High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

Blood

Volumn 121, Issue 5, 2013, Pages 801-811

  Ndhlovu, Zaza M ^a,b   Chibnik, Lori B ^c   Proudfoot, Jacqueline ^a   Vine, Seanna ^a   McMullen, Ashley ^a   Cesa, Kevin ^a   Porichis, Filippos ^a   Jones, R Brad ^a   Alvino, Donna Marie ^a   Hart, Meghan G ^a   Stampouloglou, Eleni ^a   Piechocka Trocha, Alicja ^a   Kadie, Carl ^d   Pereyra, Florencia ^a   Heckerman, David ^d   De Jager, Philip L ^b,e   Walker, Bruce D ^a,f,g   Kaufmann, Daniel E ^a,g,h,i  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MICROSOFT RESEARCH   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

ⁱ UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Immune monitoring models integrating multiple functions of HIV 1 specific CD8 T cells distinguish controllers from subjects with progressive HIV 1 infection.; This strategy may have important applications in predictive model development and immune monitoring of HIV 1 vaccine trials

Indexed keywords

EPITOPE; VIRUS VACCINE;

ADULT; ALLELE; ARTICLE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; VALIDATION STUDY;

EID: 84873542088     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-06-436295     Document Type: Article

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