메뉴 건너뛰기




Volumn 11, Issue 6, 2015, Pages

Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CYCLIC AMP; CYCLIC GMP; EFAVIRENZ; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN; RALTEGRAVIR; SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 84936741267     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004930     Document Type: Article
Times cited : (67)

References (70)
  • 1
    • 73549099347 scopus 로고    scopus 로고
    • Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?
    • Blankson JN, (2010) Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses? Antiviral Res 85: 295–302. doi: 10.1016/j.antiviral.2009.08.007 19733595
    • (2010) Antiviral Res , vol.85 , pp. 295-302
    • Blankson, J.N.1
  • 2
    • 65449126294 scopus 로고    scopus 로고
    • Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control
    • Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, et al. (2009) Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control. Blood 113: 3978–3989. doi: 10.1182/blood-2008-10-182709 19109229
    • (2009) Blood , vol.113 , pp. 3978-3989
    • Ferre, A.L.1    Hunt, P.W.2    Critchfield, J.W.3    Young, D.H.4    Morris, M.M.5
  • 3
    • 79953815120 scopus 로고    scopus 로고
    • Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression
    • Hersperger AR, Martin JN, Shin LY, Sheth PM, Kovacs CM, et al. (2011) Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression. Blood 117: 3799–3808. doi: 10.1182/blood-2010-12-322727 21289310
    • (2011) Blood , vol.117 , pp. 3799-3808
    • Hersperger, A.R.1    Martin, J.N.2    Shin, L.Y.3    Sheth, P.M.4    Kovacs, C.M.5
  • 4
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • Saez-Cirion A, Lacabaratz C, Lambotte O, Versmisse P, Urrutia A, et al. (2007) HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc Natl Acad Sci U S A 104: 6776–6781. 17428922
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6776-6781
    • Saez-Cirion, A.1    Lacabaratz, C.2    Lambotte, O.3    Versmisse, P.4    Urrutia, A.5
  • 5
    • 16544383331 scopus 로고    scopus 로고
    • Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
    • Hugues S, Fetler L, Bonifaz L, Helft J, Amblard F, et al. (2004) Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nat Immunol 5: 1235–1242. 15516925
    • (2004) Nat Immunol , vol.5 , pp. 1235-1242
    • Hugues, S.1    Fetler, L.2    Bonifaz, L.3    Helft, J.4    Amblard, F.5
  • 6
    • 58049209834 scopus 로고    scopus 로고
    • Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    • Joffre O, Nolte MA, Sporri R, Reis e Sousa C, (2009) Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol Rev 227: 234–247. doi: 10.1111/j.1600-065X.2008.00718.x 19120488
    • (2009) Immunol Rev , vol.227 , pp. 234-247
    • Joffre, O.1    Nolte, M.A.2    Sporri, R.3    Reis e Sousa, C.4
  • 8
    • 78650199162 scopus 로고    scopus 로고
    • Dendritic cells and immunity against cancer
    • Palucka K, Ueno H, Fay J, Banchereau J, (2011) Dendritic cells and immunity against cancer. J Intern Med 269: 64–73. doi: 10.1111/j.1365-2796.2010.02317.x 21158979
    • (2011) J Intern Med , vol.269 , pp. 64-73
    • Palucka, K.1    Ueno, H.2    Fay, J.3    Banchereau, J.4
  • 9
    • 77349101042 scopus 로고    scopus 로고
    • Features of the dendritic cell lineage
    • Steinman RM, Idoyaga J, (2010) Features of the dendritic cell lineage. Immunol Rev 234: 5–17. doi: 10.1111/j.0105-2896.2009.00888.x 20193008
    • (2010) Immunol Rev , vol.234 , pp. 5-17
    • Steinman, R.M.1    Idoyaga, J.2
  • 10
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM, (1998) Dendritic cells and the control of immunity. Nature 392: 245–252. 9521319
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 11
    • 58049200734 scopus 로고    scopus 로고
    • Innate immunity to pathogens: diversity in receptors for microbial recognition
    • Akira S, (2009) Innate immunity to pathogens: diversity in receptors for microbial recognition. Immunol Rev 227: 5–8. doi: 10.1111/j.1600-065X.2008.00739.x 19120470
    • (2009) Immunol Rev , vol.227 , pp. 5-8
    • Akira, S.1
  • 12
    • 34548694962 scopus 로고    scopus 로고
    • Innate recognition of viruses
    • Pichlmair A, Reis e Sousa C, (2007) Innate recognition of viruses. Immunity 27: 370–383. 17892846
    • (2007) Immunity , vol.27 , pp. 370-383
    • Pichlmair, A.1    Reis e Sousa, C.2
  • 13
    • 67650445798 scopus 로고    scopus 로고
    • Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    • Longhi MP, Trumpfheller C, Idoyaga J, Caskey M, Matos I, et al. (2009) Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med 206: 1589–1602. doi: 10.1084/jem.20090247 19564349
    • (2009) J Exp Med , vol.206 , pp. 1589-1602
    • Longhi, M.P.1    Trumpfheller, C.2    Idoyaga, J.3    Caskey, M.4    Matos, I.5
  • 14
    • 0026097442 scopus 로고
    • HIV-1 infection does not induce tumor necrosis factor-alpha or interferon-beta gene transcription
    • Goldfeld AE, Birch-Limberger K, Schooley RT, Walker BD, (1991) HIV-1 infection does not induce tumor necrosis factor-alpha or interferon-beta gene transcription. J Acquir Immune Defic Syndr 4: 41–47. 1845771
    • (1991) J Acquir Immune Defic Syndr , vol.4 , pp. 41-47
    • Goldfeld, A.E.1    Birch-Limberger, K.2    Schooley, R.T.3    Walker, B.D.4
  • 15
    • 0033763707 scopus 로고    scopus 로고
    • Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells
    • Negre D, Mangeot PE, Duisit G, Blanchard S, Vidalain PO, et al. (2000) Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells. Gene Ther 7: 1613–1623. 11083469
    • (2000) Gene Ther , vol.7 , pp. 1613-1623
    • Negre, D.1    Mangeot, P.E.2    Duisit, G.3    Blanchard, S.4    Vidalain, P.O.5
  • 16
    • 77956497003 scopus 로고    scopus 로고
    • A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    • Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, et al. (2010) A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 467: 214–217. doi: 10.1038/nature09337 20829794
    • (2010) Nature , vol.467 , pp. 214-217
    • Manel, N.1    Hogstad, B.2    Wang, Y.3    Levy, D.E.4    Unutmaz, D.5
  • 17
    • 80054697388 scopus 로고    scopus 로고
    • Hiding in plain sight: how HIV evades innate immune responses
    • Manel N, Littman DR, (2011) Hiding in plain sight: how HIV evades innate immune responses. Cell 147: 271–274. doi: 10.1016/j.cell.2011.09.010 22000008
    • (2011) Cell , vol.147 , pp. 271-274
    • Manel, N.1    Littman, D.R.2
  • 18
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J, (2010) The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 11: 1005–1013. doi: 10.1038/ni.1941 20871604
    • (2010) Nat Immunol , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3    Lee-Kirsch, M.A.4    Lieberman, J.5
  • 19
    • 83555164881 scopus 로고    scopus 로고
    • HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
    • Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, et al. (2011) HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480: 379–382. doi: 10.1038/nature10623 22056990
    • (2011) Nature , vol.480 , pp. 379-382
    • Goldstone, D.C.1    Ennis-Adeniran, V.2    Hedden, J.J.3    Groom, H.C.4    Rice, G.I.5
  • 20
    • 79959858243 scopus 로고    scopus 로고
    • Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
    • Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, et al. (2011) Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474: 658–661. doi: 10.1038/nature10195 21720370
    • (2011) Nature , vol.474 , pp. 658-661
    • Hrecka, K.1    Hao, C.2    Gierszewska, M.3    Swanson, S.K.4    Kesik-Brodacka, M.5
  • 21
    • 79959843617 scopus 로고    scopus 로고
    • SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    • Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, et al. (2011) SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474: 654–657. doi: 10.1038/nature10117 21613998
    • (2011) Nature , vol.474 , pp. 654-657
    • Laguette, N.1    Sobhian, B.2    Casartelli, N.3    Ringeard, M.4    Chable-Bessia, C.5
  • 22
    • 80051792497 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells
    • Sunseri N, O'Brien M, Bhardwaj N, Landau NR, (2011) Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells. J Virol 85: 6263–6274. doi: 10.1128/JVI.00346-11 21507971
    • (2011) J Virol , vol.85 , pp. 6263-6274
    • Sunseri, N.1    O'Brien, M.2    Bhardwaj, N.3    Landau, N.R.4
  • 23
    • 84905732218 scopus 로고    scopus 로고
    • The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
    • Ryoo J, Choi J, Oh C, Kim S, Seo M, et al. (2014) The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med 20: 936–941. doi: 10.1038/nm.3626 25038827
    • (2014) Nat Med , vol.20 , pp. 936-941
    • Ryoo, J.1    Choi, J.2    Oh, C.3    Kim, S.4    Seo, M.5
  • 24
    • 84893934506 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA by cGAS and other STING-dependent sensors
    • Bhat N, Fitzgerald KA, (2014) Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur J Immunol 44: 634–640. doi: 10.1002/eji.201344127 24356864
    • (2014) Eur J Immunol , vol.44 , pp. 634-640
    • Bhat, N.1    Fitzgerald, K.A.2
  • 25
    • 84891702580 scopus 로고    scopus 로고
    • Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade
    • Lam E, Stein S, Falck-Pedersen E, (2014) Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol 88: 974–981. doi: 10.1128/JVI.02702-13 24198409
    • (2014) J Virol , vol.88 , pp. 974-981
    • Lam, E.1    Stein, S.2    Falck-Pedersen, E.3
  • 26
    • 84888002403 scopus 로고    scopus 로고
    • IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    • Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, et al. (2013) IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc Natl Acad Sci U S A 110: E4571–4580. doi: 10.1073/pnas.1311669110 24154727
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E4571-4580
    • Jakobsen, M.R.1    Bak, R.O.2    Andersen, A.3    Berg, R.K.4    Jensen, S.B.5
  • 27
    • 84890215093 scopus 로고    scopus 로고
    • The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells
    • Lahaye X, Satoh T, Gentili M, Cerboni S, Conrad C, et al. (2013) The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity 39: 1132–1142. doi: 10.1016/j.immuni.2013.11.002 24269171
    • (2013) Immunity , vol.39 , pp. 1132-1142
    • Lahaye, X.1    Satoh, T.2    Gentili, M.3    Cerboni, S.4    Conrad, C.5
  • 28
    • 84855333779 scopus 로고    scopus 로고
    • How SAMHD1 changes our view of viral restriction
    • Laguette N, Benkirane M, (2012) How SAMHD1 changes our view of viral restriction. Trends Immunol 33: 26–33. doi: 10.1016/j.it.2011.11.002 22177690
    • (2012) Trends Immunol , vol.33 , pp. 26-33
    • Laguette, N.1    Benkirane, M.2
  • 29
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R, (2008) Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134: 587–598. doi: 10.1016/j.cell.2008.06.032 18724932
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 30
    • 79952408305 scopus 로고    scopus 로고
    • Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers
    • Vigneault F, Woods M, Buzon MJ, Li C, Pereyra F, et al. (2011) Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers. J Virol 85: 3015–3019. doi: 10.1128/JVI.01846-10 21177805
    • (2011) J Virol , vol.85 , pp. 3015-3019
    • Vigneault, F.1    Woods, M.2    Buzon, M.J.3    Li, C.4    Pereyra, F.5
  • 31
    • 33847219326 scopus 로고    scopus 로고
    • Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes
    • Cameron PU, Handley AJ, Baylis DC, Solomon AE, Bernard N, et al. (2007) Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes. J Virol 81: 2297–2306. 17166903
    • (2007) J Virol , vol.81 , pp. 2297-2306
    • Cameron, P.U.1    Handley, A.J.2    Baylis, D.C.3    Solomon, A.E.4    Bernard, N.5
  • 32
    • 30744448648 scopus 로고    scopus 로고
    • HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood
    • Granelli-Piperno A, Shimeliovich I, Pack M, Trumpfheller C, Steinman RM, (2006) HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood. J Immunol 176: 991–998. 16393985
    • (2006) J Immunol , vol.176 , pp. 991-998
    • Granelli-Piperno, A.1    Shimeliovich, I.2    Pack, M.3    Trumpfheller, C.4    Steinman, R.M.5
  • 33
    • 21644483118 scopus 로고    scopus 로고
    • Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells
    • Smed-Sorensen A, Lore K, Vasudevan J, Louder MK, Andersson J, et al. (2005) Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol 79: 8861–8869. 15994779
    • (2005) J Virol , vol.79 , pp. 8861-8869
    • Smed-Sorensen, A.1    Lore, K.2    Vasudevan, J.3    Louder, M.K.4    Andersson, J.5
  • 34
    • 42949114952 scopus 로고    scopus 로고
    • The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
    • Engelman A, Cherepanov P, (2008) The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog 4: e1000046. doi: 10.1371/journal.ppat.1000046 18369482
    • (2008) PLoS Pathog , vol.4 , pp. e1000046
    • Engelman, A.1    Cherepanov, P.2
  • 35
    • 77955922760 scopus 로고    scopus 로고
    • Transportin 3 and importin alpha are required for effective nuclear import of HIV-1 integrase in virus-infected cells
    • Levin A, Hayouka Z, Friedler A, Loyter A, (2010) Transportin 3 and importin alpha are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus 1: 422–431. doi: 10.4161/nucl.1.5.12903 21326825
    • (2010) Nucleus , vol.1 , pp. 422-431
    • Levin, A.1    Hayouka, Z.2    Friedler, A.3    Loyter, A.4
  • 36
    • 73949140662 scopus 로고    scopus 로고
    • Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins
    • Levin A, Rosenbluh J, Hayouka Z, Friedler A, Loyter A, (2010) Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins. Mol Med 16: 34–44. doi: 10.2119/molmed.2009.00133 19855849
    • (2010) Mol Med , vol.16 , pp. 34-44
    • Levin, A.1    Rosenbluh, J.2    Hayouka, Z.3    Friedler, A.4    Loyter, A.5
  • 37
    • 39349097864 scopus 로고    scopus 로고
    • Identification of host proteins required for HIV infection through a functional genomic screen
    • Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, et al. (2008) Identification of host proteins required for HIV infection through a functional genomic screen. Science 319: 921–926. doi: 10.1126/science.1152725 18187620
    • (2008) Science , vol.319 , pp. 921-926
    • Brass, A.L.1    Dykxhoorn, D.M.2    Benita, Y.3    Yan, N.4    Engelman, A.5
  • 38
    • 52949130695 scopus 로고    scopus 로고
    • Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication
    • Konig R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, et al. (2008) Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135: 49–60. doi: 10.1016/j.cell.2008.07.032 18854154
    • (2008) Cell , vol.135 , pp. 49-60
    • Konig, R.1    Zhou, Y.2    Elleder, D.3    Diamond, T.L.4    Bonamy, G.M.5
  • 39
    • 28644443483 scopus 로고    scopus 로고
    • A role for LEDGF/p75 in targeting HIV DNA integration
    • Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, et al. (2005) A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med 11: 1287–1289. 16311605
    • (2005) Nat Med , vol.11 , pp. 1287-1289
    • Ciuffi, A.1    Llano, M.2    Poeschla, E.3    Hoffmann, C.4    Leipzig, J.5
  • 40
    • 33750358735 scopus 로고    scopus 로고
    • An essential role for LEDGF/p75 in HIV integration
    • Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, et al. (2006) An essential role for LEDGF/p75 in HIV integration. Science 314: 461–464. 16959972
    • (2006) Science , vol.314 , pp. 461-464
    • Llano, M.1    Saenz, D.T.2    Meehan, A.3    Wongthida, P.4    Peretz, M.5
  • 41
    • 84878572947 scopus 로고    scopus 로고
    • The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
    • Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, et al. (2013) The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep 3: 1355–1361. doi: 10.1016/j.celrep.2013.05.009 23707065
    • (2013) Cell Rep , vol.3 , pp. 1355-1361
    • Diner, E.J.1    Burdette, D.L.2    Wilson, S.C.3    Monroe, K.M.4    Kellenberger, C.A.5
  • 42
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao D, Wu J, Wu YT, Du F, Aroh C, et al. (2013) Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341: 903–906. doi: 10.1126/science.1240933 23929945
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1    Wu, J.2    Wu, Y.T.3    Du, F.4    Aroh, C.5
  • 43
    • 84879385334 scopus 로고    scopus 로고
    • cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, et al. (2013) cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498: 380–384. doi: 10.1038/nature12306 23722158
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1    Goldeck, M.2    Cavlar, T.3    Deimling, T.4    Witte, G.5
  • 44
    • 79956007831 scopus 로고    scopus 로고
    • Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts
    • Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, et al. (2011) Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res 9: 589–602. doi: 10.1158/1541-7786.MCR-10-0565 21471287
    • (2011) Mol Cancer Res , vol.9 , pp. 589-602
    • Duan, X.1    Ponomareva, L.2    Veeranki, S.3    Panchanathan, R.4    Dickerson, E.5
  • 45
    • 84892946076 scopus 로고    scopus 로고
    • IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
    • Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, et al. (2014) IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 343: 428–432. doi: 10.1126/science.1243640 24356113
    • (2014) Science , vol.343 , pp. 428-432
    • Monroe, K.M.1    Yang, Z.2    Johnson, J.R.3    Geng, X.4    Doitsh, G.5
  • 46
    • 84655165036 scopus 로고    scopus 로고
    • Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization
    • Veeranki S, Choubey D, (2012) Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization. Mol Immunol 49: 567–571. doi: 10.1016/j.molimm.2011.11.004 22137500
    • (2012) Mol Immunol , vol.49 , pp. 567-571
    • Veeranki, S.1    Choubey, D.2
  • 47
    • 40149106131 scopus 로고    scopus 로고
    • Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity
    • Joseph A, Zheng JH, Follenzi A, Dilorenzo T, Sango K, et al. (2008) Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity. J Virol 82: 3078–3089. doi: 10.1128/JVI.01812-07 18184707
    • (2008) J Virol , vol.82 , pp. 3078-3089
    • Joseph, A.1    Zheng, J.H.2    Follenzi, A.3    Dilorenzo, T.4    Sango, K.5
  • 48
    • 79957998255 scopus 로고    scopus 로고
    • HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production
    • Harman AN, Lai J, Turville S, Samarajiwa S, Gray L, et al. (2011) HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. Blood 118: 298–308. doi: 10.1182/blood-2010-07-297721 21411754
    • (2011) Blood , vol.118 , pp. 298-308
    • Harman, A.N.1    Lai, J.2    Turville, S.3    Samarajiwa, S.4    Gray, L.5
  • 49
    • 84888054227 scopus 로고    scopus 로고
    • HIV-1 evades innate immune recognition through specific cofactor recruitment
    • Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, et al. (2013) HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature 503: 402–405. doi: 10.1038/nature12769 24196705
    • (2013) Nature , vol.503 , pp. 402-405
    • Rasaiyaah, J.1    Tan, C.P.2    Fletcher, A.J.3    Price, A.J.4    Blondeau, C.5
  • 50
    • 84865106370 scopus 로고    scopus 로고
    • Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism
    • Doehle BP, Chang K, Rustagi A, McNevin J, McElrath MJ, et al. (2012) Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism. J Virol 86: 8367–8374. doi: 10.1128/JVI.00423-12 22593165
    • (2012) J Virol , vol.86 , pp. 8367-8374
    • Doehle, B.P.1    Chang, K.2    Rustagi, A.3    McNevin, J.4    McElrath, M.J.5
  • 51
    • 84857333841 scopus 로고    scopus 로고
    • Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein
    • Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Munch J, et al. (2012) Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host Microbe 11: 205–217. doi: 10.1016/j.chom.2012.01.007 22305291
    • (2012) Cell Host Microbe , vol.11 , pp. 205-217
    • Laguette, N.1    Rahm, N.2    Sobhian, B.3    Chable-Bessia, C.4    Munch, J.5
  • 52
    • 84897553271 scopus 로고    scopus 로고
    • Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cells
    • Su B, Biedma ME, Lederle A, Peressin M, Lambotin M, et al. (2014) Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cells. J Virol 88: 5109–5121. doi: 10.1128/JVI.03057-13 24574390
    • (2014) J Virol , vol.88 , pp. 5109-5121
    • Su, B.1    Biedma, M.E.2    Lederle, A.3    Peressin, M.4    Lambotin, M.5
  • 53
    • 84880231858 scopus 로고    scopus 로고
    • APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure
    • Holtz CM, Sadler HA, Mansky LM, (2013) APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure. Nucleic Acids Res 41: 6139–6148. doi: 10.1093/nar/gkt246 23620282
    • (2013) Nucleic Acids Res , vol.41 , pp. 6139-6148
    • Holtz, C.M.1    Sadler, H.A.2    Mansky, L.M.3
  • 54
    • 80052498633 scopus 로고    scopus 로고
    • Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers
    • Buzon MJ, Seiss K, Weiss R, Brass AL, Rosenberg ES, et al. (2011) Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers. J Virol 85: 9646–9650. doi: 10.1128/JVI.05327-11 21734042
    • (2011) J Virol , vol.85 , pp. 9646-9650
    • Buzon, M.J.1    Seiss, K.2    Weiss, R.3    Brass, A.L.4    Rosenberg, E.S.5
  • 55
    • 84888637695 scopus 로고    scopus 로고
    • Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
    • Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, et al. (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503: 530–534. doi: 10.1038/nature12640 24077100
    • (2013) Nature , vol.503 , pp. 530-534
    • Ablasser, A.1    Schmid-Burgk, J.L.2    Hemmerling, I.3    Horvath, G.L.4    Schmidt, T.5
  • 56
    • 84879408976 scopus 로고    scopus 로고
    • Structural mechanism of cytosolic DNA sensing by cGAS
    • Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, et al. (2013) Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498: 332–337. doi: 10.1038/nature12305 23722159
    • (2013) Nature , vol.498 , pp. 332-337
    • Civril, F.1    Deimling, T.2    de Oliveira Mann, C.C.3    Ablasser, A.4    Moldt, M.5
  • 57
    • 84882815198 scopus 로고    scopus 로고
    • Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
    • Gao P, Ascano M, Zillinger T, Wang W, Dai P, et al. (2013) Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 154: 748–762. doi: 10.1016/j.cell.2013.07.023 23910378
    • (2013) Cell , vol.154 , pp. 748-762
    • Gao, P.1    Ascano, M.2    Zillinger, T.3    Wang, W.4    Dai, P.5
  • 58
    • 40049094957 scopus 로고    scopus 로고
    • Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    • Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, et al. (2008) Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis 197: 563–571. doi: 10.1086/526786 18275276
    • (2008) J Infect Dis , vol.197 , pp. 563-571
    • Pereyra, F.1    Addo, M.M.2    Kaufmann, D.E.3    Liu, Y.4    Miura, T.5
  • 59
    • 84898856258 scopus 로고    scopus 로고
    • HIV "elite controllers" are characterized by a high frequency of memory CD8+ CD73+ T cells involved in the antigen-specific CD8+ T-cell response
    • Carriere M, Lacabaratz C, Kok A, Benne C, Jenabian MA, et al. (2014) HIV "elite controllers" are characterized by a high frequency of memory CD8+ CD73+ T cells involved in the antigen-specific CD8+ T-cell response. J Infect Dis 209: 1321–1330. doi: 10.1093/infdis/jit643 24357632
    • (2014) J Infect Dis , vol.209 , pp. 1321-1330
    • Carriere, M.1    Lacabaratz, C.2    Kok, A.3    Benne, C.4    Jenabian, M.A.5
  • 60
    • 84868675469 scopus 로고    scopus 로고
    • Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression
    • Brennan CA, Ibarrondo FJ, Sugar CA, Hausner MA, Shih R, et al. (2012) Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression. J Virol 86: 10505–10516. doi: 10.1128/JVI.00102-12 22811521
    • (2012) J Virol , vol.86 , pp. 10505-10516
    • Brennan, C.A.1    Ibarrondo, F.J.2    Sugar, C.A.3    Hausner, M.A.4    Shih, R.5
  • 61
    • 84873542088 scopus 로고    scopus 로고
    • High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control
    • Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, et al. (2013) High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. Blood 121: 801–811. doi: 10.1182/blood-2012-06-436295 23233659
    • (2013) Blood , vol.121 , pp. 801-811
    • Ndhlovu, Z.M.1    Chibnik, L.B.2    Proudfoot, J.3    Vine, S.4    McMullen, A.5
  • 62
    • 77956033397 scopus 로고    scopus 로고
    • Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
    • Huang J, Burke PS, Cung TD, Pereyra F, Toth I, et al. (2010) Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J Virol 84: 9463–9471. doi: 10.1128/JVI.01009-10 20631139
    • (2010) J Virol , vol.84 , pp. 9463-9471
    • Huang, J.1    Burke, P.S.2    Cung, T.D.3    Pereyra, F.4    Toth, I.5
  • 63
    • 69949153012 scopus 로고    scopus 로고
    • Immune activation and antibody responses in non-progressing elite controller individuals infected with HIV-1
    • Bello G, Velasco-de-Castro CA, Bongertz V, Rodrigues CA, Giacoia-Gripp CB, et al. (2009) Immune activation and antibody responses in non-progressing elite controller individuals infected with HIV-1. J Med Virol 81: 1681–1690. doi: 10.1002/jmv.21565 19697415
    • (2009) J Med Virol , vol.81 , pp. 1681-1690
    • Bello, G.1    Velasco-de-Castro, C.A.2    Bongertz, V.3    Rodrigues, C.A.4    Giacoia-Gripp, C.B.5
  • 64
    • 84870251319 scopus 로고    scopus 로고
    • Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers
    • Pereyra F, Lo J, Triant VA, Wei J, Buzon MJ, et al. (2012) Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS 26: 2409–2412. doi: 10.1097/QAD.0b013e32835a9950 23032411
    • (2012) AIDS , vol.26 , pp. 2409-2412
    • Pereyra, F.1    Lo, J.2    Triant, V.A.3    Wei, J.4    Buzon, M.J.5
  • 65
    • 79953305839 scopus 로고    scopus 로고
    • CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
    • Chen H, Li C, Huang J, Cung T, Seiss K, et al. (2011) CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J Clin Invest 121: 1549–1560. doi: 10.1172/JCI44539 21403397
    • (2011) J Clin Invest , vol.121 , pp. 1549-1560
    • Chen, H.1    Li, C.2    Huang, J.3    Cung, T.4    Seiss, K.5
  • 66
    • 0033532628 scopus 로고    scopus 로고
    • Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes
    • Unutmaz D, KewalRamani VN, Marmon S, Littman DR, (1999) Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J Exp Med 189: 1735–1746. 10359577
    • (1999) J Exp Med , vol.189 , pp. 1735-1746
    • Unutmaz, D.1    KewalRamani, V.N.2    Marmon, S.3    Littman, D.R.4
  • 67
    • 84897386464 scopus 로고    scopus 로고
    • LILRB2 interaction with HLA class I correlates with control of HIV-1 infection
    • Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, et al. (2014) LILRB2 interaction with HLA class I correlates with control of HIV-1 infection. PLoS Genet 10: e1004196. doi: 10.1371/journal.pgen.1004196 24603468
    • (2014) PLoS Genet , vol.10 , pp. e1004196
    • Bashirova, A.A.1    Martin-Gayo, E.2    Jones, D.C.3    Qi, Y.4    Apps, R.5
  • 68
    • 84893761231 scopus 로고    scopus 로고
    • HIV-1 persistence in CD4 T cells with stem cell-like properties
    • Buzon MJ, Sun H, Li C, Shaw A, Seiss K, et al. (2014) HIV-1 persistence in CD4 T cells with stem cell-like properties. Nat Med.
    • (2014) Nat Med
    • Buzon, M.J.1    Sun, H.2    Li, C.3    Shaw, A.4    Seiss, K.5
  • 69
    • 0141457701 scopus 로고    scopus 로고
    • Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus
    • Brussel A, Sonigo P, (2003) Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus. J Virol 77: 10119–10124. 12941923
    • (2003) J Virol , vol.77 , pp. 10119-10124
    • Brussel, A.1    Sonigo, P.2
  • 70
    • 60549111634 scopus 로고    scopus 로고
    • WGCNA: an R package for weighted correlation network analysis
    • Langfelder P, Horvath S, (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9: 559. doi: 10.1186/1471-2105-9-559 19114008
    • (2008) BMC Bioinformatics , vol.9 , pp. 559
    • Langfelder, P.1    Horvath, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.