissue by liver X receptor activation highlights a cross-talk with PPARgamma. PloS One 2014; 9:e101269.
    • (2014) PloS One , vol.9 , pp. e101269
    • Zheng, F.1    Zhang, S.2    Lu, W.3    Wu, F.4    Yin, X.5    Yu, D.6    Pan, Q.7    Li, H.8
  • 75
    • 84869785022 scopus 로고    scopus 로고
    • Rhein protects against obesity and related metabolic disorders through liver X receptor-mediated uncoupling protein 1 upregulation in brown adipose tissue
    • Sheng X, Zhu X, Zhang Y, Cui G, Peng L, Lu X, Zang YQ. Rhein protects against obesity and related metabolic disorders through liver X receptor-mediated uncoupling protein 1 upregulation in brown adipose tissue. Int J Biol Sci 2012; 8: 1375-84.
    • (2012) Int J Biol Sci , vol.8 , pp. 1375-1384
    • Sheng, X.1    Zhu, X.2    Zhang, Y.3    Cui, G.4    Peng, L.5    Lu, X.6    Zang, Y.Q.7
  • 78
    • 84907486509 scopus 로고    scopus 로고
    • Androgen receptor roles in insulin resistance and obesity in males: The linkage of androgen-deprivation therapy to metabolic syndrome
    • Yu IC, Lin HY, Sparks JD, Yeh S, Chang C. Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome. Diabetes 2014; 63: 3180-8.
    • (2014) Diabetes , vol.63 , pp. 3180-3188
    • Yu, I.C.1    Lin, H.Y.2    Sparks, J.D.3    Yeh, S.4    Chang, C.5
  • 82
    • 33745298324 scopus 로고    scopus 로고
    • Gonadal hormones determine sensitivity to central leptin and insulin
    • Clegg DJ, Brown LM, Woods SC, Benoit SC. Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 2006; 55: 978-87.
    • (2006) Diabetes , vol.55 , pp. 978-987
    • Clegg, D.J.1    Brown, L.M.2    Woods, S.C.3    Benoit, S.C.4
  • 84
    • 84924699781 scopus 로고    scopus 로고
    • Sex and sex steroids: Impact on the kinetics of fatty acids underlying body shape
    • Santosa S, Jensen MD. Sex and sex steroids: impact on the kinetics of fatty acids underlying body shape. Horm Mol Biol Clin Investig 2014; 20: 15-23.
    • (2014) Horm Mol Biol Clin Investig , vol.20 , pp. 15-23
    • Santosa, S.1    Jensen, M.D.2
  • 87
    • 0036614916 scopus 로고    scopus 로고
    • Fat distribution and insulin sensitivity in postmenopausal women: Influence of hormone replacement
    • Munoz J, Derstine A, Gower BA. Fat distribution and insulin sensitivity in postmenopausal women: influence of hormone replacement. Obes Res 2002; 10: 424-31.
    • (2002) Obes Res , vol.10 , pp. 424-431
    • Munoz, J.1    Derstine, A.2    Gower, B.A.3
  • 88
    • 0041317787 scopus 로고    scopus 로고
    • Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution
    • Okura T, Koda M, Ando F, Niino N, Ohta S, Shimokata H. Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution. Int J Obes Relat Metab Disord 2003; 27: 1020-7.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 1020-1027
    • Okura, T.1    Koda, M.2    Ando, F.3    Niino, N.4    Ohta, S.5    Shimokata, H.6
  • 89
    • 84907210054 scopus 로고    scopus 로고
    • Effects of estrogen on food intake, serum leptin levels and leptin mRNA expression in adipose tissue of female rats
    • Fungfuang W, Terada M, Komatsu N, Moon C, Saito TR. Effects of estrogen on food intake, serum leptin levels and leptin mRNA expression in adipose tissue of female rats. Lab Anim Res 2013; 29: 168-73.
    • (2013) Lab Anim Res , vol.29 , pp. 168-173
    • Fungfuang, W.1    Terada, M.2    Komatsu, N.3    Moon, C.4    Saito, T.R.5
  • 90
    • 84878632677 scopus 로고    scopus 로고
    • The role of estrogens in control of energy balance and glucose homeostasis
    • Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev 2013; 34: 309-38.
    • (2013) Endocr Rev , vol.34 , pp. 309-338
    • Mauvais-Jarvis, F.1    Clegg, D.J.2    Hevener, A.L.3
  • 91
    • 84866942785 scopus 로고    scopus 로고
    • Metabolic dysfunction under reduced estrogen levels: Looking to exercise for prevention
    • Spangenburg EE, Wohlers LM, Valencia AP. Metabolic dysfunction under reduced estrogen levels: looking to exercise for prevention. Exerc Sport Sci Rev 2012; 40: 195-203.
    • (2012) Exerc Sport Sci Rev , vol.40 , pp. 195-203
    • Spangenburg, E.E.1    Wohlers, L.M.2    Valencia, A.P.3
  • 93
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 2007; 282: 743-51.
    • (2007) J Biol Chem , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 96
    • 67650561454 scopus 로고    scopus 로고
    • Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice
    • Grefhorst A, Parks EJ. Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice. J Lipid Res 2009; 50: 1374-83.
    • (2009) J Lipid Res , vol.50 , pp. 1374-1383
    • Grefhorst, A.1    Parks, E.J.2
  • 97
    • 73449114562 scopus 로고    scopus 로고
    • Differential effects of activation of liver X receptor on plasma lipid homeostasis in wild-type and lipoprotein clearance-deficient mice
    • Peng D, Hiipakka RA, Xie JT, Reardon CA, Getz GS, Liao S. Differential effects of activation of liver X receptor on plasma lipid homeostasis in wild-type and lipoprotein clearance-deficient mice. Atherosclerosis 2010; 208: 126-33.
    • (2010) Atherosclerosis , vol.208 , pp. 126-133
    • Peng, D.1    Hiipakka, R.A.2    Xie, J.T.3    Reardon, C.A.4    Getz, G.S.5    Liao, S.6
  • 98
    • 79960241384 scopus 로고    scopus 로고
    • PPARalpha-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
    • Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC. PPARalpha-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status. Biochem J 2011; 437: 521-30.
    • (2011) Biochem J , vol.437 , pp. 521-530
    • Caton, P.W.1    Holness, M.J.2    Bishop-Bailey, D.3    Sugden, M.C.4
  • 99
    • 79251630019 scopus 로고    scopus 로고
    • LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats
    • Baranowski M, Zabielski P, Blachnio-Zabielska AU, Harasiuk D, Gorski J. LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats. Acta Physiol 2011; 201: 373-9.
    • (2011) Acta Physiol , vol.201 , pp. 373-379
    • Baranowski, M.1    Zabielski, P.2    Blachnio-Zabielska, A.U.3    Harasiuk, D.4    Gorski, J.5
  • 101
    • 84881578700 scopus 로고    scopus 로고
    • Liver X receptor agonist T0901317 enhanced peroxisome proliferator-activated receptor-delta expression and fatty acid oxidation in rat skeletal muscle
    • Baranowski M, Blachnio-Zabielska AU, Zabielski P, Harasim E, Harasiuk D, Chabowski A, Gorski J. Liver X receptor agonist T0901317 enhanced peroxisome proliferator-activated receptor-delta expression and fatty acid oxidation in rat skeletal muscle. J Physiol Pharmacol 2013; 64: 289-97.
    • (2013) J Physiol Pharmacol , vol.64 , pp. 289-297
    • Baranowski, M.1    Blachnio-Zabielska, A.U.2    Zabielski, P.3    Harasim, E.4    Harasiuk, D.5    Chabowski, A.6    Gorski, J.7
  • 103
    • 84878791042 scopus 로고    scopus 로고
    • Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice
    • Gao M, Bu L, Ma Y, Liu D. Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. PloS one 2013; 8: e65641.
    • (2013) PloS One , vol.8 , pp. e65641
    • Gao, M.1    Bu, L.2    Ma, Y.3    Liu, D.4


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