A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα

Biochimie

Volumn 95, Issue 3, 2013, Pages 556-567

  Ducheix, Simon ^a   Podechard, Normand ^a,b   Lasserre, Frédéric ^a   Polizzi, Arnaud ^a   Pommier, Aurélien ^c   Murzilli, Stefania ^d   Di Lisio, Chiara ^d   D'Amore, Simona ^d   Bertrand Michel, Justine ^e   Montagner, Alexandra ^a   Pineau, Thierry ^a   Loiseau, Nicolas ^a   Lobaccaro, Jean Marc ^c   Martin, Pascal G P ^a   Guillou, Hervé ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b UFR Pharmacie   (France)

^c CRNH AUVERGNE   (France)

^d Laboratory of Lipid Metabolism and Cancer   (Italy)

^e CHU PURPAN   (France)

Author keywords

Lipogenesis; LXR; Oxysterol; PPAR ; Steatosis

Indexed keywords

CYTOCHROME P450 4A; CYTOCHROME P450 4A10; CYTOCHROME P450 4A14; FENOFIBRATE; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXYSTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE CONTROL; GENE FUNCTION; GENE OVEREXPRESSION; GENOTYPE; HYDROXYLATION; LIPOGENESIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS; FENOFIBRATE; HYDROCARBONS, FLUORINATED; LIGANDS; LIPOGENESIS; LIVER; MALE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORPHAN NUCLEAR RECEPTORS; PPAR ALPHA; PROTEIN ISOFORMS; RECEPTOR CROSS-TALK; SULFONAMIDES; SYSTEMS BIOLOGY; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 84874112449     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.09.028     Document Type: Article

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