Exacerbation of cerebral radiation necrosis by bevacizumab

Journal of Clinical Oncology

Volumn 29, Issue 7, 2011, Pages

  Jeyaretna, Deva Sanjeeva ^a   Curry Jr , William T ^a   Batchelor, Tracy T ^a   Stemmer Rachamimov, Anat ^a   Plotkin, Scott R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Boston; MA

Indexed keywords

BEVACIZUMAB; DEXAMETHASONE; GADOLINIUM; TEMOZOLOMIDE;

ADULT; ARTICLE; ASTROCYTOMA; BRAIN NECROSIS; CASE REPORT; CELL PROLIFERATION; DIFFUSION WEIGHTED IMAGING; DISEASE EXACERBATION; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOPATHOLOGY; HUMAN; MALE; MULTIPLE CYCLE TREATMENT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RADIATION NECROSIS; SEIZURE;

ADULT; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL; ASTROCYTOMA; BRAIN NEOPLASMS; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HUMANS; MALE; NECROSIS; RADIATION INJURIES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 79952297929     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.31.4815     Document Type: Article

References (12)

1. Wong ET, Huberman M, Lu XQ, et al: Bevacizumab reverses cerebral radiation necrosis. J Clin Oncol 26:5649-5650, 2008
2. Gonzalez J, Kumar AJ, Conrad CA, et al: Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 67:323-326, 2007 (Pubitemid 46108339)
3. Brandsma D, Stalpers L, Taal W, et al: Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453-461, 2008 (Pubitemid 351597795)
4. Kumar AJ, Leeds NE, Fuller GN, et al: Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment. Radiology 217:377-384, 2000
5. Ruben JD, Dally M, Bailey M, et al: Cerebral radiation necrosis: Incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int J Radiat Oncol Biol Phys 65:499-508, 2006
6. Giglio P, Gilbert MR: Cerebral radiation necrosis. Neurologist 9:180-188, 2003 (Pubitemid 36944725)
7. Perry A, Schmidt RE: Cancer therapy-associated CNS neuropathology: An update and review of the literature. Acta Neuropathol 111:197-212, 2006
8. Wong CS, Van der Kogel AJ: Mechanisms of radiation injury to the central nervous system: Implications for neuroprotection. Mol Interv 4:273-284, 2004
9. Nordal RA, Nagy A, Pintilie M, et al: Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: A role for vascular endothelial growth factor. Clin Cancer Res 10:3342-3353, 2004 (Pubitemid 38685439)
10. Jain RK: Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307:58-62, 2005
11. Tong RT, Boucher Y, Kozin SV, et al: Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64:3731-3736, 2004 (Pubitemid 38697278)
12. Willett CG, Boucher Y, di Tomaso E, et al: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10:145-147, 2004 (Pubitemid 38524883)