Extract of Kuding Tea Prevents High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice via Liver X Receptor (LXR) β Antagonism

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Fan, Shengjie ^a   Zhang, Yu ^a   Hu, Na ^a   Sun, Qinhu ^a   Ding, Xiaobo ^a,b,c   Li, Guowen ^a   Zheng, Bin ^a   Gu, Ming ^a   Huang, Feisi ^a   Sun, Yin Qiang ^a   Zhou, Zhiqin ^b,c   Lu, Xiong ^a   Huang, Cheng ^a   Ji, Guang ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SOUTHWEST UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; FATTY ACID SYNTHASE; LIVER X RECEPTOR; LIVER X RECEPTOR BETA; MESSENGER RNA;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET THERAPY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; KUDING TEA; LIPID ANALYSIS; LIPID DIET; LIPID METABOLISM; LIPOGENESIS; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PROTEIN PHOSPHORYLATION; REPORTER GENE; SCANNING ELECTRON MICROSCOPY; TEA; WEIGHT GAIN;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CULTURE MEDIA; DIET, HIGH-FAT; ETHANOL; FEMALE; GENE EXPRESSION REGULATION; HYPERLIPIDEMIAS; LIGANDS; LIPOGENESIS; LIVER; METABOLIC DISEASES; MICE; MICE, INBRED C57BL; OBESITY; ORPHAN NUCLEAR RECEPTORS; PHYTOTHERAPY; PLANT EXTRACTS; TEA;

ILEX; MUS;

EID: 84870747675     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051007     Document Type: Article

References (50)

1. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, et al. (2011) National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377: 557-567.
2. Popovich NG, Wood OB (1997) Drug therapy for obesity: an update. J Am Pharm Assoc (Wash) NS37: 31-39, 56.
3. Visscher TL, Seidell JC, (2001) The public health impact of obesity. Ann Rev Public Health 22: 355-375.
4. Saltiel AR, Kahn CR, (2001) Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414: 799-806.
5. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, et al. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93: 693-704.
6. Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, et al. (2001) Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest 107: 565-573.
7. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, et al. (2002) Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99: 7604-7609.
8. Kratzer A, Buchebner M, Pfeifer T, Becker TM, Uray G, et al. (2009) Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. J Lipid Res 50: 312-326.
9. Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, et al. (2003) Activation of liver X receptor improves glucose tolerance through coordinated regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A 100: 5419-5424.
10. Song C, Hiipakka RA, Liao S, (2001) Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis. Steroids 66: 473-479.
11. Zhu F, Cai YZ, Sun M, Ke J, Lu D, et al. (2009) Comparison of major phenolic constituents and in vitro antioxidant activity of diverse Kudingcha genotypes from Ilex kudingcha, Ilex cornuta, and Ligustrum robustum. J Agric Food Chem 57: 6082-6089.
12. Wong IY, He ZD, Huang Y, Chen ZY, (2001) Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens. J Agric Food Chem 49: 3113-3119.
13. Kim JY, Jeong HY, Lee HK, Yoo JK, Bae K, et al. (2011) Protective effect of Ilex latifolia, a major component of "kudingcha". against transient focal ischemia-induced neuronal damage in rats. J Ethnopharmacol 133: 558-564.
14. Zheng J, Wang X, Li H, Gu Y, Tu P, et al. (2009) Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins. Clin Hemorheol Microcirc 42: 29-36.
15. Zheng J, Tang L, Xian XD, Zhou SX, Shi HM, et al. (2009) Inhibitory effects of triterpenoid saponins from the leaves of Ilex kudingcha on aggregated LDL-induced lipid deposition in macrophages. Planta Med 75: 1410-1414.
16. Huang C, Zhang Y, Gong Z, Sheng X, Li Z, et al. (2006) Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun 348: 571-578.
17. Gong Z, Huang C, Sheng X, Zhang Y, Li Q, et al. (2009) The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. Endocrinology 150: 104-113.
18. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, et al. (1995) 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83: 803-812.
19. Mitro N, Mak PA, Vargas L, Godio C, Hampton E, et al. (2007) The nuclear receptor LXR is a glucose sensor. Nature 445: 219-223.
20. Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, et al. (2004) LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 119: 299-309.
21. Chun TH, Inoue M, Morisaki H, Yamanaka I, Miyamoto Y, et al. (2010) Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes 59: 2484-2494.
22. Wu T, Cheng ZH, Liu HP, Li Y, Chou GX, et al. (2005) Liposoluble components from leaves of iles cornuta. Chin Pharm J 40: 1460-1462.
23. Ntambi JM, Young-Cheul K, (2000) Adipocyte differentiation and gene expression. J Nutr 130: 3122S-3126S.
24. Gerhold DL, Liu F, Jiang G, Li Z, Xu J, et al. (2002) Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists. Endocrinology 143: 2106-2118.
25. Gong H, Xie W, (2004) Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential. Expert Opin Ther Targets 8: 49-54.
26. Chinetti G, Zawadski C, Fruchart JC, Staels B, (2004) Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochem Biophys Res Commun 314: 151-158.
27. Edwards PA, Kennedy MA, Mak PA, (2002) LXRs: oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vascul Pharmacol 38: 249-256.
28. Liu A, Luo Y, Lin Y, (2002) A review of the study on kudingcha. Zhong Yao Cai 25: 148-150.
29. Wang S, Chen J, Liu X, Wang Q, (1994) Effects of kudingcha on lipid profiles in patients. Chin J Integr Med 11: 670-672.
30. Liu B, Xu H, (2005) Experiment and clinical study on broadleaf holly to lower down blood lipids level. Chin Nurs Res 19: 21-22.
31. Wang Q, Chen J, (1998) Effects of folk medicinal herb kudingcha on hypertension and cardiovascular disease. Chin J Ethnomed Ethnopharm 34: 12-14.
32. Huang Z, (1997) Kudingcha treatment for hypertension- 35 case reports. Chin J Inform Trad Chin Med 4: 25.
33. Flier JS, (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337-350.
34. Wang S, Noh SK, Koo SI, (2006) Green tea catechins inhibit pancreatic phospholipase A(2) and intestinal absorption of lipids in ovariectomized rats. J Nutr Biochem 17: 492-498.
35. Loest HB, Noh SK, Koo SI, (2002) Green tea extract inhibits the lymphatic absorption of cholesterol and alpha-tocopherol in ovariectomized rats. J Nutr 132: 1282-1288.
36. Koo SI, Noh SK, (2007) Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. J Nutr Biochem 18: 179-183.
37. Lewis GF, Carpentier A, Adeli K, Giacca A, (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23: 201-229.
38. Raz I, Eldor R, Cernea S, Shafrir E, (2005) Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res Rev 21: 3-14.
39. Kraegen EW, Cooney GJ, Ye J, Thompson AL, (2001) Triglycerides, fatty acids and insulin resistance-hyperinsulinemia. Exp Clin Endocrinol Diabetes 109: S516-526.
40. Jia Y, Bhuiyan MJ, Jun HJ, Lee JH, Hoang MH, et al. (2011) Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism. Bioorg Med Chem Lett 21: 5876-5880.
41. Rao VS, Melo CL, Queiroz MG, Lemos TL, Menezes DB, et al. (2011) Ursolic Acid, A Pentacyclic Triterpene from Sambucus australis, Prevents Abdominal Adiposity in Mice Fed a High-Fat Diet. J Med Food 14: 1375-1382.
42. Azevedo MF, Camsari C, Sa CM, Lima CF, Fernandes-Ferreira M, et al. (2010) Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. Phytother Res 24Suppl 2: S220-224.
43. Kim J, Jang DS, Kim H, Kim JS, (2009) Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta. Arch Pharm Res 32: 983-987.
44. Gupta R, Sharma AK, Sharma MC, Dobhal MP, Gupta RS, (2011) Evaluation of anti-diabetic and antioxidant potential of lupeol in experimental hyperglycaemia. Nat Prod Res 26: 1125-1129.
45. Papi Reddy K, Singh AB, Puri A, Srivastava AK, Narender T, (2009) Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity. Bioorg Med Chem Lett 19: 4463-4466.
46. Niesor EJ, Flach J, Lopes-Antoni I, Perez A, Bentzen CL, (2001) The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases. Curr Pharm Des 7: 231-259.
47. Lund EG, Menke JG, Sparrow CP, (2003) Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol 23: 1169-1177.
48. Sheng X, Wang M, Lu M, Xi B, Sheng H, et al. (2011) Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice. Am J Physiol Endocrinol Metab 300: E886-893.
49. Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, et al. (2010) Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One 5: e12399.
50. Kanaya N, Kubo M, Liu Z, Chu P, Wang C, et al. (2011) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. PLoS One 6: e26654.