Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: Regulation of subcellular localization

Molecular Immunology

Volumn 49, Issue 4, 2012, Pages 567-571

  Veeranki, Sudhakar ^a   Choubey, Divaker ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

IFI16; IFN production; Inflammasome; Interferon; P200 Family proteins

Indexed keywords

DOUBLE STRANDED DNA; IFI16 PROTEIN; INFLAMMASOME; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL GROWTH; CYTOSOL; HORMONAL REGULATION; HUMAN; INNATE IMMUNITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; VIRUS RESISTANCE;

ANIMALS; CELL NUCLEUS; CYTOSOL; DNA; HUMANS; IMMUNITY, INNATE; INTERFERONS; NUCLEAR PROTEINS; PHOSPHOPROTEINS;

MURINAE;

EID: 84655165036     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.11.004     Document Type: Review

References (40)

1. Aglipay J.A., Lee S.W., Okada S., Fujiuchi N., Ohtsuka T., Kwak J.C., Wang Y., Johnstone R.W., Deng C., Qin J., Ouchi T. A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 2003, 22:8931-8938.
2. Albrecht M., Choubey D., Lengauer T. The HIN domain of IFI-200 proteins consists of two OB folds. Biochem. Biophys. Res. Commun. 2005, 327:679-687.
3. Alimirah F., Chen J., Xin H., Choubey D. Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein. FEBS Lett. 2006, 580:1659-1664.
4. Asefa B., Klarmann K.D., Copeland N.G., Gilbert D.J., Jenkins N.A., Keller J.R. The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation. Blood Cells. Mol. Dis. 2004, 32:155-167.
5. Barbe L., Lundberg E., Oksvold P., Stenius A., Lewin E., Bjorling E., Asplund A., Ponten F., Brismar H., Uhlen M., Andersson-Svahn H. Toward a confocal subcellular atlas of the human proteome. Mol. Cell. Proteomics 2008, 7:499-508.
6. Berry A., Matthews L., Jangani M., Plumb J., Farrow S., Buchan N., Wilson P.A., Singh D., Ray D.W., Donn R.P. Interferon-inducible factor 16 is a novel modulator of glucocorticoid action. FASEB J. 2010, 24:1700-1713.
7. Briggs L.J., Johnstone R.W., Elliot R.M., Xiao C.Y., Dawson M., Trapani J.A., Jans D.A. Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16. Biochem. J 2001, 353:69-77.
8. Bryan N.B., Dorfleutner A., Rojanasakul Y., Stehlik C. Activation of inflammasomes require intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain. J. Immunol. 2009, 182:3173-3182.
9. Burckstummer T., Baumann C., Bluml S., Dixit E., Durnberger G., Jahn H., Planyavsky M., Bilban M., Colinge J., Bennett K.L., Superti-Furga G. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 2009, 10:266-272.
10. Choubey D., Deka R., Ho S.M. Interferon-inducible IFI16 protein in human cancers and autoimmune diseases. Front. Biosci. 2008, 13:598-608.
11. Choubey D., Duan X., Dickerson E., Ponomareva L., Panchanathan R., Shen H., Srivastava R. Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. J. Interferon Cytokine Res. 2010, 30:371-380.
12. Choubey D., Lengyel P. Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi200 gene from the gene 200-cluster. J. Interferon Res. 1993, 13:43-52.
13. Costa S., Borgogna C., Mondini M., De Andrea M., Meroni P.L., Berti E., Gariglio M., Landolfo S. Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing. Br. J. Dermatol. 2011, 164:282-290.
14. Cristea I.M., Moorman N.J., Terhune S.S., Cuevas C.D., O'Keefe E.S., Rout M.P., Chait B.T., Shenk T. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J. Virol. 2010, 84:7803-7814.
15. Dawson M.J., Trapani J.A. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. J. Cell. Biochem. 1995, 57:39-51.
16. Dawson M.J., Trapani J.A. The interferon-inducible autoantigen, IFI 16: localization to the nucleolus and identification of a DNA-binding domain. Biochem. Biophys. Res. Commun. 1995, 214:152-162.
17. Duan X., Ponomareva L., Veeranki S., Panchanathan R., Dickerson E., Choubey D. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol. Cancer Res. 2011, 9:589-602.
18. Emmott E., Hiscox J.A. Nucleolar targeting: the hub of the matter. EMBO Rep. 2009, 10:231-238.
19. Fernandes-Alnemri T., Yu J.W., Datta P., Wu J., Alnemri E.S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009, 458:509-513.
20. Gugliesi F., Mondini M., Ravera R., Robotti A., de Andrea M., Gribaudo G., Gariglio M., Landolfo S. Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J. Leukoc. Biol. 2005, 77:820-829.
21. Guinez C., Morelle W., Michalski J.C., Lefebvre T. O-GlcNAc glycosylation: a signal for the nuclear transport of cytosolic proteins?. Int. J. Biochem. Cell Biol. 2005, 37:765-774.
22. Hornung V., Ablasser A., Charrel-Dennis M., Bauernfeind F., Horvath G., Caffrey D.R., Latz E., Fitzgerald K.A. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009, 458:514-518.
23. Johnstone R.W., Kershaw M.H., Trapani J.A. Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. Biochemistry 1998, 37:11924-11931.
24. Johnstone R.W., Trapani J.A. Transcription and growth regulatory functions of the HIN-200 family of proteins. Mol. Cell. Biol. 1999, 19:5833-5838.
25. Johnstone R.W., Wei W., Greenway A., Trapani J.A. Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene 2000, 19:6033-6042.
26. Kerur N., Veettil M.V., Sharma-Walia N., Bottero V., Sadagopan S., Otageri P., Chandran B. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 2011, 9:363-375.
27. Kimkong I., Avihingsanon Y., Hirankarn N. Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus. J. Rheumatol. 2010, 37:1544-1547.
28. Kis-Toth K., Szanto A., Thai T.H., Tsokos G.C. Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response. J. Immunol. 2011, 187:1222-1234.
29. Liao J.C., Lam R., Brazda V., Duan S., Ravichandran M., Ma J., Xiao T., Tempel W., Zuo X., Wang Y.X., Chirgadze N.Y., Arrowsmith C.H. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure 2011, 19:418-429.
30. Ludlow L.E., Johnstone R.W., Clarke C.J. The HIN-200 family: more than interferon-inducible genes?. Exp. Cell Res. 2005, 308:1-17.
31. Mihara M., Erster S., Zaika A., Petrenko O., Chittenden T., Pancoska P., Moll U.M. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 2003, 11:577-590.
32. Mondini M., Costa S., Sponza S., Gugliesi F., Gariglio M., Landolfo S. The interferon-inducible HIN-200 gene family in apoptosis and inflammation: implication for autoimmunity. Autoimmunity 2010, 43:226-231.
33. Ouchi M., Ouchi T. Role of IFI16 in DNA damage and checkpoint. Front. Biosci. 2008, 13:236-239.
34. Rubbi C.P., Milner J. Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus. Oncogene 2000, 19:85-96.
35. Shaulsky G., Goldfinger N., Ben-Ze'ev A., Rotter V. Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis. Mol. Cell. Biol. 1990, 10:6565-6577.
36. Simental J.A., Sar M., Lane M.V., French F.S., Wilson E.M. Transcriptional activation and nuclear targeting signals of the human androgen receptor. J. Biol. Chem. 1991, 266:510-518.
37. Unterholzner L., Keating S.E., Baran M., Horan K.A., Jensen S.B., Sharma S., Sirois C.M., Jin T., Latz E., Xiao T.S., Fitzgerald K.A., Paludan S.R., Bowie A.G. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 2010, 11:997-1004.
38. Veeranki S., Duan X., Panchanathan R., Liu H., Choubey D. IFI16 protein mediates the antiinflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS One 2011, 6:e27040.
39. Xin H., Curry J., Johnstone R.W., Nickoloff B.J., Choubey D. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene 2003, 22:4831-4840.
40. Yan H., Dalal K., Hon B.K., Youkharibache P., Lau D., Pio F. RPA nucleic acid-binding properties of IFI16-HIN200. Biochim. Biophys. Acta 2008, 1784:1087-1097.